Neurocardiac Axis
– Sympathetic Neuroimmunology in Heart Failure
The research group ‘Neurocardiac Axis – Sympathetic Neuroimmunology in Heart Failure’ led by Dr. Karin Ziegler focuses on the interface between neurology and cardiology, investigating the role of the sympathetic nervous system and the immune response in cardiovascular dysfunction. The aim is to develop new therapeutic strategies for cardiac diseases, with a particular focus on the role of peripheral sympathetic innervation in cardiac diseases.
Immunofluorescence image of a ganglion in a mouse with heart disease. The immune cells (macrophages) were marked red with an antibody, while the cell nuclei appear white. An area where many macrophages have accumulated is enlarged, indicating an immune response related to the heart disease.
© mpihlr
Spatial transcriptomics of the sympathetic ganglia of a mouse, shown at different zoom levels. Using Vizgen/MERSCOPE technology, 180 different genes were detected simultaneously – each in its own colour. The blue areas mark the cell nuclei, allowing the positions of the cells and the activity of the genes to be traced spatially.
© mpihlr
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