Scientific Publications

Maroli, G.; Scha, A.; Guenther, S.; -Gonzalez, C. G.; Rupp, S.; Schlierbach, H.; Chen, Y.; Graumann, J.; Wietelmann, A.; Kim, J. et al.; Braun, T.: Inhibition of autophagy prevents cardiac dysfunction at early stages of cardiomyopathy in Bag3-deficient hearts. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 193, pp. 53 - 66 (2024)

Castro, C. F. G.; Nardiello, C.; Hadzic, S.; Kojonazarov, B.; Kraut, S.; Gierhardt, M.; Schaeffer, J.; Bednorz , M.; Quanz, K.; Heger, J. et al.; Korfei, M.; Wilhelm, J.; Hecker, M.; Bartkuhn, M.; Arnhold , S.; Guenther, A.; Seeger, Werner (Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Max Planck Society), W.; Schulz, R.; Weissmann, N.; Sommer, N.; Pak, O.: The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung. AGING AND DISEASE (2024)

Peng, Y.; Du, J.; Li, R.; Guenther, S.; Wettschureck, N.; Offermanns, S.; Wang, Y.; Schneider, A.; Braun, T.: RhoA-mediated G₁₂-G₁₃ signaling maintains muscle stem cell quiescence and prevents stem cell loss. CELL DISCOVERY 10 (1), 76 (2024)

Gentile, A.; Albu, P. M.; Xu, Y.; Mortazavi , N.; da Silva, A.; Stainier, D. Y. R.; Gunawan, F.: Mechanical forces remodel the cardiac extracellular matrix during zebrafish development. DEVELOPMENT 151 (13), dev202310 (2024)

Jurida, L.; Werner, S.; Knapp, F.; Niemann, B.; Li, L.; Gruen, D.; Wirth, S.; Weber, A.; Beuerlein, K.; Liebetrau, C. et al.; Wiedenroth, C. B.; Guth, S.; Kojonazarov, B.; Jafari, L.; Weissmann, N.; Guenther, S.; Braun, T.; Bartkuhn, M.; Schermuly, R. T.; Dorfmueller, P.; Yin, X.; Mayr, M.; Schmitz, M. L.; Czech, L.; Schlueter, K.-D.; Schulz, R.; Rohrbach, S.; Kracht, M.: A common gene signature of the right ventricle in failing rat and human hearts. NATURE CARDIOVASCULAR RESEARCH 3 (7) (2024)

Hernandez-Olmos, V.; Heering, J.; Marinescu, B.; Schermeng, T.; Ivanov, V. V.; Moroz, Y. S.; Nevermann, S.; Mathes, M.; Ehrler, J. H. M.; Alnouri, M. W. et al.; Wolf, M.; Haydo, A. S.; Schmachtel, T.; Zaliani, A.; Ho''fner, G.; Kaiser, A.; Schubert-Zsilavecz, M.; Beck-Sickinger, A. G.; Offermanns, S.; Gribbon, P.; Rieger, M. A.; Merk, D.; Sisignano, M.; Steinhilber, D.; Proschak, E.: Development of a Potent and Selective G2A (GPR132) Agonist. JOURNAL OF MEDICINAL CHEMISTRY (2024)

Kumari, P.; Tarighi, S.; Fuchshuber, E.; Li, L.; Fernandez-Duran, I.; Wang, M.; Ayoson, J.; Castello-Garcia, J. M.; Gamez-Garcia, A.; Espinosa-Alcantud, M. et al.; Sreenivasan, K.; Guenther, S.; Olivella, M.; Savai, R.; Yue, S.; Vaquero, A.; Braun, T.; Ianni, A.: SIRT7 promotes lung cancer progression by destabilizing the tumor suppressor ARF. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (25), e2409269121 (2024)

Budczies, J.; Romanovsky, E.; Kirchner, M.; Neumann, O.; Blasi, M.; Schnorbach, J.; Shah, R.; Bozorgmehr, F.; Savai, R.; Stiewe, T. et al.; Peters, S.; Schirmacher, P.; Thomas, M.; Kazdal, D.; Christopoulos, P.; Stenzinger, A.: KRAS and TP53 co-mutation predicts benefit of immune checkpoint blockade in lung adenocarcinoma. BRITISH JOURNAL OF CANCER (2024)

Brichkina, A.; Ems, M.; Suezov, R.; Singh, R.; Lutz, V.; Picard, F. S. R.; Nist, A.; Stiewe, T.; Graumann, J.; Daude, M. et al.; Diederich, W. E.; Finkernagel, F.; Chung, H.-R.; Bartsch, D. K.; Roth, K.; Keber, C.; Denkert, C.; Huber, M.; Gress, T. M.; Lauth, M.: DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer. GUT (2024)

Zhu, Y.; Ackers-Johnson, M.; Shanmugam, M. K.; Pakkiri, L. S.; Drum, C. L.; Chen, Y.; Kim, J.; Paltzer, W. G.; Mahmoud, A. I.; Tan, W. L. W. et al.; Lee, M. C. J.; Jiang, J.; Luu, D. A. T.; Ng, S. L.; Li, P. Y. Q.; Wang, A.; Qi, R.; Ong, G. J. X.; Ng, T. Y.; Haigh, J. J.; Tiang, Z.; Richards, A. M.; Foo, R. S. Y.: Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation. CIRCULATION 149 (23), pp. 1833 - 1851 (2024)

Gauvrit, S.; Zhao, S.; Rothbauer, U.; Stainier, D. Y. R.: A β-catenin chromobody-based probe highlights endothelial maturation during vascular morphogenesis in vivo. DEVELOPMENT 151 (11), dev202122 (2024)

Nawn , D.; Hassan, S. S.; Redwan, E. M.; Bhattacharya, T.; Basu, P.; Lundstrom, K.; Uversky, V. N.: Unveiling the genetic tapestry: Rare disease genomics of spinal muscular atrophy and phenylketonuria proteins. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 269, 131960 (2024)

Schlueter, B. C.; Quanz, K.; Baldauf, J.; Petrovic, A.; Ruppert, C.; Guenther, A.; Gall, H.; Tello, K.; Grimminger, F.; Ghofrani, H. -. et al.; Weissmann, N.; Seeger, W.; Schermuly, R. T.; Weiss, A.: The diverging roles of insulin-like growth factor binding proteins in pulmonary arterial hypertension. VASCULAR PHARMACOLOGY 155, 107379 (2024)

Brunnberg, J.; Barends, M.; Fruehschulz, S.; Winter, C.; Battin, C.; de Wet, B.; Cole, D. K.; Steinberger, P.; Tampe, R.: Dual role of the peptide- loading complex as proofreader and limiter of MHC- I presentation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (22), e2321600121 (2024)

Ribeiro da Silva, A.; Gunawan, F.; Boezio, G. L. M.; Faure , E.; Theron , A.; Avierinos , J.-F.; Lim, S.; Shivam, G. J.; Ramadass, R.; Guenther, S. et al.; Looso, M.; Zaffran, S.; Juan, T.; Stainier, D. Y. R.: egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis. SCIENCE ADVANCES 10 (20), eadl0633 (2024)

Hachenberger, M.; Braun, T.; Gerner, S. T.; Suenner, L.; Schaenzer, A.; Juenemann, M.; Mueller, C.; Wietelmann, A.; Stolz, E.; Schoenburg, M. et al.; Tschernatsch, M.; Gerriets, T.; Huttner, H. B.; Yeniguen, M.: Aluminium Chloride instead of Ferric chloride for inducing superior sagittal sinus thrombosis to reduce ferromagnetic artifacts on MRI-imaging in experimental models. SCIENTIFIC REPORTS 14 (1), 10998 (2024)

Tamiato, A.; Tombor, L. S.; Fischer, A.; Muhly-Reinholz, M.; Vanicek, L. R.; Togru, B. N.; Neitz, J.; Glaser, S. F.; Merten, M.; Morales, D. R. et al.; Kwon, J.; Klatt, S.; Schumacher, B.; Guenther, S.; Abplanalp, W. T.; John, D.; Fleming, I.; Wettschureck, N.; Dimmeler, S.; Luxaen, G.: Age-Dependent RGS5 Loss in Pericytes Induces Cardiac Dysfunction and Fibrosis. CIRCULATION RESEARCH 134 (10), pp. 1240 - 1255 (2024)

Wang, T.; Shao, J.; Shamit, K.; Alnouri, M. W.; Carvalho, J.; Guenther, S.; Krasel , C.; Murphy, K. T.; Buenemann, M.; Offermanns, S. et al.; Wettschureck, N.: Orphan GPCR GPRC5C Facilitates Angiotensin II-Induced Smooth Muscle Contraction. CIRCULATION RESEARCH 134 (10), pp. 1259 - 1275 (2024)

Cardeira-da-Silva, J.; Wang, Q.; Sagvekar, P.; Mintcheva, J.; Latting, S.; Guenther, S.; Ramadass, R.; Yekelchyk, M.; Preussner, J.; Looso, M. et al.; Junker, J. P.; Stainier, D. Y. R.: Antigen presentation plays positive roles in the regenerative response to cardiac injury in zebrafish. NATURE COMMUNICATIONS 15 (1), 3637 (2024)

Martin, D.; Roedel, F.; Hehlgans, S.; Looso, M.; Ziegler, P. K.; Fleischmann, M.; Diefenhardt, M.; Fries, L.; Kalinauskaite, G.; Tinhofer, I. et al.; Zips, D.; Gani, C.; Roedel, C.; Fokas, E.: Inflammatory pathways confer resistance to chemoradiotherapy in anal squamous cell carcinoma. NPJ PRECISION ONCOLOGY 8 (1), 93 (2024)