Scientific Publications

Wittig, J.; Xu, R.; Lagos, F. D.; Drekolia, M.-K.; Zhang, B.; Theodorou, I.; Chen, Y.; Du, Y.; Gupta, L.; Hanyu, C. et al.; Yuanyuan, L.; Bo, C.; Gunther, S.; Wittig, I.; Ola, R.; Hu, J.; Bibli, S.-I.: Persulfidation alters gene regulatory programs and promotes endothelial specification. REDOX BIOLOGY 89, 103926 (2026)

Leerberg, D. M.; Avillion, G. B.; Priya, R.; Stainier, D. Y. R.; Yelon, D.: Regionalized regulation of actomyosin organization influences cardiomyocyte cell shape changes during chamber curvature formation. NATURE COMMUNICATIONS 17 (1), 3768 (2026)

Hernandez-Olmos, V.; Heering, J.; Lillich, F. F.; Marinescu, B.; Nevermann, S.; Ehrler, J. H. M.; Radchenko, D. S.; Moroz, Y. S.; Kaiser, A.; Kramer, A. et al.; Knapp, S.; Schubert-Zsilavecz, M.; Alnouri, M. W.; Offermanns, S.; Steinhilber, D.; Sisignano, M.; Proschak, E.: First Structure-Activity-Relationship Study of Potent G2A Antagonists. JOURNAL OF MEDICINAL CHEMISTRY 69 (12), pp. 14309 - 14332 (2026)

Morales-Cano, D.; Medrano-Garcia, S.; Barreira, B.; Hernandez-Garcia, A.; Kumar, R.; Graham, B. B.; Savai, R.; Savai Pullamsetti, S.; Perez-Vizcaino, F.; Butrous, G. et al.; Cogolludo, A.; Fernandez-Malave, E.: Pulmonary Immune Cell Landscape Altered by Exposure to HIV, Schistosoma and Their Combination. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 27 (12), 5426 (2026)

Fennell, E.; Law, S. C.; Dowell, A. C.; Pugh, M. R.; Enright, C. M.; Ross, A. M.; Hennessy, A. S.; Leahy, C. I.; Nikulina, N.; Richter, A. G. et al.; Mundo, L.; Leoncini, L.; Lazzi, S.; Siciliano, M. C.; Dojcinov, S. D.; Quintanilla-Martinez, L.; Young, K. H.; Gandhi, M. K.; Taylor, G. S.; Murray, P. G.: Loss of systemic anti-viral immunity and LMP1-driven suppressive myeloid tumour niches converge to shape the immunobiology of Epstein-Barr virus-positive diffuse large B-cell lymphoma virus-positive diffuse large B-cell lymphoma. LEUKEMIA (2026)

Candlish, M.; Hofmann, J.; Brosamle, D.; Haessler, A.; DeMeglio, M.; Skodras, A.; Tushev, G.; De Biasi, E. S.; Gunther, S.; Wiegandt, R. et al.; Theis, H.; De Domenico, E.; Hermann, N. S.; Breunig, P.; Sauerland, C.; Nilsson, K. P. R.; Beyer, M. D.; Looso, M.; Windbergs, M.; Roeber, S.; Herms, J.; Neher, J. J.; Chiocchetti, A. G.; Hefendehl, J. K.: Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology. JOURNAL OF NEUROINFLAMMATION 23 (1), 213 (2026)

Liang, Z.; Long, X.; Xiong, Z.; Wong, P. P.-C.; Huang, S.; Chen, S.; Zhang, Y.; Zhang, L.; Leung, C.; Cao, J. et al.; Wu, H.; Yue, H.; Zhao, Z.; Tu, Y.; Yin, B.; Yang, W.; Wang, J.; Chen, S.; Zhang, X.; Tsang, Y. W.; Zhong, C.; Liu, X.; Ding, L.; Lu, J.; Si-Tou, W. W.-Y.; Liu, Y.; Wang, Y.; Lin, Y.; Liang, J.; Ren, W.; Vong, J. S.-L.; Tong, M.; Tian, X.; Hui, H. X.; Zhou, J.; Ngai, S.; Ni, S.; To, K.-F.; Braun, T.; Sung, J. J.-Y.; Chan, S. L.; Cheng, A. S.-L.: Tumor cells metabolically resist immune-checkpoint therapy by macrophage efferocytosis-mediated fatty acid recycling. CANCER CELL 44 (6), pp. 1235 - 1254 (2026)

Spyropoulos, D.; Kleindienst, L.; Ehrich, P.; Ziemens, D.; Natsagdorj, R.; Noll, N.; Hansen, C. E.; Gutt, A.-S.; Menyhart, A.; Sedlacik, J. et al.; Ludewig, P.; Lembrich, B.; Ozorhan, U.; Kostenis, E.; Fiehler, J.; Huttmann, G.; Longden, T. A.; Nogueiras, R.; Prevot, V.; Muller-Fielitz, H.; Offermanns, S.; Wettschureck, N.; Farkas, E.; Schwaninger, M.; Wenzel, J.: Brain endothelial Gα q/11 signalling in cerebrovascular function and cognition of aged mice. EBIOMEDICINE 128, 106283 (2026)

Yeganeh, M.; Najar-Asl, M.; Karamzadeh, R.; Nemati, S.; Yakhkeshi, S.; Akhlaghpour, A.; Guenther, S.; Naderi, S.; Shahbazi, E.; Mollamohammadi, S. et al.; Simorgh, S.; Hassani, S.-N.; Shojaei, A.; Mirnajafizadeh, J.; Abolghasemi Dehaqani, M.-R.; Ahmadabadi, M. N.; Huang, R.; Shahpasand, K.; Hisanaga, S.-I.; Braun, T.; Baharvand, H.: Human pluripotent stem cell-derived neuroepithelial cells develop into an organizer for optic tectum formation in the chicken diencephalon. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 14, 1812038 (2026)

Siragusa, M.; Graumann, J.; Kuenne, C.; Gunther, S.; Jeratsch, S.; Guven, B.; Susser, S.; Talyan, S.; Bezuneh, B.; Matthess, Y. et al.; Cartura, M.; Zhou, X.; Cho, H.; Sachs, N.; Maegdefessel, L.; Muller, O. J.; Troidl, C.; Nef, H. M.; Looso, M.; Kaulich, M.; Offermanns, S.; Fleming, I.: Identification of unannotated microproteins involved in endothelial cell homeostasis, dysfunction, and vascular disease. CARDIOVASCULAR RESEARCH (2026)

Fuschi, G.; St Germain, J.; Bebensee, D.; Moawad, C.; Aladysheva, A.; Mohamed, A.; Brooks, B. R.; Savai, R.; Elwakeel, E.; Amin, M.: Machine Learning-Driven Drug Repurposing for KRAS G12C and KRAS G12D Inhibition. ACS OMEGA (2026)

Thurner, L.; Fadle, N.; Thurner, B.; Kos, I. A.; Bewarder, M.; Regitz, E.; Bette, B.; Fischer, Y.; Lesan, V.; Rixecker, T. et al.; Hoffmann, M.-C.; Preuss, K.-D.; Schormann, C.; Kaddu-Mulindwa, D.; Roemer, K.; Cetin, O.; Mang, S.; Becker, A.; Seiler, F.; Herr, C.; Lensch, C.; Lehmann, J.; Thiel-Bodenstaff, A.; Link, A.; Werner, C.; Wuchter, P.; Korper, S.; Pfuhl, T.; Lohse, S.; Rissland, J.; Thieser, K.; Pilch, J.; Papan, C.; Roth, S.; Vehreschild, J. J.; Scherer, M.; Brohl, I.; Wagner, P.; Witzenrath, M.; Thibeault, C.; Haack, I. a.; Mitrov, L.; Putz, S. M.; Reese, J.-P.; Krawczak, M.; Hamelmann, E.; Kopfnagel, V.; Fiedler, K.; Geisler, R.; Valentin, H.; Stahl, D.; Hanss, S.; Ameling, S.; Volker, U.; Hansch, S.; Dorr, M.; Blaschke, S.; Braunsteiner, J.; Dahl, E.; Pape, D.; Petersmann, A.; Stilgenbauer, S.; Bloos, F.; Schrezenmeier, H.; Langer, F.; Gabelein, G.; Friesenhahn-Ochs, B.; Pfeifer, J.; Bauer, M.; Becker, S. L.; Neumann, F.; Bohm, M.; Anton, G.; Kuenne, C.; Pullamsetti, S. S.; Looso, M.; Bals, R.; Smola, S.; Meybohm, P.; Krawczyk, M.; Lepper, P. M.; Kessel, C.: Autoantibodies to IL-1Ra and PGRN in severe COVID-19 are associated with inflammation-induced hyperphosphorylated antigen isoforms. NATURE COMMUNICATIONS 17 (1), 4768 (2026)

Kawase, H.; Liu, S.; Kurz, S.; Bengelsdorff, V.; Bonnavion, R.; Jin, Y.-J.; Roquid, K. A.; Cho, H.; Liang, G.; Banicevic, M. et al.; Shiva, N.; Yunes-Leites, P. S.; Gunther, S.; Tombor, L.; Dimmeler, S.; Looso, M.; Mattonet, K.; Wettschureck, N.; Muller, U. C.; Offermanns, S.: Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis. SCIENCE ADVANCES 12 (21), eaeh0301 (2026)

Wang, J.; Li, J.; Chin, A. W. H.; Luo, B.; Wei, J.; Qiu, J.; Ren, J.; Xia, Y.; Braun, T.; Poon, L. L. M. et al.; Feng, B.: Redirection of SARS-CoV-2 to phagocytes by intranasal sACE2-Fc as a universal decoy confers complete prophylactic protection. ELIFE 14, RP108883 (2026)

Dizdarevic, S.; Timofeev, O.; Kazdal, D.; Pullamsetti, S. S.; Sotillo, R.; Loges, S.; Kobold, S.; Stenzinger, A.; Stiewe, T.; Savai, R.: Tumor microenvironment evolution in lung cancer: Spatio-temporal dynamics and clinical implications. SEMINARS IN CANCER BIOLOGY 123, pp. 1 - 26 (2026)

Merkt, W.; Rodon, L.; Deicher, F. S.; Freitag, M.; Claus, M.; Lister, R.; Han, H.; Zhou, Y.; Horne, A.; Stutz, A. et al.; Li, Y.-N.; Kreuter, M.; Kahn, N.; Schneider, M. A.; Egea-Zorrilla, A.; Blasco-Iturri, Z.; Nikulina, N.; Turkowski, K.; Ruppert, C.; Guenther, A.; Rizzo, R.; Rizzo, S.; Ferraresi, M.; Hubschmann, D.; Haas, S.; Blank, N.; Watzl, C.; Tykocinski, L.-O.; Lorenz, H.-M.; Savai, R.; Pardo-Saganta, A.; Lagares, D.: Natural killer cell immunotherapy reverses lung fibrosis by eliminating senescent fibroblasts. SCIENCE TRANSLATIONAL MEDICINE 18 (849), eadq5442 (2026)

Sauda, M. R.; Rodrigues, A. B.; de Oliveira Lyra, M. L.; Grotto, R. M. T.; Gu, L.; de Campos Melo, T.; Valente, G. T.: Comparison between a conventional tool and deep learning models for RNA velocity analysis of scRNA-Seq data. MOLECULAR GENETICS AND GENOMICS 301 (1), 110 (2026)

Pullamsetti, S. S.; Vanderpool, R. R.; de Man, F.; de Jesus Perez, V. A.; Hemnes, A. R.; Mukherjee, M.; Mercer-Rosa, L.; Spiekerkoetter, E.; Tello, K.; Bonnet, S.: Advanced Molecular, Metabolic, and Imaging Approaches to Characterizing Right Ventricular Failure: A Scientific Statement From the American Heart Association. CIRCULATION 153 (19), pp. e1304 - e1322 (2026)

Kubin, N.; Gajawada, P.; Kortl, T.; Schneider, A.; Han, L.; Zelarayan, L. C.; Braun, T.; Sossalla, S.; Choi, Y.-H.; Richter, M.: Coordinated Developmental Remodeling of IGF/FGF-MAPK Signaling and Cytoskeletal Plasticity Coincides with the Loss of Cardiac Regenerative Capacity. CELLS 15 (10), 873 (2026)

Mintcheva, J.; Tseng, T.-L.; Goumenaki, P.; Neuschulz, A.; Senoussi, A.; Lelek, S.; Lim, K. L.; Ming, Z.; Schafer, R.; Hnatiuk, A. et al.; Ninov, N.; Beisaw, A.; McGrail, M.; Lai, S.-L. B.; Panakova, D.; Stainier, D. Y. R.; Junker, J. P.: In vivo single-cell RNA metabolic labeling resolves early transcriptional responders in the regenerating zebrafish heart. NATURE COMMUNICATIONS 17 (1), 4073 (2026)