Scientific Publications

Wittig, J.; Xu, R.; Lagos, F. D.; Drekolia, M.-K.; Zhang, B.; Theodorou, I.; Chen, Y.; Du, Y.; Gupta, L.; Hanyu, C. et al.; Yuanyuan, L.; Bo, C.; Gunther, S.; Wittig, I.; Ola, R.; Hu, J.; Bibli, S.-I.: Persulfidation alters gene regulatory programs and promotes endothelial specification. REDOX BIOLOGY 89, 103926 (2026)

Leerberg, D. M.; Avillion, G. B.; Priya, R.; Stainier, D. Y. R.; Yelon, D.: Regionalized regulation of actomyosin organization influences cardiomyocyte cell shape changes during chamber curvature formation. NATURE COMMUNICATIONS 17 (1), 3768 (2026)

Bhingardeve, S.; Sagvekar, P.; Desai, S.; Mangoli, V.; Jagtap, R.; Mukherjee, S.: RNA m6A modification and its regulatory factors are altered in granulosa cells from women with PMOS. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2026)

Malacarne, P. F.; Lopez, M.; Chatterjee, S.; Herrle, N.; Weiss, L.; Gunther, S.; Osborne, T.; Glaubitz, C.; Schmid, T.; Kurrle, N. et al.; Schnutgen, F.; Lutjohann, D.; Brandes, R. P.; Rezende, F.: Endothelial cytochrome P450-derived cholesterol limits angiogenesis. REDOX BIOLOGY 95, 104289 (2026)

Cartura, M.; Aliraj, B.; Szymanski, W.; Park, C.; Ferrario, G.; Rezende, F.; Guven, B.; Bleckwehl, T.; Sachs, N.; Magdefessel, L. et al.; Dimmeler, S.; Muller, O. J.; Jo, H.; Offermanns, S.; Hayat, S.; Brandes, R. P.; Munch, C.; Graumann, J.; Weigert, A.; Fleming, I.; Siragusa, M.: Immunomodulatory endothelial cells contribute to T-cell recruitment and activation via antigen presentation on MHC II. CARDIOVASCULAR RESEARCH 122 (12), pp. 1672 - 1687 (2026)

Ilyas, I.; Evans, P. C.; Berk, B. C.; Offermanns, S.; Xu, S.: Endothelial to mesenchymal transition (EndMT) in atherosclerosis: mechanisms, models, and therapies. CARDIOVASCULAR RESEARCH 122 (12), pp. 1555 - 1572 (2026)

Wang, L.; Staps, M.; Gunther, S.; El Agha, E.; Bellusci, S.; Kuenne, C.; Du, J.; Schneider, A.; Braun, T.: Cell Type-Specific Targeting of Different Smooth Muscle Cell Populations by Intersectional Genetics. CIRCULATION 154 (6), pp. 565 - 583 (2026)

Miserocchi, M.; De Meyer, P.; Lattuca, R.; Montanari, A.; Ferrero, G.; Boezio, G.; Stainier, D. Y. R.; Wittamer, V.: Tgf-β receptor signaling cell-intrinsically controls conserved microglia homeostatic maturation during zebrafish development. CELL REPORTS 45 (8), 117795 (2026)

Kwon, J.; Persechino, M.; Shao, J.; Shamsara, J.; Spitznagel, B.; Salwig, I.; Sanda, M.; Offermanns, S.; Kolb, P.; Wettschureck, N.: Small molecule inhibitor of orphan GPCR dimerization improves host defense and blood pressure control in mice. JOURNAL OF CLINICAL INVESTIGATION 136 (15), e203162 (2026)

Hofmann, T.; Hettrich, S.; Idrissou, B. M. G.; Waechter, C.; Weiss, M.; Hachim, S.; Kreher, S.; Staps, M.; Canes Esteve, L.; Pankuweit, S. et al.; Milting, H.; Looso, M.; Marty, I.; Engelhardt, S.; Braun, T.; Boettger, T.: Trdn-as directs m6A-dependent transcriptional termination for accurate triadin isoform switching, preventing aberrant dyads and cardiomyopathy cardiomyopathy. NATURE COMMUNICATIONS 17 (1), 7269 (2026)

Walter, J.; Kuenne, C.; Knoppik, N.; Goymann, P.; Looso, M.: FRED enables standardized FAIR metadata generation and management for omics research. SCIENTIFIC REPORTS 16 (1), 23202 (2026)

Panel, N.; Vo, D. D.; Hubner, H.; Deluigi, M.; Pach, S.; Belair, F.; Weikert, D.; Klenk, C.; Hilge, M.; Shiva, N. et al.; Brochu, I.; Longpre, J.-M.; Ballgren, F.; Saleh, A.; Hu, H.; Kapla, J.; Kampen, S.; Cabeza de Vaca, I.; Kihlberg, J.; Wettschureck, N.; Sarret, P.; Pluckthun, A.; Gmeiner, P.; Carlsson, J.: Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity. NATURE COMMUNICATIONS 17 (1), 6970 (2026)

Elbassioni, A. A. M.; Raheem, A. A.; Song, J.; Johnston, A. S.; Trivett, C.; Lin, H.; Zhang, H.; Bradley, A.; Higgins, E.; Thomson, C. R. et al.; Mooney, L.; Koay, Y. C.; O'Toole, D.; Herzyk, P.; Nixon, C.; Blyth, K.; Hughes, M.; Al-Attar, N.; O'Sullivan, J. F.; Lang, N. N.; Berry, C.; Braun, T.; Schiattarella, G. G.; Giacca, M.; McBride, M. W.; Nicklin, S. A.; Cameron, E. R.; Loughrey, C. M.; MacDonald, E. A.: Targeting RUNX1 protects against diastolic dysfunction in a two-hit mouse model of heart failure with preserved ejection fraction. CARDIOVASCULAR RESEARCH 122 (10), pp. 1318 - 1328 (2026)

Mansouri, S.; Hesami, G.; Ambikan, A.; Karger, A.; Klatt, S.; Neogi, U.; Kurakula, K. B.; Aliraj, B.; Miller, A.; Petrova, B. et al.; Sanda, M.; Sirait-Fischer, E.; Guenther, S.; Kuenne, C.; Ruppert, C.; Alkoudmani, I.; Gattenlohner, S.; Zukunft, S.; Fleming, I.; Haschemi, A.; Stiewe, T.; Grimminger, F.; Reck, M.; Weigert, A.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: IRG1/itaconate rewires macrophage and lung tumor metabolism through G6PD inhibition. CELL METABOLISM 38 (7), pp. 1460 - 1477 (2026)

Zhang, Y.; Sun, Y.; Xu, G.; Wu, Y.; Shi, Z.; Chang, Z.; Liu, J.; Pang, K.; Liu, S.; Wang, H. et al.; Rong, W.; Shao, Z.; Liu, X.; He, Y.; Yan, Y.; Zhou, B.; Yuan, Z.; Zhang, X.-F.; Offermanns, S.; Wang, S.: Zonated mechanosensing by PIEZO1 controls liver regeneration. SCIENCE 393 (6806), eaef0825 (2026)

Lam, F.; Warwick, T.; Oo, J. A.; Kruger, A. Y.; Kreis, N.-N.; Diagel, A.; Ponce, J. I.; Tirunagari, P.; Bayer, M. E.; Nonn, O. et al.; Dechend, R.; Walther, T.; Boon, R. A.; Baker, A. H.; Gunther, S.; Wittig, I.; Chen, Z.; Muller-McNicoll, M.; Louwen, F.; Brandes, R. P.; Leisegang, M. S.: LINC00607 facilitates endothelial VEGF-A receptor FLT1 splicing. MOLECULAR THERAPY 34 (7), pp. 4323 - 4338 (2026)

Shiva, N.; Kawase, H.; Einsiedel, J.; Kwon, J.; Kumar, S.; Shao, J.; Du, Z.; Kubin, N.; Shimari, M.; Gunther, S. et al.; Li, T.; Dierickx, P.; Sossalla, S.; Offermanns, S.; Gmeiner, P.; Wettschureck, N.: Neurotensin receptor 2 agonism attenuates adverse cardiac remodeling in preclinical models. SCIENCE TRANSLATIONAL MEDICINE 18 (856), eaea9877 (2026)

Schultheis, H.; Detleffsen, J.; Wiegandt, R.; Bentsen, M.; Alayoubi, Y.; Valente, G.; Kessler, M. F.; Bruns, B.; Mirza, D.; Usanayo, A. et al.; Mueller, K.; Walter, J.; Goymann, P.; Hobein, M.; Kuenne, C.; Looso, M.: SC-framework: A robust and FAIR semi-interactive environment for single-cell resolution datasets. ISCIENCE 29 (7), 116631 (2026)

Hernandez-Olmos, V.; Heering, J.; Lillich, F. F.; Marinescu, B.; Nevermann, S.; Ehrler, J. H. M.; Radchenko, D. S.; Moroz, Y. S.; Kaiser, A.; Kramer, A. et al.; Knapp, S.; Schubert-Zsilavecz, M.; Alnouri, M. W.; Offermanns, S.; Steinhilber, D.; Sisignano, M.; Proschak, E.: First Structure-Activity-Relationship Study of Potent G2A Antagonists. JOURNAL OF MEDICINAL CHEMISTRY 69 (12), pp. 14309 - 14332 (2026)

Raheja, M.; Guven, B.; Szymanski, W.; Gunther, S.; Kuenne, C.; Rakultsev, V.; Segarra, M.; Bozkurt, S.; Munch, C.; Kaulich, M. et al.; Graumann, J.; Fleming, I.; Siragusa, M.: A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces cell cycle arrest and senescence. CELL COMMUNICATION AND SIGNALING 24 (1), 372 (2026)