Wissenschaftliche Publikationen

Bhingardeve, S.; Sagvekar, P.; Desai, S.; Mangoli, V.; Jagtap, R.; Mukherjee, S.: The regulatory interplay between miRNA and DNA methylation orchestrates vital ovarian functions and associated traits in PCOS. GENE 940, 149165 (2025)

Falcucci, L.; Dooley, C. M.; Adamoski, D.; Juan, T.; Martinez, J.; Georgieva, A. M.; Mamchaoui, K.; Cirzi, C.; Stainier, D. Y. R.: Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy. NATURE (639(8054)), S. 493 - 502 (2025)

Nawn, D.; Hassan, S. S.; Hromic-Jahjefendic, A.; Bhattacharya, T.; Basu, P.; Redwan, E. M.; Barh, D.; Andrade, B. S.; Aljabali, A. A.; Serrano-Aroca, A. et al.; Lundstrom, K.; Tambuwala, M. M.; Uversky, V. N.: Molecular genomic insights into melanoma associated proteins PRAME and BAP1. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2025)

Mikaeloff, F.; Gelpi, M.; Escos, A.; Wang, T.; Gupta, S.; Olofsson, A.; Akusjarvi, S. S.; Schuster, S.; Naval, P.; Sood, V. et al.; Nikouyan, N.; Knudsen, A. D.; Vestad, B.; Hogh, J.; Hov, J. R.; Benfield, T.; Troseid, M.; Pawar, V.; Rucevic, M.; Benfeitas, R.; Vegvari, A.; O'Mahony, L.; Savai, R.; Bjorkstrom, N. K.; Lourda, M.; de Magalhaes, J. P.; Weiss, S.; Mardinoglu, A.; Varshney, M. K.; Karlsson, A. C.; Syed, Y. A.; Nielsen, S. D.; Neogi, U.: Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo. ADVANCED SCIENCE (2025)

Khadim, A.; Kiliaris, G.; Vazquez-Armendariz, A. I.; Procida-Kowalski, T.; Glaser, D.; Bartkuhn, M.; Malik, T.; Chu, X.; Moiseenko, A.; Kuznetsova, I. et al.; Ahmadvand, N.; Lingampally, A.; Hadzic, S.; Alexopoulos, I.; Chen, Y.; Gueunther, A.; Behr, J.; Neumann, J.; Schiller, H. B.; Li, X.; Weissmann, N.; Braun, T.; Seeger, W.; Wygrecka, M.; Morty, R. E.; Herold, S.; El Agha, E.: Myofibroblasts emerge during alveolar regeneration following influenza-virus-induced lung injury. CELL REPORTS 44 (2), 115248 (2025)

Gupta, S.; Bajwa, G. K.; El-Sammak, H.; Mattonet, K.; Guenther, S.; Looso, M.; Stainier, D. Y. R.; Marin-Juez, R.: The transmembrane glycoprotein Gpnmb is required for the immune and fibrotic responses during zebrafish heart regeneration. DEVELOPMENTAL BIOLOGY 521, S. 153 - 162 (2025)

Juan, T.; Molina, T.; Xie, L.; Papadopoulou, S.; Cardoso, B.; Jha, S. G.; Stainier, D. Y. R.: A recombinase-activated ribozyme to knock down endogenous gene expression in zebrafish. PLOS GENETICS 21 (2), e1011594 (2025)

Kwon, J.; Haruya, K.; Mattonet, K.; Guenther, S.; Hahnefeld, L.; Shamsara, J.; Heering, J.; Kurz, M.; Kirchhofer, S.; Krasel, C. et al.; Ulrich, M.; Persechino, M.; Murthy, S.; Orlandi, C.; Sadik, C. D.; Geisslinger, G.; Buenemann, M.; Kolb, P.; Offermanns, S.; Wettschureck, N.: Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling. NATURE COMMUNICATIONS 16 (1), 1448 (2025)

Jin, Y.-J.; Liang, G.; Li, R.; Wang, S.; Alnouri, M. W.; Bentsen, M.; Kuenne, C.; Guenther, S.; Yan, Y.; Li, Y. et al.; Wettschureck, N.; Offermanns, S.: Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression. NATURE CARDIOVASCULAR RESEARCH 4 (2) (2025)

Su, M.; Zhao, W.; Jiang, H.; Zhao, Y.; Liao, Z.; Liu, Z.; Xu, M.; Jiang, S.; Wu, L.; Yang, Y. et al.; Wang, Z.; Zeng, Z.; Fang, Y.; Tang, C.; Miller, C. L.; Evans, P. C.; Wang, L.; Banach, M.; Jo, H.; Berk, B. C.; Offermanns, S.; Huang, Y.; Ge, J.; Xu, S.; Weng, J.: Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis. NATURE CARDIOVASCULAR RESEARCH 4 (2) (2025)

Eibach, Y.; Kreher, S.; Poetsch, M. S.; Kho, A. L.; Gaertner, U.; Clemen, C. S.; Schroeder, R.; Guo, K.; Milting, H.; Meder, B. et al.; Potente, M.; Richter, M.; Schneider, A.; Meiners, S.; Gaute, M.; Braun, T.: The deubiquitinase USP5 prevents accumulation of protein aggregates in cardiomyocytes. SCIENCE ADVANCES 11 (4), eado3852 (2025)

Hernandez-Olmos, V.; Heering, J.; Ildefeld, N.; Ehrler, J. H. M.; Kaps, A.; Rajkumar, R.; Marinescu, B.; Kaiser, A.; Macinkovic, I.; Elewa, M. A. F. et al.; Alnouri, M. W.; Elson, L.; Schubert-Zsilavecz, M.; Kallenborn-Gerhardt, W.; Schmidtko, A.; Mueller, S.; Offermanns, S.; Steinhilber, D.; Weigert, A.; Proschak, E.: Identification of a Chemical Probe for BLT2 Activation by Scaffold Hopping. JOURNAL OF MEDICINAL CHEMISTRY 68 (2), S. 1195 - 1221 (2025)

Juvik, B.; Falcucci, L.; Lundegaard, P. R.; Stainier, D. Y. R.: A new hypothesis to explain disease dominance. TRENDS IN GENETICS 41 (3), S. 187 - 193 (2025)

Funk, J. S.; Klimovich, M.; Drangenstein, D.; Pielhoop, O.; Hunold, P.; Borowek, A.; Noeparast, M.; Pavlakis, E.; Neumann, M.; Balourdas, D.-I. et al.; Kochhan, K.; Merle, N.; Bullwinkel, I.; Wanzel, M.; Elmshaeuser, S.; Teply-Szymanski, J.; Nist, A.; Procida, T.; Bartkuhn, M.; Humpert, K.; Mernberger, M.; Savai, R.; Soussi, T.; Joerger, A. C.; Stiewe, T.: Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations. NATURE GENETICS 57 (1) (2025)

Cordero, J.; Swaminathan, G.; Rogel-Ayala, D. G.; Rubio, K.; Elsherbiny, A.; Mahmood, S.; Szymanski, W.; Graumann, J.; Braun, T.; Guenther, S. et al.; Dobreva, G.; Barreto, G.: Nuclear microRNA 9 mediates G-quadruplex formation and 3D genome organization during TGF-β-induced transcription. NATURE COMMUNICATIONS 15 (1), 10711 (2024)

Kothalawala, S. D.; Guenther, S.; Schuppe, H.-C.; Pilatz, A.; Wagenlehner, F.; Kliesch, S.; O'Donnell, L.; Fietz, D.: Identification of differentially expressed genes in human testis biopsies with defective spermatogenesis. REPRODUCTIVE MEDICINE AND BIOLOGY 23 (1), e12616 (2024)

Liu, X.; Gu, L.; Hao, C.; Xu, W.; Leng, F.; Zhang, P.; Li, W.: Systematic assessment of structural variant annotation tools for genomic interpretation. LIFE SCIENCE ALLIANCE 8 (3), e202402949 (2024)

Xu, Y.; Gehlot, R.; Capon, S. J.; Albu, P. M.; Gretz, J.; Bloomekatz, J.; Mattonet, K.; Vucicevic, D.; Talyan, S.; Kikhi, K. et al.; Guenther, S.; Looso, M.; Firulli, B. A.; Sanda, M.; Firulli, A. B.; Lacadie, S. A.; Yelon, D.; Stainier, D. Y. R.: PDGFRA is a conserved HAND2 effector during early cardiac development. NATURE CARDIOVASCULAR RESEARCH 3 (12) (2024)

Xu, Y.; Gehlot, R.; Capon, S. J.; Albu, M.; Gretz, J.; Bloomekatz, J.; Mattonet, K.; Vucicevic, D.; Talyan, S.; Kikhi, K. et al.; Guenther, S.; Looso, M.; Firulli, B. A.; Sanda, M.; Firulli, A. B.; Lacadie, S. A.; Yelon, D.; Stainier, D. Y. R.: PDGFRA is a conserved HAND2 effector during early cardiac development. NATURE CARDIOVASCULAR RESEARCH 3 (12) (2024)

Wang, Z.-Y.; Mehra, A.; Wang, Q.-C.; Gupta, S.; da Silva, A. R.; Juan, T.; Guenther, S.; Looso, M.; Detleffsen, J.; Stainier, D. Y. R. et al.; Marin-Juez, R.: flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response. DEVELOPMENT 151 (23), dev203028 (2024)