Publications of Rajkumar Savai

Neogi, U.; Ambikan, A. T.; Turkowski, K.; Schneider, M. A.; Beutgen, V. M.; Graumann, J.; Winter, H.; Bartkuhn, M.; Seeger, W.; Pullamsetti, S. S. et al.; Savai, R.: Plasma proteomic profiling and molecular clustering reveal immune-defined prognostic subtypes in lung adenocarcinoma. INTERNATIONAL JOURNAL OF CANCER (2025)

Mansouri, S.; Karger, A.; Ruppert, C.; Schneider, M. A.; Weigert, A.; Nandigama, R.; Aliraj, B.; Strotmann, L.; Cherian, A. V.; Pruefer, D. et al.; Dorfmuller, P.; Fink, L.; Alkoudmani, I.; Gattenlohner, S.; Eul, B.; Althoff, A.; Kleine, P.; Winter, H.; Guenther, A.; Ghofrani, H.-A.; Pullamsetti, S. S.; Grimminger, F.; Seeger, W.; Savai, R.: Living human lung slices for ex vivo modelling of lung cancer. JCI INSIGHT 10 (17), e190703 (2025)

Eichhorn, M. E.; Niedermaier, B.; Charoentong, P.; Klotz V, L.; Baum, P.; Griffo, R.; Allgaeuer, M.; Stenzinger, A.; Bischoff, H.; Schneider, M. A. et al.; Christopoulos, P.; Haberkorn, U.; Heussel, C.-P.; Savai, R.; Roberti, M. P.; Zoernig, I.; Jaeger, D.; Herth, F.; Thomas, M.; Winter, H.; Eichhorn, F.: Neoadjuvant anti-programmed death-1 immunotherapy by pembrolizumab in resectable non-small cell lung cancer: results of the NEOMUN trial. JOURNAL FOR IMMUNOTHERAPY OF CANCER 13 (8), e011874 (2025)

Rako, Z. A.; Cekay, M.; Yogeswaran, A.; Yildiz, S.; Arndt, P. F.; Kremer, N.; Schaefer, S.; Janetzko, P.; Thal, B. R.; Mummert, C. M. et al.; Franken, J. K.; Soethe, H.; Werner, H. F.; Dumitrascu, R.; Grimminger, F.; Ghofrani, H. A.; Pullamsetti, S. S.; Seeger, W.; Naeije, R.; Savai, R.; Eul, B.; Tello, K.: Echocardiographic Measure of Right Ventricular-Pulmonary Arterial Coupling Predicts Survival in Lung Cancer. ANNALS OF THE AMERICAN THORACIC SOCIETY 22 (7), pp. 1071 - 1078 (2025)

Ruiz, V. M. G.; Khabaza, A.; Bauer, R.; Aliraj, B.; Mansouri, S.; Meyer, S. P.; Palmer, M. A.; Winter, H.; V. Klotz, L.; Elewa, M. A. F. et al.; Kur, I. M.; Angioni, C.; Mojaradfar, R.; Hahnefeld, L.; Savai, R.; Fuhrmann, D.; Weigert, A.; Brune, B.: Macrophage fatty acid metabolism under chronic hypoxia shapes γS T cell recruitment via CCL22. ISCIENCE 28 (8), 113025 (2025)

Liu, H.; Tang, Y.; Singh, A.; Vong, J.; Cordero, J.; Mathes, A.; Gao, R.; Jia, Y.; Garvalov, B. K.; Acker, T. et al.; Poschet, G.; Hell, R.; Schneider, M. A.; Heineke, J.; Wieland, T.; Barreto, G.; Cerwenka, A.; Potente, M.; Bibli, S.-I.; Savai, R.; Dobreva, G.: RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α. NATURE COMMUNICATIONS 16 (1), 4929 (2025)

Better, J.; Estiri, M.; Wetstein, M.; Pervizaj-Oruqaj, L.; Malainou, C.; Ogungbemi-Alt, V.; Ferrero, M. R.; Langelage, M.; Kuznetsova, I.; Vazquez-Armendariz, A. I. et al.; Kimmig, L.; Pak, O.; Mansouri, S.; Savai, R.; Wilhelm, J.; Alexopoulos, I.; Sommer, N.; Herold, S.; Matt, U.: Cell type-specific efferocytosis determines functional plasticity of alveolar macrophages. SCIENCE IMMUNOLOGY 10 (107), eadl3852 (2025)

Gajawada, P.; Guenther, S.; Rolf, A.; Nabhanizadeh, J.; Savai, R.; Choi, Y.-H.; Richter, M.: Transcriptomic profiling of granuloma in patients with cardiac sarcoidosis. THERANOSTICS 15 (13), pp. 6044 - 6057 (2025)

Mikaeloff, F.; Gelpi, M.; Escos, A.; Wang, T.; Gupta, S.; Olofsson, A.; Akusjarvi, S. S.; Schuster, S.; Naval, P.; Sood, V. et al.; Nikouyan, N.; Knudsen, A. D.; Vestad, B.; Hogh, J.; Hov, J. R.; Benfield, T.; Troseid, M.; Pawar, V.; Rucevic, M.; Benfeitas, R.; Vegvari, A.; O'Mahony, L.; Savai, R.; Bjorkstrom, N. K.; Lourda, M.; de Magalhaes, J. P.; Weiss, S.; Mardinoglu, A.; Varshney, M. K.; Karlsson, A. C.; Syed, Y. A.; Nielsen, S. D.; Neogi, U.: Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo. ADVANCED SCIENCE (2025)

Funk, J. S.; Klimovich, M.; Drangenstein, D.; Pielhoop, O.; Hunold, P.; Borowek, A.; Noeparast, M.; Pavlakis, E.; Neumann, M.; Balourdas, D.-I. et al.; Kochhan, K.; Merle, N.; Bullwinkel, I.; Wanzel, M.; Elmshaeuser, S.; Teply-Szymanski, J.; Nist, A.; Procida, T.; Bartkuhn, M.; Humpert, K.; Mernberger, M.; Savai, R.; Soussi, T.; Joerger, A. C.; Stiewe, T.: Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations. NATURE GENETICS 57 (1) (2025)

Weiss, L. M.; Warwick, T.; Zehr, S.; Guenther, S.; Wolf, S.; Schmachtel, T.; Ponce, J. I.; Palfi, K.; Teichmann, T.; Schneider, A. et al.; Stoetzel, J.; Knapp, S.; Weigert, A.; Savai, R.; Rieger, M. A.; Oellerich, T.; Wittig, I.; Oo, J. A.; Brandes, R. P.; Leisegang, M. S.: RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions. COMMUNICATIONS BIOLOGY 7 (1), 1131 (2024)

Moghaddam, S. J.; Savai, R.; Salehi-Rad, R.; Sengupta, S.; Kammer, M. N.; Massion, P.; Beane, J. E.; Ostrin, E. J.; Priolo, C.; Tennis, M. A. et al.; Stabile, L. P.; Bauer, A. K.; Sears, C. R.; Szabo, E.; Rivera, M. P.; Powell, C. A.; Kadara, H.; Jenkins, B. J.; Dubinett, S. M.; Houghton, A. M.; Kim, C. F.; Keith, R. L.: Premalignant Progression in the Lung: Knowledge Gaps and Novel Opportunities for Interception of Non-Small Cell Lung Cancer An Official American Thoracic Society Research Statement. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 210 (5), pp. 548 - 571 (2024)

Cekay, M.; Arndt, P. F.; Franken, J. K.; Wilhelm, J.; Pullamsetti, S. S.; Roller, F. C.; Sommer, N.; Askevold, I.; Luedecke, G.; Langer, C. et al.; Stein, M.; Zeppernick, F.; Tello, K.; Sibelius, U.; Grimminger, F.; Seeger, W.; Savai, R.; Eul, B.: Non-invasive surrogate markers of pulmonary hypertension are associated with poor survival in patients with cancer. BMJ OPEN RESPIRATORY RESEARCH 11 (1), e001916 (2024)

Flaxman, H. A.; Chrysovergi, M.-A.; Han, H.; Kabir, F.; Lister, R. T.; Chang, C.-F.; Yvon, R.; Black, K. E.; Weigert, A.; Savai, R. et al.; Egea-Zorrilla, A.; Pardo-Saganta, A.; Lagares, D.; Woo, C. M.: Sanglifehrin A mitigates multiorgan fibrosis by targeting the collagen chaperone cyclophilin B. JCI INSIGHT 9 (15), e171162 (2024)

Kumari, P.; Tarighi, S.; Fuchshuber, E.; Li, L.; Fernandez-Duran, I.; Wang, M.; Ayoson, J.; Castello-Garcia, J. M.; Gamez-Garcia, A.; Espinosa-Alcantud, M. et al.; Sreenivasan, K.; Guenther, S.; Olivella, M.; Savai, R.; Yue, S.; Vaquero, A.; Braun, T.; Ianni, A.: SIRT7 promotes lung cancer progression by destabilizing the tumor suppressor ARF. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (25), e2409269121 (2024)

Budczies, J.; Romanovsky, E.; Kirchner, M.; Neumann, O.; Blasi, M.; Schnorbach, J.; Shah, R.; Bozorgmehr, F.; Savai, R.; Stiewe, T. et al.; Peters, S.; Schirmacher, P.; Thomas, M.; Kazdal, D.; Christopoulos, P.; Stenzinger, A.: KRAS and TP53 co-mutation predicts benefit of immune checkpoint blockade in lung adenocarcinoma. BRITISH JOURNAL OF CANCER (2024)

Turkowski, K.; Herzberg, F.; Guenther, S.; Weigert, A.; Haselbauer, T.; Fink, L.; Brunn, D.; Grimminger, F.; Seeger, W.; Sueltmann, H. et al.; Stiewe, T.; Pullamsetti, S. S.; Savai, R.: miR-147b mediated suppression of DUSP8 promotes lung cancer progression. ONCOGENE (2024)

Baig, M. S.; Barmpoutsi, S.; Bharti, S.; Weigert, A.; Hirani, N.; Atre, R.; Khabiya, R.; Sharma, R.; Sarup, S.; Savai, R.: Adaptor molecules mediate negative regulation of macrophage inflammatory pathways: a closer look. FRONTIERS IN IMMUNOLOGY 15, 1355012 (2024)

Eichhorn, F.; Weigert, A.; Nandigama, R.; Klotz V, L.; Kriegsmann, M.; Allgaeuer, M.; Muley, T.; Christopoulos, P.; Savai, R.; Eichhorn, M. E. et al.; Winter, H.: Prognostic Impact of the Immune-Cell Infiltrate in N1-Positive Non-Small-Cell Lung Cancer. CLINICAL LUNG CANCER 24 (8) (2023)

Hirani, D. V.; Thielen, F.; Mansouri, S.; Danopoulos, S.; Vohlen, C.; Haznedar-Karakaya, P.; Mohr, J.; Wilke, R.; Selle, J.; Grosch, T. et al.; Mizik, I.; Odenthal, M.; Alvira, C. M.; Kuiper-Makris, C.; Pryhuber, G. S.; Pallasch, C.; van Koningsbruggen-Rietschel, S.; Al-Alam, D.; Seeger, W.; Savai, R.; Doetsch, J.; Alcazar, M. A. A.: CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia. INFLAMMATION AND REGENERATION 43 (1), 52 (2023)