Cellular Resilience
Understanding how mitochondrial signalling enables cells to adapt and survive stress
The research group ‘Cellular Resilience Research Group’ led by Dr. Reymond Sutandy explores how cells maintain resilience under stress, with a particular emphasis on how mitochondria act as signaling organelles to coordinate adaptive responses.
Cells are continuously exposed to stress resulting from changes in their cellular environment, both under normal physiological conditions and in disease states. To maintain viability, cells must rapidly sense these changes and activate appropriate adaptive responses. The goal of the Sutandy lab is to understand how cells detect stress, regulate suitable response programs, and ultimately recover or adapt to challenging conditions. In particular, the research group focuses on the role of mitochondria as central metabolic and signaling hubs that coordinate cellular stress responses. Sutandys group investigates how mitochondria communicate with different cellular compartments to regulate stress adaptation at both the RNA and protein levels.
