Publications of Carsten Kuenne

Wang, L.; Staps, M.; Gunther, S.; El Agha, E.; Bellusci, S.; Kuenne, C.; Du, J.; Schneider, A.; Braun, T.: Cell Type-Specific Targeting of Different Smooth Muscle Cell Populations by Intersectional Genetics. CIRCULATION 154 (6), pp. 565 - 583 (2026)

Walter, J.; Kuenne, C.; Knoppik, N.; Goymann, P.; Looso, M.: FRED enables standardized FAIR metadata generation and management for omics research. SCIENTIFIC REPORTS 16 (1), 23202 (2026)

Mansouri, S.; Hesami, G.; Ambikan, A.; Karger, A.; Klatt, S.; Neogi, U.; Kurakula, K. B.; Aliraj, B.; Miller, A.; Petrova, B. et al.; Sanda, M.; Sirait-Fischer, E.; Guenther, S.; Kuenne, C.; Ruppert, C.; Alkoudmani, I.; Gattenlohner, S.; Zukunft, S.; Fleming, I.; Haschemi, A.; Stiewe, T.; Grimminger, F.; Reck, M.; Weigert, A.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: IRG1/itaconate rewires macrophage and lung tumor metabolism through G6PD inhibition. CELL METABOLISM 38 (7), pp. 1460 - 1477 (2026)

Schultheis, H.; Detleffsen, J.; Wiegandt, R.; Bentsen, M.; Alayoubi, Y.; Valente, G.; Kessler, M. F.; Bruns, B.; Mirza, D.; Usanayo, A. et al.; Mueller, K.; Walter, J.; Goymann, P.; Hobein, M.; Kuenne, C.; Looso, M.: SC-framework: A robust and FAIR semi-interactive environment for single-cell resolution datasets. ISCIENCE 29 (7), 116631 (2026)

Raheja, M.; Guven, B.; Szymanski, W.; Gunther, S.; Kuenne, C.; Rakultsev, V.; Segarra, M.; Bozkurt, S.; Munch, C.; Kaulich, M. et al.; Graumann, J.; Fleming, I.; Siragusa, M.: A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces cell cycle arrest and senescence. CELL COMMUNICATION AND SIGNALING 24 (1), 372 (2026)

Siragusa, M.; Graumann, J.; Kuenne, C.; Gunther, S.; Jeratsch, S.; Guven, B.; Susser, S.; Talyan, S.; Bezuneh, B.; Matthess, Y. et al.; Cartura, M.; Zhou, X.; Cho, H.; Sachs, N.; Maegdefessel, L.; Muller, O. J.; Troidl, C.; Nef, H. M.; Looso, M.; Kaulich, M.; Offermanns, S.; Fleming, I.: Identification of unannotated microproteins involved in endothelial cell homeostasis, dysfunction, and vascular disease. CARDIOVASCULAR RESEARCH (2026)

Thurner, L.; Fadle, N.; Thurner, B.; Kos, I. A.; Bewarder, M.; Regitz, E.; Bette, B.; Fischer, Y.; Lesan, V.; Rixecker, T. et al.; Hoffmann, M.-C.; Preuss, K.-D.; Schormann, C.; Kaddu-Mulindwa, D.; Roemer, K.; Cetin, O.; Mang, S.; Becker, A.; Seiler, F.; Herr, C.; Lensch, C.; Lehmann, J.; Thiel-Bodenstaff, A.; Link, A.; Werner, C.; Wuchter, P.; Korper, S.; Pfuhl, T.; Lohse, S.; Rissland, J.; Thieser, K.; Pilch, J.; Papan, C.; Roth, S.; Vehreschild, J. J.; Scherer, M.; Brohl, I.; Wagner, P.; Witzenrath, M.; Thibeault, C.; Haack, I. a.; Mitrov, L.; Putz, S. M.; Reese, J.-P.; Krawczak, M.; Hamelmann, E.; Kopfnagel, V.; Fiedler, K.; Geisler, R.; Valentin, H.; Stahl, D.; Hanss, S.; Ameling, S.; Volker, U.; Hansch, S.; Dorr, M.; Blaschke, S.; Braunsteiner, J.; Dahl, E.; Pape, D.; Petersmann, A.; Stilgenbauer, S.; Bloos, F.; Schrezenmeier, H.; Langer, F.; Gabelein, G.; Friesenhahn-Ochs, B.; Pfeifer, J.; Bauer, M.; Becker, S. L.; Neumann, F.; Bohm, M.; Anton, G.; Kuenne, C.; Pullamsetti, S. S.; Looso, M.; Bals, R.; Smola, S.; Meybohm, P.; Krawczyk, M.; Lepper, P. M.; Kessel, C.: Autoantibodies to IL-1Ra and PGRN in severe COVID-19 are associated with inflammation-induced hyperphosphorylated antigen isoforms. NATURE COMMUNICATIONS 17 (1), 4768 (2026)

Leberzammer, J.; Abplanalp, W. T.; Grikscheit, K.; Solomonidis, E. G.; Glaser, S.-F.; Schuhmacher, B.; Merten, M.; Jeremijev, G.; Wilken-Schmitz, A.; Korth, L. et al.; John, D.; Gunther, S.; Kuenne, C.; Looso, M.; Valasarajan, C.; Benes, V.; Jung, F.; Niehaus, V.; Anton, G.; Stellbrink, C.; Rommele, C.; Gopel, S.; Pullamsetti, S. S.; Vehreschild, J.; Vehreschild, M.; Ciesek, S.; Leistner, D. M.; Zeiher, A. M.; Dimmeler, S.; Cremer, S.: Atherosclerosis licenses for an exceeding immune response in COVID-19 disease by interferon priming in circulating myeloid cells. CARDIOVASCULAR RESEARCH (2026)

Zhou, X.; Kuenne, C.; Gunther, S.; Wittig, I.; Guven, B.; Boutguetait, D.; Delgado Lagos, F.; Sachs, N.; Maegdefessel, L.; Muller, O. J. et al.; Munch, C.; Offermanns, S.; Fleming, I.; Siragusa, M.: Nuclear eNOS Interacts With and S-Nitrosates ADAR1 to Modulate Type I Interferon Signaling and Endothelial Function. CIRCULATION 152 (25) (2025)

Mukherjee, D.; Larcher, V.; Winter, H.; Sachs, N.; Andriani, F.; Chiesa, M.; Perrucci, G. L.; Rega, S.; Gunther, S.; Kuenne, C. et al.; Martin, J. C.; Gu, Y.; Pelisek, J.; Fischer, A.; Peruzzo, S.; Pizzo, E.; Peterson, K. L.; Dimmeler, S.; Maegdefessel, L.; Cattaneo, P.; Evans, S. M.; Guimaraes-Camboa, N.: Transcription regulation by TBX18 in smooth muscle cells is essential for normal aortic development and homeostasis. CARDIOVASCULAR RESEARCH (2025)

Georgieva, A. M.; Sreenivasan, K.; Ding, D.; Villeneuve, C.; Wickstrom, S. A.; Gunther, S.; Kuenne, C.; Gartner, U.; Guo, X.; Zhou, Y. et al.; Yuan, X.; Braun, T.: Regulation of NSL by TAF4A is critical for genome stability and quiescence of muscle stem cells. NATURE COMMUNICATIONS 16 (1), 8726 (2025)

Jan, D.; Brenton, B.; Bentsen, M.; Kuenne, C.; Looso, M.: PEAKQC: periodicity evaluation in single-cell ATAC-seq data for quality assessment. BRIEFINGS IN BIOINFORMATICS 26 (5), bbaf465 (2025)

Jafari, L.; Wiedenroth, C. B.; Kriechbaum, S. D.; Gruen, D.; Chelladurai, P.; Guenther, S.; Kuenne, C.; Spaeth, A. M.; Cherian, A. V.; Troidl, C. et al.; Wilhelm, J.; Keranov, S.; Keller, T.; Kojonazarov, B.; Schermuly, R. T.; Guth, S.; Doerr, O.; Nef, H.; Boehm, M.; Spiekerkoetter, E.; Leszek, P.; Varga, Z. V.; Ferdinandy, P.; Ghofrani, H. A.; Dorfmueller, P.; Weissmann, N.; Hamm, C. W.; Mayer, E.; Seeger, W.; Liebetrau, C.; Pullamsetti, S. S.: Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension govern right ventricle remodeling and recovery. NATURE CARDIOVASCULAR RESEARCH 4 (7) (2025)

Jin, Y.-J.; Liang, G.; Li, R.; Wang, S.; Alnouri, M. W.; Bentsen, M.; Kuenne, C.; Guenther, S.; Yan, Y.; Li, Y. et al.; Wettschureck, N.; Offermanns, S.: Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression. NATURE CARDIOVASCULAR RESEARCH 4 (2) (2025)

Zhou, L.; Pereiro, M. T.; Li, Y.; Derigs, M.; Kuenne, C.; Hielscher, T.; Huang, W.; Kraenzlin, B.; Tian, G.; Kobayashi, K. et al.; Lu, G.-H. N.; Roedl, K.; Schmidt, C.; Guenther, S.; Looso, M.; Huber, J.; Xu, Y.; Wiech, T.; Sperhake, J.-P.; Wichmann, D.; Groene, H.-J.; Worzfeld, T.: Glucocorticoids induce a maladaptive epithelial stress response to aggravate acute kidney injury. SCIENCE TRANSLATIONAL MEDICINE 16 (767), eadk5005 (2024)

Vega-Sendino, M.; Luettmann, F. F.; Olbrich, T.; Chen, Y.; Kuenne, C.; Stein, P.; Tillo, D.; Carey, G. I.; Zhong, J.; Savy, V. et al.; Radonova, L.; Lu, T.; Saykali, B.; Kim, K.-P.; Domingo, C. N.; Schueler, L.; Guenther, S.; Bentsen, M.; Bosnakovski, D.; Schoeler, H.; Kyba, M.; Maity, T. K.; Jenkins, L. M.; Looso, M.; Williams, C. J.; Kim, J.; Ruiz, S.: The homeobox transcription factor DUXBL controls exit from totipotency. NATURE GENETICS (56), pp. 697 - 709 (2024)

Torres, L. D. H.; Rezende, F.; Peschke, E.; Will, O.; Hoevener, J.-B.; Spiecker, F.; Oezorhan, U.; Lampe, J.; Stoelting, I.; Aherrahrou, Z. et al.; Kuenne, C.; Kusche-Vihrog, K.; Matschl, U.; Hille, S.; Brandes, R. P.; Schwaninger, M.; Mueller, O. J.; Raasch, W.: Incidence of microvascular dysfunction is increased in hyperlipidemic mice, reducing cerebral blood flow and impairing remote memory. FRONTIERS IN ENDOCRINOLOGY 15, 1338458 (2024)

Albu, M.; Affolter, E.; Gentile, A.; Xu, Y.; Kikhi, K.; Howard, S.; Kuenne, C.; Priya, R.; Gunawan, F.; Stainier, D. Y. R.: Distinct mechanisms regulate ventricular and atrial chamber wall formation. NATURE COMMUNICATIONS 15 (1), 8159 (2024)

Wu, F.; Li, X.; Looso, M.; Liu, H.; Ding, D.; Guenther, S.; Kuenne, C.; Liu, S.; Weissmann, N.; Boettger, T. et al.; Atzberger, A.; Kolahian, S.; Renz, H.; Offermanns, S.; Gaertner, U.; Potente, M.; Zhou, Y.; Yuan, X.; Braun, T.: Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine. NATURE GENETICS 55 (1), pp. 100 - + (2024)

Li, X.; Wu, F.; Guenther, S.; Looso, M.; Kuenne, C.; Zhang, T.; Wiesnet, M.; Klatt, S.; Zukunft, S.; Fleming, I. et al.; Poschet, G.; Wietelmann, A.; Atzberger, A.; Potente, M.; Yuan, X.; Braun, T.: Inhibition of fatty acid oxidation enables heart regeneration in adult mice. NATURE (2023)