Publications of Werner Seeger

Neogi, U.; Ambikan, A. T.; Turkowski, K.; Schneider, M. A.; Beutgen, V. M.; Graumann, J.; Winter, H.; Bartkuhn, M.; Seeger, W.; Pullamsetti, S. S. et al.; Savai, R.: Plasma proteomic profiling and molecular clustering reveal immune-defined prognostic subtypes in lung adenocarcinoma. INTERNATIONAL JOURNAL OF CANCER (2025)

Mansouri, S.; Karger, A.; Ruppert, C.; Schneider, M. A.; Weigert, A.; Nandigama, R.; Aliraj, B.; Strotmann, L.; Cherian, A. V.; Pruefer, D. et al.; Dorfmuller, P.; Fink, L.; Alkoudmani, I.; Gattenlohner, S.; Eul, B.; Althoff, A.; Kleine, P.; Winter, H.; Guenther, A.; Ghofrani, H.-A.; Pullamsetti, S. S.; Grimminger, F.; Seeger, W.; Savai, R.: Living human lung slices for ex vivo modelling of lung cancer. JCI INSIGHT 10 (17), e190703 (2025)

Rako, Z. A.; Cekay, M.; Yogeswaran, A.; Yildiz, S.; Arndt, P. F.; Kremer, N.; Schaefer, S.; Janetzko, P.; Thal, B. R.; Mummert, C. M. et al.; Franken, J. K.; Soethe, H.; Werner, H. F.; Dumitrascu, R.; Grimminger, F.; Ghofrani, H. A.; Pullamsetti, S. S.; Seeger, W.; Naeije, R.; Savai, R.; Eul, B.; Tello, K.: Echocardiographic Measure of Right Ventricular-Pulmonary Arterial Coupling Predicts Survival in Lung Cancer. ANNALS OF THE AMERICAN THORACIC SOCIETY 22 (7), pp. 1071 - 1078 (2025)

Jafari, L.; Wiedenroth, C. B.; Kriechbaum, S. D.; Gruen, D.; Chelladurai, P.; Guenther, S.; Kuenne, C.; Spaeth, A. M.; Cherian, A. V.; Troidl, C. et al.; Wilhelm, J.; Keranov, S.; Keller, T.; Kojonazarov, B.; Schermuly, R. T.; Guth, S.; Doerr, O.; Nef, H.; Boehm, M.; Spiekerkoetter, E.; Leszek, P.; Varga, Z. V.; Ferdinandy, P.; Ghofrani, H. A.; Dorfmueller, P.; Weissmann, N.; Hamm, C. W.; Mayer, E.; Seeger, W.; Liebetrau, C.; Pullamsetti, S. S.: Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension govern right ventricle remodeling and recovery. NATURE CARDIOVASCULAR RESEARCH 4 (7) (2025)

Khadim, A.; Kiliaris, G.; Vazquez-Armendariz, A. I.; Procida-Kowalski, T.; Glaser, D.; Bartkuhn, M.; Malik, T.; Chu, X.; Moiseenko, A.; Kuznetsova, I. et al.; Ahmadvand, N.; Lingampally, A.; Hadzic, S.; Alexopoulos, I.; Chen, Y.; Gueunther, A.; Behr, J.; Neumann, J.; Schiller, H. B.; Li, X.; Weissmann, N.; Braun, T.; Seeger, W.; Wygrecka, M.; Morty, R. E.; Herold, S.; El Agha, E.: Myofibroblasts emerge during alveolar regeneration following influenza-virus-induced lung injury. CELL REPORTS 44 (2), 115248 (2025)

Lingampally, A.; Truchi, M.; Mauduit, O.; Delcroix, V.; Vasquez-Pacheco, E.; Gautier-Isola, M.; Chu, X.; Khadim, A.; Chao, C.-M.; Zabihi, M. et al.; Taghizadeh, S.; Rivetti, S.; Marega, M.; Moiseenko, A.; Hadzic, S.; Vazquez-Armendariz, A. I.; Herold, S.; Guenther, S.; Millar-Buechner, P.; Koepke, J.; Samakovlis, C.; Wilhelm, J.; Bartkuhn, M.; Braun, T.; Weissmann, N.; Zhang, J.; Wygrecka, M.; Makarenkova, H. P.; Guenther, A.; Seeger, W.; Chen, C.; El Agha, E.; Mari, B.; Bellusci, S.: Evidence for a lipofibroblast-to-Cthrc1+ myofibroblast reversible switch during the development and resolution of lung fibrosis in young mice. EUROPEAN RESPIRATORY JOURNAL 65 (2), 2300482 (2025)

Seidel, L.-M.; Thudium, J.; Smith, C.; Sapehia, V.; Sommer, N.; Wujak, M.; Weissmann, N.; Seeger, W.; Schermuly, R. T.; Novoyatleva, T.: Death-associated protein kinase 1 prevents hypoxia-induced metabolic shift and pulmonary arterial smooth muscle cell proliferation in PAH. CELLULAR SIGNALLING 127, 111527 (2024)

Seidel, L.-M.; Thudium, J.; Smith, C.; Sapehia, V.; Sommer, N.; Wujak, M.; Weissmann, N.; Seeger, W.; Schermuly, R. T.; Novoyatleva, T.: Death-associated protein kinase 1 prevents hypoxia-induced metabolic shift and pulmonary arterial smooth muscle cell proliferation in PAH. CELLULAR SIGNALLING 127, 111527 (2024)

Kuhnert, S.; Sommerlad, J.; Gall, H.; Weder, M. M.; Wolff, M.; Eberle, S.; Sander, M.; Reichert, M.; Koch, C.; Askevold, I. et al.; Hecker, A.; Padberg, W.; Ostermann, M.; Mehta, R.; Ronco, C.; Birk, H.-W.; Seeger, W.; Mayer, K.; Hecker, M.; Husain-Syed, F.: Postoperative Fluid Accumulation is Associated With Underestimation of AKI Severity in Lung Transplant Recipients. CLINICAL TRANSPLANTATION 38 (9), e15457 (2024)

Cekay, M.; Arndt, P. F.; Franken, J. K.; Wilhelm, J.; Pullamsetti, S. S.; Roller, F. C.; Sommer, N.; Askevold, I.; Luedecke, G.; Langer, C. et al.; Stein, M.; Zeppernick, F.; Tello, K.; Sibelius, U.; Grimminger, F.; Seeger, W.; Savai, R.; Eul, B.: Non-invasive surrogate markers of pulmonary hypertension are associated with poor survival in patients with cancer. BMJ OPEN RESPIRATORY RESEARCH 11 (1), e001916 (2024)

Schlueter, B. C.; Quanz, K.; Baldauf, J.; Petrovic, A.; Ruppert, C.; Guenther, A.; Gall, H.; Tello, K.; Grimminger, F.; Ghofrani, H. -. et al.; Weissmann, N.; Seeger, W.; Schermuly, R. T.; Weiss, A.: The diverging roles of insulin-like growth factor binding proteins in pulmonary arterial hypertension. VASCULAR PHARMACOLOGY 155, 107379 (2024)

Turkowski, K.; Herzberg, F.; Guenther, S.; Weigert, A.; Haselbauer, T.; Fink, L.; Brunn, D.; Grimminger, F.; Seeger, W.; Sueltmann, H. et al.; Stiewe, T.; Pullamsetti, S. S.; Savai, R.: miR-147b mediated suppression of DUSP8 promotes lung cancer progression. ONCOGENE (2024)

Palumbo, F.; Gunjak, M.; Lee, P. J.; Guenther, S.; Hilgendorff, A.; Vadasz, I.; Herold, S.; Seeger, W.; Muehlfeld, C.; Morty, R. E.: Impact of different tissue dissociation protocols on endothelial cell recovery from developing mouse lungs. CYTOMETRY PART A (2024)

Hirani, D. V.; Thielen, F.; Mansouri, S.; Danopoulos, S.; Vohlen, C.; Haznedar-Karakaya, P.; Mohr, J.; Wilke, R.; Selle, J.; Grosch, T. et al.; Mizik, I.; Odenthal, M.; Alvira, C. M.; Kuiper-Makris, C.; Pryhuber, G. S.; Pallasch, C.; van Koningsbruggen-Rietschel, S.; Al-Alam, D.; Seeger, W.; Savai, R.; Doetsch, J.; Alcazar, M. A. A.: CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia. INFLAMMATION AND REGENERATION 43 (1), 52 (2023)

Khassafi, F.; Chelladurai, P.; Valasarajan, C.; Nayakanti, S. R.; Martineau, S.; Sommer, N.; Yokokawa, T.; Boucherat, O.; Kamal, A.; Kiely, D. G. et al.; Swift, A. J.; Alabed, S.; Omura, J.; Breuils-Bonnet, S.; Kuenne, C.; Potus, F.; Guenther, S.; Savai, R.; Seeger, W.; Looso, M.; Zaugg, J. B.; Tello, K.; Provencher, S.; Bonnet, S.; Pullamsetti, S. S.: Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension. NATURE CARDIOVASCULAR RESEARCH 2 (10), pp. 917 - + (2023)

Karger, A.; Mansouri, S.; Leisegang , M. S.; Weigert, A.; Guenther, S.; Kuenne, C.; Wittig , I.; Zukunft , S.; Klatt , S.; Aliraj , B. et al.; Klotz V , L.; Winter , H.; Mahavadi, P.; Fleming , I.; Ruppert , C.; Witte , B.; Alkoudmani , I.; Gattenloehner, S.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: ADPGK-AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth. EMBO JOURNAL (2023)

Alberro-Brage , A.; Kryvenko , V.; Malainou , C.; Guenther, S.; Morty, R. E.; Seeger, W.; Herold, S.; Samakovlis, C.; Vadasz, I.: Influenza virus decreases albumin uptake and megalin expression in alveolar epithelial cells. FRONTIERS IN IMMUNOLOGY 14, 1260973 (2023)

Bandorski, D.; Tello, K.; Erdal, H.; Sommerlad, J.; Wilhelm, J.; Vadasz, I.; Hecker, M.; Walmrath, D.; Seeger, W.; Krauss, E. et al.; Kuhnert, S.: Clinical Utility of Pepsin and Bile Acid in Tracheal Secretions for Accurate Diagnosis of Aspiration in ICU Patients. JOURNAL OF CLINICAL MEDICINE 12 (17), 5466 (2023)

Zheng, X.; Sarode, P.; Weigert , A.; Turkowski, K.; Chelladurai, P.; Guenther, S.; Kuenne, C.; Winter , H.; Stenzinger, A.; Reu, S. et al.; Grimminger, F.; Stiewe, T.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: The HDAC2-SP1 Axis Orchestrates Protumor Macrophage Polarization. CANCER RESEARCH 83 (14), pp. 2345 - 2357 (2023)

Steinbeis , F.; Thibeault , C.; Steinbrecher, S.; Ahlgrimm, Y.; Haack, I. A.; August, D.; Balzuweit, B.; Bellinghausen, C.; Berger, S.; Chaplinskaya-Sobol, I. et al.; Cornely, O.; Doeblin, P.; Endres, M.; Fink, C.; Finke, C.; Frank, S.; Hanss, S.; Hartung, T.; Hellmuth, J. C.; Herold, S.; Heuschmann, P.; Heyckendorf, J.; Heyder, R.; Hippenstiel, S.; Hoffmann, W.; Kelle, S. U.; Knape, P.; Koehler, P.; Kretzler, L.; Leistner, D. M.; Lienau, J.; Lorbeer, R.; Lorenz-Depiereux, B.; Luettke, C. D.; Mai, K.; Merle, U.; Meyer-Arndt, L. A.; Miljukov, O.; Muenchhoff, M.; Mueller-Plathe, M.; Neuhann, J.; Neuhauser, H.; Nieters, A.; Otte, C.; Pape, D.; Pinto, R. M.; Pley, C.; Pudszuhn, A.; Reuken, P.; Rieg, S.; Ritter, P.; Rohde, G.; Roennefarth, M.; Ruzicka, M.; Schaller, J.; Schmidt, A.; Schmidt, S.; Schwachmeyer, V.; Schwanitz, G.; Seeger, W.; Stahl, D.; Stobaeus, N.; Stubbe, H. C.; Suttorp, N.; Temmesfeld, B.; Thun, S.; Triller, P.; Trinkmann, F.; Vadasz, I.; Valentin, H.; Vehreschild, M.; von Kalle, C.; von Lilienfeld-Toal, M.; Weber, J.; Welte, T.; Wildberg, C.; Wizimirski, R.; Zvork, S.; Sander, L. E.; Vehreschild, J.; Zoller, T.; Kurth, F.; Witzenrath, M.: Analysis of acute COVID-19 including chronic morbidity: protocol for the deep phenotyping National Pandemic Cohort Network in Germany (NAPKON-HAP). INFECTION (2023)