Circadian regulation of Cardiometabolism


Circadian regulation of Cardiometabolism lab

The Dierickx lab is interested in how the circadian clock drives rhythmic processes in the heart. Circadian rhythms coordinate many aspects of behavior and physiology (e.g., fasting/feeding cycles, sleep to wake transitions and body temperature) to be in synchrony with the 24-hour rotation of the earth. In humans, disruption of these rhythms is highly associated with increased risk for cardiovascular disease development. The indispensability of clock proteins in the heart is mechanistically illustrated by our recent findings that REV-ERB loss in cardiomyocytes specifically leads to dilated cardiomyopathy and premature death in mice.

Projects in the lab are centered around an integrated approach combining next-generation sequencing techniques, whole-body physiology analysis in specialized mutant mouse lines and the use of in vitro cardiac models. We aim to develop cardiometabolic insufficiency treatment strategies and will use data from human patients to better understand how deregulation of the clock contributes to heart disease. Investigating how the circadian clock and its intricate connection to rhythmic metabolic programs can be deployed to tackle prevention, diagnosis and treatment of HF is the overarching goal.

We are always on the lookout for passionate people to join our team! Experience with animal models, (stem) cell culture and/or bioinformatic analysis of next-gen data (e.g. single nuclei RNA-seq/ATAC-seq/Cut&Run) would be a great plus.

Informal inquiries are welcome and should be sent to this email address.
 

Selected Publications:

-Dierickx P, et al. Nicotinamide riboside improves cardiac function and prolongs survival after disruption of the cardiomyocyte clock.

Frontiers in Molecular Medicine. 2022

-Dierickx P, et al. Circadian REV-ERBs repress E4bp4 to activate NAMPT-dependent NAD+ biosynthesis and sustain cardiac function.

Nature Cardiovascular Research. 2022

-Dhillon P, et al. The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation.

Cell Metabolism. 2021

-Guan D, et al. The hepatocyte clock and feeding control chronophysiology of multiple liver cell types.

Science. 2020

-Dierickx P, et al. SR9009 has REV-ERB-independent effects on cell proliferation and metabolism.

PNAS. 2019

-Hu W, et al. Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response.

Cell Stem Cell. 2019

-Dierickx P, et al. Circadian clocks: from stem cells to tissue homeostasis and regeneration.

EMBO Reports. 2017

-du Pré BC*, Dierickx P*, et al. Neonatal rat cardiomyocytes as an in vitro model for circadian rhythms in the heart. *Co-first author. Journal of Molecular and Cellular Cardiology. 2017

-Du Pré BC, et al. SCA1+ Cells from the Heart Possess a Molecular Circadian Clock and Display Circadian Oscillations in Cellular Functions.

Stem Cell Reports. 2017

-den Hamer A, et al. M. Bright bioluminescent BRET sensor proteins for measuring intracellular caspase activity. ACS Sensors. 2017

-Dierickx P, et al. Circadian networks in human embryonic stem cell-derived cardiomyocytes.

EMBO Reports. 2017

-Tiburcy M, et al. Defined Engineered Human Myocardium with Advanced Maturation for Applications in Heart Failure Modelling and Repair.

Circulation. 2017

-Dierickx P & van Laake L.W. Muscle-on-chip: An in vitro model for donor-host cardiomyocyte coupling.

Journal of Cell Biology. 2016

-Aper SJA., et al. Dual Readout BRET/FRET Sensors for Measuring Intracellular Zinc.

ACS Chemical Biology. 2016

-Haenebalcke L, et al. Efficient ROSA26-based conditional and/or inducible transgenesis using RMCE-compatible F1 hybrid mouse embryonic stem cells.

Stem Cell Reviews and Reports. 2013

-Haenebalcke L, et al. The ROSA26-iPSC mouse: a conditional, inducible, and exchangeable resource for studying cellular (De)differentiation.

Cell Reports. 2013

 

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