Publications of Rajkumar Savai

Sarode, P.; Schaefer, M. B.; Grimminger, F.; Seeger, W.; Savai, R.: Macrophage and Tumor Cell Cross-Talk Is Fundamental for Lung Tumor Progression: We Need to Talk. FRONTIERS IN ONCOLOGY 10, 324 (2020)

Sarode, P.; Zheng, X.; Giotopoulou, G. A.; Weigert, A.; Kuenne, C.; Guenther, S.; Friedrich, A.; Gattenloehner, S.; Stiewe, T.; Bruene, B. et al.; Grimminger, F.; Stathopoulos, G. T.; Pullamsetti, S. S.; Seeger, W.; Savai, R.: Reprogramming of tumor-associated macrophages by targeting beta-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer. SCIENCE ADVANCES 6 (23), eaaz6105 (2020)

Turkowski, K.; Herzberg, F.; Guenther, S.; Brunn, D.; Weigert, A.; Meister, M.; Muley, T.; Kriegsmann, M.; Schneider, M. A.; Winter, H. et al.; Thomas, M.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: Fibroblast Growth Factor-14 Acts as Tumor Suppressor in Lung Adenocarcinomas. CELLS 9 (8), 1755 (2020)

Zheng, X.; Weigert, A.; Reu, S.; Guenther, S.; Mansouri, S.; Bassaly, B.; Gattenlohner, S.; Grimminger, F.; Pullamsetti, S. S.; Seeger, W. et al.; Winter, H.; Savai, R.: Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non-Small Cell Lung Carcinoma. CANCER RESEARCH 80 (20), pp. 4414 - 4425 (2020)

Dabral, S.; Muecke, C.; Valasarajan, C.; Schmoranzer, M.; Wietelmann, A.; Semenza, G. L.; Meister, M.; Muley, T.; Seeger-Nukpezah, T.; Samakovlis, C. et al.; Weissmann, N.; Grimminger, F.; Seeger, W.; Savai, R.; Pullamsetti, S. S.: A RASSF1A-HIF1 alpha loop drives Warburg effect in cancer and pulmonary hypertension. NATURE COMMUNICATIONS 10, 2130 (2019)

Elwakeel, E.; Brueggemann, M.; Fink, A. F.; Schulz, M. H.; Schmid, T.; Savai, R.; Bruene, B.; Zarnack, K.; Weigert, A.: Phenotypic Plasticity of Fibroblasts during Mammary Carcinoma Development. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20 (18), 4438 (2019)

Hempel, F.; Roderfeld, M.; Savai, R.; Sydykov, A.; Irungbam, K.; Schermuly, R.; Voswinckel, R.; Koehler, K.; Churin, Y.; Kiss, L. et al.; Bier, J.; Pons-Kuehnemann, J.; Roeb, E.: Depletion of Bone Marrow-Derived Fibrocytes Attenuates TAA-Induced Liver Fibrosis in Mice. CELLS 8 (10), 1210 (2019)

Jia, Y.; Vong, J. S.-L.; Asafova, A.; Garvalov, B. K.; Caputo, L.; Cordero, J.; Singh, A.; Boettger, T.; Guenther, S.; Fink, L. et al.; Acker, T.; Barreto, G.; Seeger, W.; Braun, T.; Savai, R.; Dobreva, G.: Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET. JOURNAL OF EXPERIMENTAL MEDICINE 216 (6), pp. 1377 - 1395 (2019)

Rubio, K.; Singh, I.; Dobersch, S.; Sarvari, P.; Guenther, S.; Cordero, J.; Mehta, A.; Wujak, L.; Cabrera-Fuentes, H.; Chao, C.-M. et al.; Braubach, P.; Bellusci, S.; Seeger, W.; Guenther, A.; Preissner, K. T.; Wygrecka, M.; Savai, R.; Papy-Garcia, D.; Dobreva, G.; Heikenwalder, M.; Savai-Pullamsetti, S.; Braun, T.; Barreto, G.: Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis. NATURE COMMUNICATIONS 10, 2229 (2019)

Saqib, U.; Savai, R.; Liu, D.; Banerjee, S.; Baig, M. S.: Drug repositioning as an effective therapy for protease-activated receptor 2 inhibition. JOURNAL OF CELLULAR BIOCHEMISTRY 120 (2), pp. 1522 - 1526 (2019)

Saul, M. J.; Baumann, I.; Bruno, A.; Emmerich, A. C.; Wellstein, J.; Ottinger, S. M.; Contursi, A.; Dovizio, M.; Donnini, S.; Tacconelli, S. et al.; Raouf, J.; Idborg, H.; Stein, S.; Korotkova, M.; Savai, R.; Terzuoli, E.; Sala, G.; Seeger, W.; Jakobsson, P.-J.; Patrignani, P.; Suess, B.; Steinhilber, D.: miR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction. FASEB JOURNAL 33 (6), pp. 6933 - 6947 (2019)

Solimani, F.; Pollmann, R.; Schmidt, T.; Schmidt, A.; Zheng, X.; Savai, R.; Muehlenbein, S.; Pickert, J.; Eubel, V.; Moebs, C. et al.; Eming, R.; Hertl, M.: Therapeutic Targeting of Th17/Tc17 Cells Leads to Clinical Improvement of Lichen Planus. FRONTIERS IN IMMUNOLOGY 10, 1808 (2019)

Al-Tamari, H. M.; Dabral, S.; Schmall, A.; Sarvari, P.; Ruppert, C.; Paik, J.; DePinho, R. A.; Grimminger, F.; Eickelberg, O.; Guenther, A. et al.; Seeger, W.; Savai, R.; Pullamsetti, S. S.: FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis. EMBO MOLECULAR MEDICINE 10 (2), pp. 276 - 293 (2018)

Baig, M. S.; Roy, A.; Saqib, U.; Rajpoot, S.; Srivastava, M.; Naim, A.; Liu, D.; Saluja, R.; Faisal, S. M.; Pan, Q. et al.; Turkowski, K.; Darwhekar, G. N.; Savai, R.: Repurposing Thioridazine (TDZ) as an anti-inflammatory agent. SCIENTIFIC REPORTS 8, 12471 (2018)

Brunn, D.; Grimminger, F.; Seeger, W.; Savai, R.: Interferon Regulatory Factor 9 Mediated Regulation of Lung Cancer Progression and Metastasis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 197 (2018)

Pullamsetti, S. S.; Seeger, W.; Savai, R.: Classical IL-6 signaling: a promising therapeutic target for pulmonary arterial hypertension. JOURNAL OF CLINICAL INVESTIGATION 128 (5), pp. 1720 - 1723 (2018)

Saqib, U.; Kelley, T. T.; Panguluri, S. K.; Liu, D.; Savai, R.; Baig, M. S.; Schurer, S. C.: Polypharmacology or Promiscuity? Structural Interactions of Resveratrol With Its Bandwagon of Targets. FRONTIERS IN PHARMACOLOGY 9, 1201 (2018)

Sarode, P.; Zheng, X.; Weigert, A.; Tretyn, A.; Guenther, S.; Pullamsetti, S. S.; Grimminger, F.; Seeger, W.; Savai, R.: Reprogramming of Tumor Associated Macrophages by Modulating Wnt beta-Catenin Signalling in Lung Cancer. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 197 (2018)

Turkowski, K.; Haselbauer, T.; Kaduthanam, S.; Sueltmann, H.; Grimminger, F.; Seeger, W.; Savai, R.: Macrophage and Cancer Cell Crosstalk Regulated MicroRNA 147b Plays a Crucial Role in Lung Cancer Progression. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 197 (2018)

Kiehl, S.; Zimmermann, T.; Savai, R.; Pullamsetti, S. S.; Seeger, W.; Bartkuhn, M.; Dammann, R. H.: Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer. SCIENTIFIC REPORTS 7, 3896 (2017)