Publications of Rajkumar Savai

Liu, H.; Tang, Y.; Singh, A.; Vong, J.; Cordero, J.; Mathes, A.; Gao, R.; Jia, Y.; Garvalov, B. K.; Acker, T. et al.; Poschet, G.; Hell, R.; Schneider, M. A.; Heineke, J.; Wieland, T.; Barreto, G.; Cerwenka, A.; Potente, M.; Bibli, S.-I.; Savai, R.; Dobreva, G.: RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α. NATURE COMMUNICATIONS 16 (1), 4929 (2025)

Better, J.; Estiri, M.; Wetstein, M.; Pervizaj-Oruqaj, L.; Malainou, C.; Ogungbemi-Alt, V.; Ferrero, M. R.; Langelage, M.; Kuznetsova, I.; Vazquez-Armendariz, A. I. et al.; Kimmig, L.; Pak, O.; Mansouri, S.; Savai, R.; Wilhelm, J.; Alexopoulos, I.; Sommer, N.; Herold, S.; Matt, U.: Cell type-specific efferocytosis determines functional plasticity of alveolar macrophages. SCIENCE IMMUNOLOGY 10 (107), eadl3852 (2025)

Gajawada, P.; Guenther, S.; Rolf, A.; Nabhanizadeh, J.; Savai, R.; Choi, Y.-H.; Richter, M.: Transcriptomic profiling of granuloma in patients with cardiac sarcoidosis. THERANOSTICS 15 (13), pp. 6044 - 6057 (2025)

Mikaeloff, F.; Gelpi, M.; Escos, A.; Wang, T.; Gupta, S.; Olofsson, A.; Akusjarvi, S. S.; Schuster, S.; Naval, P.; Sood, V. et al.; Nikouyan, N.; Knudsen, A. D.; Vestad, B.; Hogh, J.; Hov, J. R.; Benfield, T.; Troseid, M.; Pawar, V.; Rucevic, M.; Benfeitas, R.; Vegvari, A.; O'Mahony, L.; Savai, R.; Bjorkstrom, N. K.; Lourda, M.; de Magalhaes, J. P.; Weiss, S.; Mardinoglu, A.; Varshney, M. K.; Karlsson, A. C.; Syed, Y. A.; Nielsen, S. D.; Neogi, U.: Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo. ADVANCED SCIENCE (2025)

Funk, J. S.; Klimovich, M.; Drangenstein, D.; Pielhoop, O.; Hunold, P.; Borowek, A.; Noeparast, M.; Pavlakis, E.; Neumann, M.; Balourdas, D.-I. et al.; Kochhan, K.; Merle, N.; Bullwinkel, I.; Wanzel, M.; Elmshaeuser, S.; Teply-Szymanski, J.; Nist, A.; Procida, T.; Bartkuhn, M.; Humpert, K.; Mernberger, M.; Savai, R.; Soussi, T.; Joerger, A. C.; Stiewe, T.: Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations. NATURE GENETICS 57 (1) (2025)

Weiss, L. M.; Warwick, T.; Zehr, S.; Guenther, S.; Wolf, S.; Schmachtel, T.; Ponce, J. I.; Palfi, K.; Teichmann, T.; Schneider, A. et al.; Stoetzel, J.; Knapp, S.; Weigert, A.; Savai, R.; Rieger, M. A.; Oellerich, T.; Wittig, I.; Oo, J. A.; Brandes, R. P.; Leisegang, M. S.: RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions. COMMUNICATIONS BIOLOGY 7 (1), 1131 (2024)

Moghaddam, S. J.; Savai, R.; Salehi-Rad, R.; Sengupta, S.; Kammer, M. N.; Massion, P.; Beane, J. E.; Ostrin, E. J.; Priolo, C.; Tennis, M. A. et al.; Stabile, L. P.; Bauer, A. K.; Sears, C. R.; Szabo, E.; Rivera, M. P.; Powell, C. A.; Kadara, H.; Jenkins, B. J.; Dubinett, S. M.; Houghton, A. M.; Kim, C. F.; Keith, R. L.: Premalignant Progression in the Lung: Knowledge Gaps and Novel Opportunities for Interception of Non-Small Cell Lung Cancer An Official American Thoracic Society Research Statement. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 210 (5), pp. 548 - 571 (2024)

Cekay, M.; Arndt, P. F.; Franken, J. K.; Wilhelm, J.; Pullamsetti, S. S.; Roller, F. C.; Sommer, N.; Askevold, I.; Luedecke, G.; Langer, C. et al.; Stein, M.; Zeppernick, F.; Tello, K.; Sibelius, U.; Grimminger, F.; Seeger, W.; Savai, R.; Eul, B.: Non-invasive surrogate markers of pulmonary hypertension are associated with poor survival in patients with cancer. BMJ OPEN RESPIRATORY RESEARCH 11 (1), e001916 (2024)

Flaxman, H. A.; Chrysovergi, M.-A.; Han, H.; Kabir, F.; Lister, R. T.; Chang, C.-F.; Yvon, R.; Black, K. E.; Weigert, A.; Savai, R. et al.; Egea-Zorrilla, A.; Pardo-Saganta, A.; Lagares, D.; Woo, C. M.: Sanglifehrin A mitigates multiorgan fibrosis by targeting the collagen chaperone cyclophilin B. JCI INSIGHT 9 (15), e171162 (2024)

Kumari, P.; Tarighi, S.; Fuchshuber, E.; Li, L.; Fernandez-Duran, I.; Wang, M.; Ayoson, J.; Castello-Garcia, J. M.; Gamez-Garcia, A.; Espinosa-Alcantud, M. et al.; Sreenivasan, K.; Guenther, S.; Olivella, M.; Savai, R.; Yue, S.; Vaquero, A.; Braun, T.; Ianni, A.: SIRT7 promotes lung cancer progression by destabilizing the tumor suppressor ARF. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (25), e2409269121 (2024)

Budczies, J.; Romanovsky, E.; Kirchner, M.; Neumann, O.; Blasi, M.; Schnorbach, J.; Shah, R.; Bozorgmehr, F.; Savai, R.; Stiewe, T. et al.; Peters, S.; Schirmacher, P.; Thomas, M.; Kazdal, D.; Christopoulos, P.; Stenzinger, A.: KRAS and TP53 co-mutation predicts benefit of immune checkpoint blockade in lung adenocarcinoma. BRITISH JOURNAL OF CANCER (2024)

Turkowski, K.; Herzberg, F.; Guenther, S.; Weigert, A.; Haselbauer, T.; Fink, L.; Brunn, D.; Grimminger, F.; Seeger, W.; Sueltmann, H. et al.; Stiewe, T.; Pullamsetti, S. S.; Savai, R.: miR-147b mediated suppression of DUSP8 promotes lung cancer progression. ONCOGENE (2024)

Baig, M. S.; Barmpoutsi, S.; Bharti, S.; Weigert, A.; Hirani, N.; Atre, R.; Khabiya, R.; Sharma, R.; Sarup, S.; Savai, R.: Adaptor molecules mediate negative regulation of macrophage inflammatory pathways: a closer look. FRONTIERS IN IMMUNOLOGY 15, 1355012 (2024)

Eichhorn, F.; Weigert, A.; Nandigama, R.; Klotz V, L.; Kriegsmann, M.; Allgaeuer, M.; Muley, T.; Christopoulos, P.; Savai, R.; Eichhorn, M. E. et al.; Winter, H.: Prognostic Impact of the Immune-Cell Infiltrate in N1-Positive Non-Small-Cell Lung Cancer. CLINICAL LUNG CANCER 24 (8) (2023)

Hirani, D. V.; Thielen, F.; Mansouri, S.; Danopoulos, S.; Vohlen, C.; Haznedar-Karakaya, P.; Mohr, J.; Wilke, R.; Selle, J.; Grosch, T. et al.; Mizik, I.; Odenthal, M.; Alvira, C. M.; Kuiper-Makris, C.; Pryhuber, G. S.; Pallasch, C.; van Koningsbruggen-Rietschel, S.; Al-Alam, D.; Seeger, W.; Savai, R.; Doetsch, J.; Alcazar, M. A. A.: CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia. INFLAMMATION AND REGENERATION 43 (1), 52 (2023)

Seker-Cin, H.; Tay, T. K. Y.; Kazdal, D.; Kluck, K.; Ball, M.; Neumann, O.; Winter, H.; Herth, F.; Heussel, C.-P.; Savai, R. et al.; Schirmacher, P.; Thomas, M.; Budczies, J.; Allgaeuer, M.; Christopoulos, P.; Stenzinger, A.; Volckmar, A.-L.: Analysis of rare fusions in NSCLC: Genomic architecture and clinical implications. LUNG CANCER 184, 107317 (2023)

Khassafi, F.; Chelladurai, P.; Valasarajan, C.; Nayakanti, S. R.; Martineau, S.; Sommer, N.; Yokokawa, T.; Boucherat, O.; Kamal, A.; Kiely, D. G. et al.; Swift, A. J.; Alabed, S.; Omura, J.; Breuils-Bonnet, S.; Kuenne, C.; Potus, F.; Guenther, S.; Savai, R.; Seeger, W.; Looso, M.; Zaugg, J. B.; Tello, K.; Provencher, S.; Bonnet, S.; Pullamsetti, S. S.: Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension. NATURE CARDIOVASCULAR RESEARCH 2 (10), pp. 917 - + (2023)

Karger, A.; Mansouri, S.; Leisegang , M. S.; Weigert, A.; Guenther, S.; Kuenne, C.; Wittig , I.; Zukunft , S.; Klatt , S.; Aliraj , B. et al.; Klotz V , L.; Winter , H.; Mahavadi, P.; Fleming , I.; Ruppert , C.; Witte , B.; Alkoudmani , I.; Gattenloehner, S.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: ADPGK-AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth. EMBO JOURNAL (2023)

Zheng, X.; Sarode, P.; Weigert , A.; Turkowski, K.; Chelladurai, P.; Guenther, S.; Kuenne, C.; Winter , H.; Stenzinger, A.; Reu, S. et al.; Grimminger, F.; Stiewe, T.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: The HDAC2-SP1 Axis Orchestrates Protumor Macrophage Polarization. CANCER RESEARCH 83 (14), pp. 2345 - 2357 (2023)

Goldschmid, H.; Kluck, K.; Ball, M.; Kirchner, M.; Allgaeuer, M.; Winter, H.; Herth, F.; Heussel, C.-P.; Pullamsetti, S. S.; Savai, R. et al.; Yong, T. T. K.; Schirmacher, P.; Peters, S.; Thomas, M.; Christopoulos, P.; Budczies, J.; Stenzinger, A.; Kazdal, D.: Spatial profiling of the microenvironment reveals low intratumoral heterogeneity and STK11-associated immune evasion in therapy-naive lung adenocarcinomas. LUNG CANCER 180, 107212 (2023)