Publications of Rajkumar Savai

Seker-Cin, H.; Tay, T. K. Y.; Kazdal, D.; Kluck, K.; Ball, M.; Neumann, O.; Winter, H.; Herth, F.; Heussel, C.-P.; Savai, R. et al.; Schirmacher, P.; Thomas, M.; Budczies, J.; Allgaeuer, M.; Christopoulos, P.; Stenzinger, A.; Volckmar, A.-L.: Analysis of rare fusions in NSCLC: Genomic architecture and clinical implications. LUNG CANCER 184, 107317 (2023)

Khassafi, F.; Chelladurai, P.; Valasarajan, C.; Nayakanti, S. R.; Martineau, S.; Sommer, N.; Yokokawa, T.; Boucherat, O.; Kamal, A.; Kiely, D. G. et al.; Swift, A. J.; Alabed, S.; Omura, J.; Breuils-Bonnet, S.; Kuenne, C.; Potus, F.; Guenther, S.; Savai, R.; Seeger, W.; Looso, M.; Zaugg, J. B.; Tello, K.; Provencher, S.; Bonnet, S.; Pullamsetti, S. S.: Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension. NATURE CARDIOVASCULAR RESEARCH 2 (10), pp. 917 - + (2023)

Karger, A.; Mansouri, S.; Leisegang , M. S.; Weigert, A.; Guenther, S.; Kuenne, C.; Wittig , I.; Zukunft , S.; Klatt , S.; Aliraj , B. et al.; Klotz V , L.; Winter , H.; Mahavadi, P.; Fleming , I.; Ruppert , C.; Witte , B.; Alkoudmani , I.; Gattenloehner, S.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: ADPGK-AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth. EMBO JOURNAL (2023)

Zheng, X.; Sarode, P.; Weigert , A.; Turkowski, K.; Chelladurai, P.; Guenther, S.; Kuenne, C.; Winter , H.; Stenzinger, A.; Reu, S. et al.; Grimminger, F.; Stiewe, T.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: The HDAC2-SP1 Axis Orchestrates Protumor Macrophage Polarization. CANCER RESEARCH 83 (14), pp. 2345 - 2357 (2023)

Goldschmid, H.; Kluck, K.; Ball, M.; Kirchner, M.; Allgaeuer, M.; Winter, H.; Herth, F.; Heussel, C.-P.; Pullamsetti, S. S.; Savai, R. et al.; Yong, T. T. K.; Schirmacher, P.; Peters, S.; Thomas, M.; Christopoulos, P.; Budczies, J.; Stenzinger, A.; Kazdal, D.: Spatial profiling of the microenvironment reveals low intratumoral heterogeneity and STK11-associated immune evasion in therapy-naive lung adenocarcinomas. LUNG CANCER 180, 107212 (2023)

Nayakanti, S. R.; Friedrich, A.; Sarode, P.; Jafari, L.; Maroli, G.; Boehm, M.; Bourgeois, A.; Grobs, Y.; Khassafi, F.; Kuenne, C. et al.; Guenther, S.; Dabral, S.; Wilhelm, J.; Weiss, A.; Wietelmann, A.; Kojonazarov, B.; Janssen, W.; Looso, M.; de Man, F.; Provencher, S.; Tello, K.; Seeger, W.; Bonnet, S.; Savai, R.; Schermuly, R.; Pullamsetti, S. S.: Targeting Wnt-ss-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling. CIRCULATION RESEARCH 132 (11), pp. 1468 - 1485 (2023)

Lutz, V.; Hellmund, V. M.; Picard, F. S. R.; Raifer, H.; Ruckenbrod, T.; Klein, M.; Bopp, T.; Savai, R.; Duewell, P.; Keber, C. U. et al.; Weigert, A.; Chung, H.-R.; Buchholz, M.; Menke, A.; Gress, T. M.; Huber, M.; Bauer, C.: IL18 Receptor Signaling Regulates Tumor-Reactive CD8(+) T-cell Exhaustion via Activation of the IL2/STAT5/mTOR Pathway in a Pancreatic Cancer Model. CANCER IMMUNOLOGY RESEARCH 11 (4), pp. 421 - 434 (2023)

Spella, M.; Ntaliarda, G.; Skiadas, G.; Lamort, A.-S.; Vreka, M.; Marazioti, A.; Lilis, I.; Bouloukou, E.; Giotopoulou, G. A. A.; Pepe, M. A. A. et al.; Weiss, S. A. I.; Petrera, A.; Hauck, S. M. M.; Koch, I.; Lindner, M.; Hatz, R. A. A.; Behr, J.; Arendt, K. A. M.; Giopanou, I.; Brunn, D.; Savai, R.; Jenne, D. E. E.; de Chateau, M.; Yull, F. E. E.; Blackwell, T. S. S.; Stathopoulos, G. T. T.: Non-Oncogene Addiction of KRAS-Mutant Cancers to IL-1 beta via Versican and Mononuclear IKK beta. CANCERS 15 (6), 1866 (2023)

Picard, F. S. R.; Lutz, V.; Brichkina, A.; Neuhaus, F.; Ruckenbrod, T.; Hupfer, A.; Raifer, H.; Klein, M.; Bopp, T.; Pfefferle, P. I. et al.; Savai, R.; Prinz, I.; Waisman, A.; Moos, S.; Chang, H.-D.; Heinrich, S.; Bartsch, D. K.; Buchholz, M.; Singh, S.; Tu, M.; Klein, L.; Bauer, C.; Liefke, R.; Burchert, A.; Chung, H.-R.; Mayer, P.; Gress, T. M.; Lauth, M.; Gaida, M.; Huber, M.: IL-17A-producing CD8(+) T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts. GUT (2023)

Weigert, A.; Zheng, X.; Nenzel, A.; Turkowski, K.; Guenther, S.; Strack, E.; Sirait-Fischer, E.; Elwakeel, E.; Kur, I. M.; Nikam, V. S. et al.; Valasarajan, C.; Winter, H.; Wissgott, A.; Voswinkel, R.; Grimminger, F.; Brune, B.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system. NATURE COMMUNICATIONS 13 (1), 6078 (2022)

Merle, N.; Elmshaeuser, S.; Strassheimer, F.; Wanzel, M.; Koenig, A. M.; Funk, J.; Neumann, M.; Kochhan, K.; Helmprobst, F.; Pagenstecher, A. et al.; Nist, A.; Mernberger, M.; Schneider, A.; Braun, T.; Borggrefe, T.; Savai, R.; Timofeev, O.; Stiewe, T.: Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase. MOLECULAR CANCER 21 (1), 191 (2022)

Baig, M. S.; Rajpoot, S.; Ohishi, T.; Savai, R.; Seidel, S.; Kamennaya, N. A.; Bezsonov, E. E.; Orekhov, A. N.; Mahajan, P.; Solanki, K. et al.; Saqib, U.: Anti-lung cancer properties of cyanobacterial bioactive compounds. ARCHIVES OF MICROBIOLOGY 204 (10), 603 (2022)

Medrano-Garcia, S.; Morales-Cano, D.; Barreira, B.; Vera-Zambrano, A.; Kumar, R.; Kosanovic, D.; Schermuly, R. T.; Graham, B. B.; Perez-Vizcaino, F.; Mathie, A. et al.; Savai, R.; Pullamseti, S.; Butrous, G.; Fernandez-Malave, E.; Cogolludo, A.: HIV and Schistosoma Co-Exposure Leads to Exacerbated Pulmonary Endothelial Remodeling and Dysfunction Associated with Altered Cytokine Landscape. CELLS 11 (15), 2414 (2022)

Sommer, N.; Theine, F. F.; Pak, O.; Tello, K.; Richter, M.; Gall, H.; Wilhelm, J.; Savai, R.; Weissmann, N.; Seeger, W. et al.; Ghofrani, H. A.; Hecker, M.: Mitochondrial Respiration in Peripheral Blood Mononuclear Cells Negatively Correlates with Disease Severity in Pulmonary Arterial Hypertension. JOURNAL OF CLINICAL MEDICINE 11 (14), 4132 (2022)

Kuhnert, S.; Mansouri, S.; Rieger, M. A.; Savai, R.; Avci, E.; Diaz-Pina, G.; Padmasekar, M.; Looso, M.; Hadzic, S.; Acker, T. et al.; Klatt, S.; Wilhelm, J.; Fleming, I.; Sommer, N.; Weissmann, N.; Vogelmeier, C.; Bals, R.; Zeiher, A.; Dimmeler, S.; Seeger, W.; Pullamsetti, S. S.: Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD. CELLS 11 (13), 2121 (2022)

Chelladurai, P.; Kuenne, C.; Bourgeois, A.; Guenther, S.; Valasarajan, C.; Cherian V, A.; Rottier, R. J.; Romanet, C.; Weigert, A.; Boucherat, O. et al.; Eichstaedt, C. A.; Ruppert, C.; Guenther, A.; Braun, T.; Looso, M.; Savai, R.; Seeger, W.; Bauer, U.-M.; Bonnet, S.; Pullamsetti, S. S.: Epigenetic reactivation of transcriptional programs orchestrating fetal lung development in human pulmonary hypertension. SCIENCE TRANSLATIONAL MEDICINE 14 (648), eabe5407 (2022)

Kandra, P.; Nandigama, R.; Eul, B.; Huber, M.; Kobold, S.; Seeger, W.; Grimminger, F.; Savai, R.: Utility and Drawbacks of Chimeric Antigen Receptor T Cell (CAR-T) Therapy in Lung Cancer. FRONTIERS IN IMMUNOLOGY 13, 903562 (2022)

Sekar, D.; Dillmann, C.; Sirait-Fischer, E.; Fink, A. F.; Zivkovic, A.; Baum, N.; Strack, E.; Klatt, S.; Zukunft, S.; Wallner, S. et al.; Descot, A.; Olesch, C.; da Silva, P.; von Knethen, A.; Schmid, T.; Groesch, S.; Savai, R.; Ferreiros, N.; Fleming, I.; Ghosh, S.; Rothlin V, C.; Stark, H.; Medyouf, H.; Bruene, B.; Weigert, A.: Phosphatidylserine Synthase PTDSS1 Shapes the Tumor Lipidome to Maintain Tumor-Promoting Inflammation. CANCER RESEARCH 82 (8), pp. 1617 - 1632 (2022)

Elwakeel, E.; Brueggemann, M.; Wagih, J.; Lityagina, O.; Elewa, M. A. F.; Han, Y.; Froemel, T.; Popp, R.; Nicolas, A. M.; Schreiber, Y. et al.; Gradhand, E.; Thomas, D.; Nuesing, R.; Steinmetz-Spaeh, J.; Savai, R.; Fokas, E.; Fleming, I.; Greten, F. R.; Zarnack, K.; Bruene, B.; Weigert, A.: Disruption of Prostaglandin E2 Signaling in Cancer-Associated Fibroblasts Limits Mammary Carcinoma Growth but Promotes Metastasis. CANCER RESEARCH 82 (7), pp. 1380 - 1395 (2022)

Gredic, M.; Wu, C.-Y.; Hadzic, S.; Pak, O.; Savai, R.; Kojonazarov, B.; Doswada, S.; Weiss, A.; Weigert, A.; Guenther, A. et al.; Brandes, R. P.; Schermuly, R. T.; Grimminger, F.; Seeger, W.; Sommer, N.; Kraut, S.; Weissmann, N.: Myeloid-cell-specific deletion of inducible nitric oxide synthase protects against smoke-induced pulmonary hypertension in mice. EUROPEAN RESPIRATORY JOURNAL 59 (4), 2101153 (2022)