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Institute
Cardiac Development and Remodelling (Dept. I)
Pharmacology (Dept. II)
Developmental Genetics (Dept. III)
Cellular Resilience
Circadian regulation of Cardiometabolism
Neurocardiac Axis
Epigenetics

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Max Planck Institute for Heart and Lung Research - W. G. Kerckhoff Institute

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Beyond Mendel: Researchers call for a new understanding of genetics

Publications of Ai Kawamura

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Journal Article (1)

Journal Article (1)

2019

Journal Article

Kawamura, A.; Kawamura, T.; Riddell, M.; Hikita, T.; Yanagi, T.; Umemura, H.; Nakayama, M.: Regulation of programmed cell death ligand 1 expression by atypical protein kinase C lambda/iota in cutaneous angiosarcoma. CANCER SCIENCE 110 (5), pp. 1780 - 1789 (2019)

MPG.PuRe

DOI

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Prof. Dr. Didier Stainier

Managing Director +49 6032 705-1302 +49 6032 705-1304 didier.stainier@...

Original Publication

Tautz et al.

Beyond Mendel: a call to revisit the genotype–phenotype map through new experimental paradigms

Genetics, iyag024

Source

DOI

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Declining NAD⁺ levels in the aging heart weaken circadian rhythm and cardiac health

Laser confocal microscope image of a ‘sleeping’ tumour cell (green) in the vicinity of a blood vessel (red/blue).

Protein in blood vessels puts tumour cells into deep sleep

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Membrane protein PEAR1 prevents the development of metastases

Full muscle power only with TAF4A: If the transcription factor is active in muscle stem cells, the cell nuclei are intact (top left), while the absence of TAF4A results in unstable cell nuclei (top right). As a result, the regenerative capacity of muscles (bottom row) without TAF4A (right) is severely impaired. In comparison, the muscle cells in the tissue section of control animals with TAF4A appear regular and intact.

How muscle stem cells keep their nucleus intact to maintain regenerative power

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Transcription factor TAF4A preserves nuclei in muscle stem cells and initiates muscle regeneration after injury

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Protein switch in blood vessels exacerbates damage in vascular diseases

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Digital image of the heart in a human chest

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ERC Proof of Concept Grant Awarded to Max Planck Team for RNA-Based Therapy Targeting Duchenne Muscular Dystrophy

July 14, 2025

A team of researchers at the Max Planck Institute for Heart and Lung Research, led by Prof. Dr. Didier Y.R. Stainier, has been awarded a prestigious ERC Proof of Concept (PoC) grant to advance a groundbreaking RNA-based therapeutic strategy for Duchenne Muscular Dystrophy (DMD).