Publications of Rajkumar Savai

Hirani, D.; Alvira, C. M.; Danopoulos, S.; Milla, C.; Donato, M.; Tian, L.; Mohr, J.; Dinger, K.; Vohlen, C.; Selle, J. et al.; Koningsbruggen-Rietschel V, S.; Barbarino, V.; Pallasch, C.; Rose-John, S.; Odenthal, M.; Pryhuber, G. S.; Mansouri, S.; Savai, R.; Seeger, W.; Khatri, P.; Al Alam, D.; Doetsch, J.; Alcazar, M. A. A.: Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia. EUROPEAN RESPIRATORY JOURNAL 59 (2), 2002248 (2022)

Olesch, C.; Brunn, D.; Aktay-Cetin, O.; Sirait-Fischer, E.; Pullamsetti, S. S.; Grimminger, F.; Seeger, W.; Bruene, B.; Weigert, A.; Savai, R.: Picturing of the Lung Tumor Cellular Composition by Multispectral Flow Cytometry. FRONTIERS IN IMMUNOLOGY 13, 827719 (2022)

Avci, E.; Sarvari, P.; Savai, R.; Seeger, W.; Pullamsetti, S. S.: Epigenetic Mechanisms in Parenchymal Lung Diseases: Bystanders or Therapeutic Targets? INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 (1), 546 (2022)

Rajpoot, S.; Solanki, K.; Kumar, A.; Zhang, K. Y. J.; Pullamsetti, S. S.; Savai, R.; Faisal, S. M.; Pan, Q.; Baig, M. S.: In-Silico Design of a Novel Tridecapeptide Targeting Spike Protein of SARS-CoV-2 Variants of Concern. INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS 28 (1), 28 (2021)

Berghausen, E. M.; Janssen, W.; Vantler, M.; Gnatzy-Feik, L. L.; Krause, M.; Behringer, A.; Joseph, C.; Zierden, M.; ten Freyhaus, H.; Klinke, A. et al.; Baldus, S.; Alcazar, M. A.; Savai, R.; Pullamsetti, S. S.; Wong, D. W. L.; Boor, P.; Zhao, J. J.; Schermuly, R. T.; Rosenkranz, S.: Disrupted PI3K subunit p110 alpha signaling protects against pulmonary hypertension and reverses established disease in rodents. JOURNAL OF CLINICAL INVESTIGATION 131 (19), e136939 (2021)

Donzelli, J.; Proestler, E.; Riedel, A.; Nevermann, S.; Hertel, B.; Guenther, A.; Gattenloehner, S.; Savai, R.; Larsson, K.; Saul, M. J.: Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer. JOURNAL OF EXTRACELLULAR VESICLES 10 (12), 12143 (2021)

Karger, A.; Nandigama, R.; Stenzinger, A.; Grimminger, F.; Pullamsetti, S. S.; Seeger, W.; Savai, R.: Hidden Treasures: Macrophage Long Non-Coding RNAs in Lung Cancer Progression. CANCERS 13 (16), 4127 (2021)

Padmasekar, M.; Savai, R.; Seeger, W.; Pullamsetti, S. S.: Exposomes to Exosomes: Exosomes as Tools to Study Epigenetic Adaptive Mechanisms in High-Altitude Humans. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 18 (16), 8280 (2021)

Eichhorn, F.; Klotz V, L.; Kriegsmann, M.; Bischoff, H.; Schneider, M. A.; Muley, T.; Kriegsmann, K.; Haberkorn, U.; Heussel, C. P.; Savai, R. et al.; Zoernig, I.; Jaeger, D.; Thomas, M.; Hoffmann, H.; Winter, H.; Eichhorn, M. E.: Neoadjuvant anti-programmed death-1 immunotherapy by pembrolizumab in resectable non-small cell lung cancer: First clinical experience. LUNG CANCER 153, pp. 150 - 157 (2021)

Brunn, D.; Turkowski, K.; Gunther, S.; Weigert, A.; Muley, T.; Kriegsmann, M.; Winter, H.; Dammann, R. H.; Stathopoulos, G. T.; Thomas, M. et al.; Guenther, A.; Grimminger, F.; Pullamsetti, S. S.; Seeger, W.; Savai, R.: Interferon Regulatory Factor 9 Promotes Lung Cancer Progression via Regulation of Versican. CANCERS 13 (2), 208 (2021)

Fink, C.; Baal, N.; Wilhelm, J.; Sarode, P.; Weigel, R.; Schumacher, V.; Nettersheim, D.; Schorle, H.; Schroeck, C.; Bergmann, M. et al.; Kliesch, S.; Kressin, M.; Savai, R.: On the origin of germ cell neoplasia in situ: Dedifferentiation of human adult Sertoli cells in cross talk with seminoma cells in vitro *. NEOPLASIA 23 (7), pp. 731 - 742 (2021)

Strack, E.; Rolfe, P. A.; Fink, A. F.; Bankov, K.; Schmid, T.; Solbach, C.; Savai, R.; Sha, W.; Pradel, L.; Hartmann, S. et al.; Bruene, B.; Weigert, A.: Identification of tumor-associated macrophage subsets that are associated with breast cancer prognosis. CLINICAL AND TRANSLATIONAL MEDICINE 10 (8), e239 (2020)

Kuester, M. M.; Schneider, M. A.; Richter, A. M.; Richtmann, S.; Winter, H.; Kriegsmann, M.; Pullamsetti, S. S.; Stiewe, T.; Savai, R.; Muley, T. et al.; Dammann, R. H.: Epigenetic Inactivation of the Tumor Suppressor IRX1 Occurs Frequently in Lung Adenocarcinoma and Its Silencing Is Associated with Impaired Prognosis. CANCERS 12 (12), 3528 (2020)

Olesch, C.; Sirait-Fischer, E.; Berkefeld, M.; Fink, A. F.; Susen, R. M.; Ritter, B.; Michels, B. E.; Steinhilber, D.; Greten, F. R.; Savai, R. et al.; Takeda, K.; Bruene, B.; Weigert, A.: S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8(+) T cell expansion. JOURNAL OF CLINICAL INVESTIGATION 130 (10), pp. 5461 - 5476 (2020)

Zheng, X.; Mansouri, S.; Krager, A.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Wheelock, C. E.; Savai, R.: Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment. EUROPEAN RESPIRATORY REVIEW 29 (157), 200134 (2020)

Baig, M. S.; Roy, A.; Rajpoot, S.; Liu, D.; Savai, R.; Banerjee, S.; Kawada, M.; Faisal, S. M.; Saluja, R.; Saqib, U. et al.; Ohishi, T.; Wary, K. K.: Tumor-derived exosomes in the regulation of macrophage polarization. INFLAMMATION RESEARCH 69 (5), pp. 435 - 451 (2020)

El-Nikhely, N.; Karger, A.; Sarode, P.; Singh, I.; Weigert, A.; Wietelmann, A.; Stiewe, T.; Dammann, R.; Fink, L.; Grimminger, F. et al.; Barreto, G.; Seeger, W.; Pullamsetti, S. S.; Rapp, U. R.; Savai, R.: Metastasis-Associated Protein 2 Represses NF-kappa B to Reduce Lung Tumor Growth and Inflammation. CANCER RESEARCH 80 (19), pp. 4199 - 4211 (2020)

Pullamsetti, S. S.; Mamazhakypov, A.; Weissmann, N.; Seeger, W.; Savai, R.: Hypoxia-inducible factor signaling in pulmonary hypertension. JOURNAL OF CLINICAL INVESTIGATION 130 (11), pp. 5638 - 5651 (2020)

Salazar, Y.; Zheng, X.; Brunn, D.; Raifer, H.; Picard, F.; Zhang, Y.; Winter, H.; Guenther, S.; Weigert, A.; Weigmann, B. et al.; Dumoutier, L.; Renauld, J.-C.; Waisman, A.; Schmall, A.; Tufman, A.; Fink, L.; Bruene, B.; Bopp, T.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Huber, M.; Savai, R.: Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer. JOURNAL OF CLINICAL INVESTIGATION 130 (7), pp. 3560 - 3575 (2020)

Sarode, P.; Mansouri, S.; Karger, A.; Schaefer, M. B.; Grimminger, F.; Seeger, W.; Savai, R.: Epithelial cell plasticity defines heterogeneity in lung cancer. CELLULAR SIGNALLING 65, 109463 (2020)