Publications of Rajkumar Savai

Pullamsetti, S. S.; Kojonazarov, B.; Storn, S.; Gall, H.; Salazar, Y.; Wolf, J.; Weigert, A.; El-Nikhely, N.; Ghofrani, H. A.; Krombach, G. A. et al.; Fink, L.; Gattenlohner, S.; Rapp, U. R.; Schermuly, R. T.; Grimminger, F.; Seeger, W.; Savai, R.: Lung cancer-associated pulmonary hypertension: Role of microenvironmental inflammation based on tumor cell-immune cell cross-talk. SCIENCE TRANSLATIONAL MEDICINE 9 (416), eaai9048 (2017)

Pullamsetti, S. S.; Savai, R.: Macrophage Regulation during Vascular Remodeling: Implications for Pulmonary Hypertension Therapy. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 56 (5), pp. 556 - 558 (2017)

Pullamsettit, S. S.; Savai, R.; Seeger, W.; Goncharova, E. A.: From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics Targeting Cell Growth and Proliferation Signaling Hubs. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 195 (4), pp. 425 - 437 (2017)

Savai, R.; Asafova, A.; Zheng, X.; Schmall, A.; Weigert, A.; Pullamsetti, S. S.; Seeger, W.: Circulating Fibrocytes Depletion Results In Reduced Lung Tumor Growth And Metastasis By Modulating Macrophage Phenotype, Angiogenesis And Endothelin System. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 195 (2017)

Weichand, B.; Popp, R.; Dziumbla, S.; Mora, J.; Strack, E.; Elwakeel, E.; Frank, A.-C.; Scholich, K.; Pierre, S.; Syed, S. N. et al.; Olesch, C.; Ringleb, J.; Oeren, B.; Doering, C.; Savai, R.; Jung, M.; von Knethen, A.; Levkau, B.; Fleming, I.; Weigert, A.; Bruene, B.: S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1 beta. JOURNAL OF EXPERIMENTAL MEDICINE 214 (9), pp. 2695 - 2713 (2017)

Zheng, X.; Sarode, P.; Weigert, A.; Guenther, S.; Chelladurai, P.; Pullamsetti, S. S.; Seeger, W.; Savai, R.: Re-Education Of Tumor-Associated Macrophages By Modulating Histone Deacetylases In Lung Cancer. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 195 (2017)

Zheng, X.; Turkowski, K.; Mora, J.; Brne, B.; Seeger, W.; Weigert, A.; Savai, R.: Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy. ONCOTARGET 8 (29), pp. 48436 - 48452 (2017)

Dabral, S.; Muecke, C.; Schmoranzer, M.; Valsarajan, C.; Wietelmann, A.; Savai, R.; Seeger, W.; Dammann, R.; Pullamsetti, S. S.: Rassf1a Regulates Ros-Hif Axis In Hypoxia Driven Pulmonary Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 193 (2016)

Dabral, S.; Muecke, C.; Schmoranzer, M.; Valsarajan, C.; Wietelmann, A.; Savai, R.; Seeger, W.; Dammann, R.; Pullamsetti, S. S.: Rassf1a Regulates Ros-Hif Axis In Hypoxia Driven Pulmonary Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 193 (2016)

Dabral, S.; Tian, X.; Kojonazarov, B.; Savai, R.; Ghofrani, H. A.; Weissmann, N.; Florio, M.; Sun, J.; Jonigk, D.; Maegel, L. et al.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Schermuly, R. T.: Notch1 signalling regulates endothelial proliferation and apoptosis in pulmonary arterial hypertension. EUROPEAN RESPIRATORY JOURNAL 48 (4), pp. 1137 - 1149 (2016)

Ghanbari, P.; Wheeler, M.; Stubenvoll, A.; Braun, T.; Savai, R.: The role of emerin in coupling Wnt/beta-catenin signalling to genomic instability in cancer. MOLECULAR BIOLOGY OF THE CELL 27 (2016)

Ghanbari, P.; Wheeler, M.; Stubenvoll, A.; Braun, T.; Savai, R.: The role of emerin in coupling Wnt/beta-catenin signalling to genomic instability in cancer. MOLECULAR BIOLOGY OF THE CELL 27 (2016)

Mehta, A.; Cordero Henriquez, J. D.; Dobersch, S.; Romero-Olmedo, Addi J. (Max Planck Institute for Heart and Lung Research, Lung Cancer Epigenetics), A. J.; Savai, R.; Bodner, J.; Chao, C.-M.; Fink, L.; Guzman-Diaz, E.; Singh, I. et al.; Dobreva, G.; Rapp, U. R.; Guenther, S.; Ilinskaya, O. N.; Bellusci, S.; Dammann, R. H.; Braun, T.; Seeger, W.; Gattenloehner, S.; Tresch, A.; Guenther, A.; Barreto, G.: Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate. EMBO MOLECULAR MEDICINE 8 (12), pp. 1380 - 1389 (2016)

Wanzel, I.; Vischedyk, J. B.; Gittler, M. P.; Gremke, N.; Seiz, J. R.; Hefter, M.; Noack, M.; Savai, R.; Mernberger, M.; Charles, J. P. et al.; Schneikert, J.; Bretz, A. C.; Nist, A.; Stiewe, T.: CRISPR-Cas9-based target validation for p53-reactivating model compounds. NATURE CHEMICAL BIOLOGY 12 (1), pp. 22 - + (2016)

Wanzel, I.; Vischedyk, J. B.; Gittler, M. P.; Gremke, N.; Seiz, J. R.; Hefter, M.; Noack, M.; Savai, R.; Mernberger, M.; Charles, J. P. et al.; Schneikert, J.; Bretz, A. C.; Nist, A.; Stiewe, T.: CRISPR-Cas9-based target validation for p53-reactivating model compounds. NATURE CHEMICAL BIOLOGY 12 (1), pp. 22 - + (2016)