Scientific Publications

Better, J.; Estiri, M.; Wetstein, M.; Pervizaj-Oruqaj, L.; Malainou, C.; Ogungbemi-Alt, V.; Ferrero, M. R.; Langelage, M.; Kuznetsova, I.; Vazquez-Armendariz, A. I. et al.; Kimmig, L.; Pak, O.; Mansouri, S.; Savai, R.; Wilhelm, J.; Alexopoulos, I.; Sommer, N.; Herold, S.; Matt, U.: Cell type-specific efferocytosis determines functional plasticity of alveolar macrophages. SCIENCE IMMUNOLOGY 10 (107), eadl3852 (2025)

Chen, X.; Shao, J.; Brandenburger, I.; Qian, W.; Hahnefeld, L.; Bonnavion, R.; Cho, H.; Wang, S.; Hidalgo, J.; Wettschureck, N. et al.; Geisslinger, G.; Gurke, R.; Wang, Z.; Offermanns, S.: FFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes. NATURE COMMUNICATIONS 16 (1), 3422 (2025)

Panza, P.; Kim, H.-T.; Lautenschlaeger, T.; Piesker, J.; Guenther, S.; Alayoubi, Y.; Cleaver, O.; Looso, M.; Stainier, D. Y. R.: The lung microvasculature promotes alveolar type 2 cell differentiation via secreted SPARCL1. STEM CELL REPORTS 20 (4), 102451 (2025)

Sun, L.; Leng, R.; Liu, M.; Su, M.; He, Q.; Zhang, Z.; Liu, Z.; Wang, Z.; Jiang, H.; Wang, L. et al.; Guo, S.; Xu, Y.; Huo, Y.; Miller, C. L.; Banach, M.; Huang, Y.; Evans, P. C.; Pelisek, J.; Camici, G. G.; Berk, B. C.; Offermanns, S.; Ge, J.; Xu, S.; Weng, J.: Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake. JOURNAL OF CLINICAL INVESTIGATION 135 (7), e181928 (2025)

Xu, S.; Liu, Z.; Tian, T.; Zhao, W.; Wang, Z.; Liu, M.; Xu, M.; Zhang, F.; Zhang, Z.; Chen, M. et al.; Yin, Y.; Su, M.; Fang, W.; Pan, W.; Liu, S.; Li, M.-d.; Little, P. J.; Kamato, D.; Zhang, S.; Wang, D.; Offermanns, S.; Speakman, J. R.; Weng, J.: The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21. SCIENCE ADVANCES 11 (13), eadt3142 (2025)

Ianni, A.; Vaquero, A.; Braun, T.: Fibroblastic niches in action: CCL19⁺ reticular cells drive anti-tumor immunity in lung cancer. SIGNAL TRANSDUCTION AND TARGETED THERAPY 10 (1), 96 (2025)

Manickam, N.; Sultan, I.; Panthel, J.; Kujundzic, H.; Fischer, A.; Schmitz, K.; Jurado, M. R.; Morales, D. R.; John, D.; Glaser, S.-F. et al.; Stilz, K. A.; Malacarne, P. F.; Brandes, R. P.; Braun, T.; Lerchenmueller, C.; Betge, F.; Abplanalp, W. T.; Alitalo, K.; Dimmeler, S.; Wagner, J. U. G.: Beneficial effects of vascular endothelial growth factor B gene transfer in the aged heart. CARDIOVASCULAR RESEARCH (2025)

Bhingardeve, S.; Sagvekar, P.; Desai, S.; Mangoli, V.; Jagtap, R.; Mukherjee, S.: The regulatory interplay between miRNA and DNA methylation orchestrates vital ovarian functions and associated traits in PCOS. GENE 940, 149165 (2025)

Falcucci, L.; Dooley, C. M.; Adamoski, D.; Juan, T.; Martinez, J.; Georgieva, A. M.; Mamchaoui, K.; Cirzi, C.; Stainier, D. Y. R.: Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy. NATURE (639(8054)), pp. 493 - 502 (2025)

Nawn, D.; Hassan, S. S.; Hromic-Jahjefendic, A.; Bhattacharya, T.; Basu, P.; Redwan, E. M.; Barh, D.; Andrade, B. S.; Aljabali, A. A.; Serrano-Aroca, A. et al.; Lundstrom, K.; Tambuwala, M. M.; Uversky, V. N.: Molecular genomic insights into melanoma associated proteins PRAME and BAP1. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2025)

Mikaeloff, F.; Gelpi, M.; Escos, A.; Wang, T.; Gupta, S.; Olofsson, A.; Akusjarvi, S. S.; Schuster, S.; Naval, P.; Sood, V. et al.; Nikouyan, N.; Knudsen, A. D.; Vestad, B.; Hogh, J.; Hov, J. R.; Benfield, T.; Troseid, M.; Pawar, V.; Rucevic, M.; Benfeitas, R.; Vegvari, A.; O'Mahony, L.; Savai, R.; Bjorkstrom, N. K.; Lourda, M.; de Magalhaes, J. P.; Weiss, S.; Mardinoglu, A.; Varshney, M. K.; Karlsson, A. C.; Syed, Y. A.; Nielsen, S. D.; Neogi, U.: Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo. ADVANCED SCIENCE (2025)

Khadim, A.; Kiliaris, G.; Vazquez-Armendariz, A. I.; Procida-Kowalski, T.; Glaser, D.; Bartkuhn, M.; Malik, T.; Chu, X.; Moiseenko, A.; Kuznetsova, I. et al.; Ahmadvand, N.; Lingampally, A.; Hadzic, S.; Alexopoulos, I.; Chen, Y.; Gueunther, A.; Behr, J.; Neumann, J.; Schiller, H. B.; Li, X.; Weissmann, N.; Braun, T.; Seeger, W.; Wygrecka, M.; Morty, R. E.; Herold, S.; El Agha, E.: Myofibroblasts emerge during alveolar regeneration following influenza-virus-induced lung injury. CELL REPORTS 44 (2), 115248 (2025)

Gupta, S.; Bajwa, G. K.; El-Sammak, H.; Mattonet, K.; Guenther, S.; Looso, M.; Stainier, D. Y. R.; Marin-Juez, R.: The transmembrane glycoprotein Gpnmb is required for the immune and fibrotic responses during zebrafish heart regeneration. DEVELOPMENTAL BIOLOGY 521, pp. 153 - 162 (2025)

Juan, T.; Molina, T.; Xie, L.; Papadopoulou, S.; Cardoso, B.; Jha, S. G.; Stainier, D. Y. R.: A recombinase-activated ribozyme to knock down endogenous gene expression in zebrafish. PLOS GENETICS 21 (2), e1011594 (2025)

Kwon, J.; Haruya, K.; Mattonet, K.; Guenther, S.; Hahnefeld, L.; Shamsara, J.; Heering, J.; Kurz, M.; Kirchhofer, S.; Krasel, C. et al.; Ulrich, M.; Persechino, M.; Murthy, S.; Orlandi, C.; Sadik, C. D.; Geisslinger, G.; Buenemann, M.; Kolb, P.; Offermanns, S.; Wettschureck, N.: Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling. NATURE COMMUNICATIONS 16 (1), 1448 (2025)

Lingampally, A.; Truchi, M.; Mauduit, O.; Delcroix, V.; Vasquez-Pacheco, E.; Gautier-Isola, M.; Chu, X.; Khadim, A.; Chao, C.-M.; Zabihi, M. et al.; Taghizadeh, S.; Rivetti, S.; Marega, M.; Moiseenko, A.; Hadzic, S.; Vazquez-Armendariz, A. I.; Herold, S.; Guenther, S.; Millar-Buechner, P.; Koepke, J.; Samakovlis, C.; Wilhelm, J.; Bartkuhn, M.; Braun, T.; Weissmann, N.; Zhang, J.; Wygrecka, M.; Makarenkova, H. P.; Guenther, A.; Seeger, W.; Chen, C.; El Agha, E.; Mari, B.; Bellusci, S.: Evidence for a lipofibroblast-to-Cthrc1+ myofibroblast reversible switch during the development and resolution of lung fibrosis in young mice. EUROPEAN RESPIRATORY JOURNAL 65 (2), 2300482 (2025)

Jin, Y.-J.; Liang, G.; Li, R.; Wang, S.; Alnouri, M. W.; Bentsen, M.; Kuenne, C.; Guenther, S.; Yan, Y.; Li, Y. et al.; Wettschureck, N.; Offermanns, S.: Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression. NATURE CARDIOVASCULAR RESEARCH 4 (2) (2025)

Su, M.; Zhao, W.; Jiang, H.; Zhao, Y.; Liao, Z.; Liu, Z.; Xu, M.; Jiang, S.; Wu, L.; Yang, Y. et al.; Wang, Z.; Zeng, Z.; Fang, Y.; Tang, C.; Miller, C. L.; Evans, P. C.; Wang, L.; Banach, M.; Jo, H.; Berk, B. C.; Offermanns, S.; Huang, Y.; Ge, J.; Xu, S.; Weng, J.: Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis. NATURE CARDIOVASCULAR RESEARCH 4 (2) (2025)

Eibach, Y.; Kreher, S.; Poetsch, M. S.; Kho, A. L.; Gaertner, U.; Clemen, C. S.; Schroeder, R.; Guo, K.; Milting, H.; Meder, B. et al.; Potente, M.; Richter, M.; Schneider, A.; Meiners, S.; Gaute, M.; Braun, T.: The deubiquitinase USP5 prevents accumulation of protein aggregates in cardiomyocytes. SCIENCE ADVANCES 11 (4), eado3852 (2025)

Hernandez-Olmos, V.; Heering, J.; Ildefeld, N.; Ehrler, J. H. M.; Kaps, A.; Rajkumar, R.; Marinescu, B.; Kaiser, A.; Macinkovic, I.; Elewa, M. A. F. et al.; Alnouri, M. W.; Elson, L.; Schubert-Zsilavecz, M.; Kallenborn-Gerhardt, W.; Schmidtko, A.; Mueller, S.; Offermanns, S.; Steinhilber, D.; Weigert, A.; Proschak, E.: Identification of a Chemical Probe for BLT2 Activation by Scaffold Hopping. JOURNAL OF MEDICINAL CHEMISTRY 68 (2), pp. 1195 - 1221 (2025)