Publications

Wittig, J.; Xu, R.; Lagos, F. D.; Drekolia, M.-K.; Zhang, B.; Theodorou, I.; Chen, Y.; Du, Y.; Gupta, L.; Hanyu, C. et al.; Yuanyuan, L.; Bo, C.; Gunther, S.; Wittig, I.; Ola, R.; Hu, J.; Bibli, S.-I.: Persulfidation alters gene regulatory programs and promotes endothelial specification. REDOX BIOLOGY 89, 103926 (2026)

Malacarne, P. F.; Lopez, M.; Chatterjee, S.; Herrle, N.; Weiss, L.; Gunther, S.; Osborne, T.; Glaubitz, C.; Schmid, T.; Kurrle, N. et al.; Schnutgen, F.; Lutjohann, D.; Brandes, R. P.; Rezende, F.: Endothelial cytochrome P450-derived cholesterol limits angiogenesis. REDOX BIOLOGY 95, 104289 (2026)

Wang, L.; Staps, M.; Gunther, S.; El Agha, E.; Bellusci, S.; Kuenne, C.; Du, J.; Schneider, A.; Braun, T.: Cell Type-Specific Targeting of Different Smooth Muscle Cell Populations by Intersectional Genetics. CIRCULATION 154 (6), pp. 565 - 583 (2026)

Kwon, J.; Persechino, M.; Shao, J.; Shamsara, J.; Spitznagel, B.; Salwig, I.; Sanda, M.; Offermanns, S.; Kolb, P.; Wettschureck, N.: Small molecule inhibitor of orphan GPCR dimerization improves host defense and blood pressure control in mice. JOURNAL OF CLINICAL INVESTIGATION 136 (15), e203162 (2026)

Hofmann, T.; Hettrich, S.; Idrissou, B. M. G.; Waechter, C.; Weiss, M.; Hachim, S.; Kreher, S.; Staps, M.; Canes Esteve, L.; Pankuweit, S. et al.; Milting, H.; Looso, M.; Marty, I.; Engelhardt, S.; Braun, T.; Boettger, T.: Trdn-as directs m6A-dependent transcriptional termination for accurate triadin isoform switching, preventing aberrant dyads and cardiomyopathy cardiomyopathy. NATURE COMMUNICATIONS 17 (1), 7269 (2026)

Elbassioni, A. A. M.; Raheem, A. A.; Song, J.; Johnston, A. S.; Trivett, C.; Lin, H.; Zhang, H.; Bradley, A.; Higgins, E.; Thomson, C. R. et al.; Mooney, L.; Koay, Y. C.; O'Toole, D.; Herzyk, P.; Nixon, C.; Blyth, K.; Hughes, M.; Al-Attar, N.; O'Sullivan, J. F.; Lang, N. N.; Berry, C.; Braun, T.; Schiattarella, G. G.; Giacca, M.; McBride, M. W.; Nicklin, S. A.; Cameron, E. R.; Loughrey, C. M.; MacDonald, E. A.: Targeting RUNX1 protects against diastolic dysfunction in a two-hit mouse model of heart failure with preserved ejection fraction. CARDIOVASCULAR RESEARCH 122 (10), pp. 1318 - 1328 (2026)

Mansouri, S.; Hesami, G.; Ambikan, A.; Karger, A.; Klatt, S.; Neogi, U.; Kurakula, K. B.; Aliraj, B.; Miller, A.; Petrova, B. et al.; Sanda, M.; Sirait-Fischer, E.; Guenther, S.; Kuenne, C.; Ruppert, C.; Alkoudmani, I.; Gattenlohner, S.; Zukunft, S.; Fleming, I.; Haschemi, A.; Stiewe, T.; Grimminger, F.; Reck, M.; Weigert, A.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: IRG1/itaconate rewires macrophage and lung tumor metabolism through G6PD inhibition. CELL METABOLISM 38 (7), pp. 1460 - 1477 (2026)

Lam, F.; Warwick, T.; Oo, J. A.; Kruger, A. Y.; Kreis, N.-N.; Diagel, A.; Ponce, J. I.; Tirunagari, P.; Bayer, M. E.; Nonn, O. et al.; Dechend, R.; Walther, T.; Boon, R. A.; Baker, A. H.; Gunther, S.; Wittig, I.; Chen, Z.; Muller-McNicoll, M.; Louwen, F.; Brandes, R. P.; Leisegang, M. S.: LINC00607 facilitates endothelial VEGF-A receptor FLT1 splicing. MOLECULAR THERAPY 34 (7), pp. 4323 - 4338 (2026)

Shiva, N.; Kawase, H.; Einsiedel, J.; Kwon, J.; Kumar, S.; Shao, J.; Du, Z.; Kubin, N.; Shimari, M.; Gunther, S. et al.; Li, T.; Dierickx, P.; Sossalla, S.; Offermanns, S.; Gmeiner, P.; Wettschureck, N.: Neurotensin receptor 2 agonism attenuates adverse cardiac remodeling in preclinical models. SCIENCE TRANSLATIONAL MEDICINE 18 (856), eaea9877 (2026)

Raheja, M.; Guven, B.; Szymanski, W.; Gunther, S.; Kuenne, C.; Rakultsev, V.; Segarra, M.; Bozkurt, S.; Munch, C.; Kaulich, M. et al.; Graumann, J.; Fleming, I.; Siragusa, M.: A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces cell cycle arrest and senescence. CELL COMMUNICATION AND SIGNALING 24 (1), 372 (2026)

Espinosa-Alcantud, M.; Sima, N.; Fernandez-Duran, I.; Marazuela-Duque, A.; Martinez-Cebrian, G.; Guitart-Solanes, A.; Gamez-Garcia, A.; Martinez-Redondo, P.; Bosch-Presegue, L.; Vazquez, B. N. et al.; Panos, L.; Bech, J. J.; Thomas, T.; Martinez-Balbas, M. A.; Voss, A. K.; Kruger, M.; Serrano, L.; Olivella, M.; Cuartero, S.; de la Torre, C.; Vaquero, A.: SIRT2 antagonizes MOF function during mitotic entry. SCIENCE ADVANCES 12 (25), eaeb2915 (2026)

Candlish, M.; Hofmann, J.; Brosamle, D.; Haessler, A.; DeMeglio, M.; Skodras, A.; Tushev, G.; De Biasi, E. S.; Gunther, S.; Wiegandt, R. et al.; Theis, H.; De Domenico, E.; Hermann, N. S.; Breunig, P.; Sauerland, C.; Nilsson, K. P. R.; Beyer, M. D.; Looso, M.; Windbergs, M.; Roeber, S.; Herms, J.; Neher, J. J.; Chiocchetti, A. G.; Hefendehl, J. K.: Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology. JOURNAL OF NEUROINFLAMMATION 23 (1), 213 (2026)

Liang, Z.; Long, X.; Xiong, Z.; Wong, P. P.-C.; Huang, S.; Chen, S.; Zhang, Y.; Zhang, L.; Leung, C.; Cao, J. et al.; Wu, H.; Yue, H.; Zhao, Z.; Tu, Y.; Yin, B.; Yang, W.; Wang, J.; Chen, S.; Zhang, X.; Tsang, Y. W.; Zhong, C.; Liu, X.; Ding, L.; Lu, J.; Si-Tou, W. W.-Y.; Liu, Y.; Wang, Y.; Lin, Y.; Liang, J.; Ren, W.; Vong, J. S.-L.; Tong, M.; Tian, X.; Hui, H. X.; Zhou, J.; Ngai, S.; Ni, S.; To, K.-F.; Braun, T.; Sung, J. J.-Y.; Chan, S. L.; Cheng, A. S.-L.: Tumor cells metabolically resist immune-checkpoint therapy by macrophage efferocytosis-mediated fatty acid recycling. CANCER CELL 44 (6), pp. 1235 - 1254 (2026)

Yeganeh, M.; Najar-Asl, M.; Karamzadeh, R.; Nemati, S.; Yakhkeshi, S.; Akhlaghpour, A.; Guenther, S.; Naderi, S.; Shahbazi, E.; Mollamohammadi, S. et al.; Simorgh, S.; Hassani, S.-N.; Shojaei, A.; Mirnajafizadeh, J.; Abolghasemi Dehaqani, M.-R.; Ahmadabadi, M. N.; Huang, R.; Shahpasand, K.; Hisanaga, S.-I.; Braun, T.; Baharvand, H.: Human pluripotent stem cell-derived neuroepithelial cells develop into an organizer for optic tectum formation in the chicken diencephalon. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 14, 1812038 (2026)

Siragusa, M.; Graumann, J.; Kuenne, C.; Gunther, S.; Jeratsch, S.; Guven, B.; Susser, S.; Talyan, S.; Bezuneh, B.; Matthess, Y. et al.; Cartura, M.; Zhou, X.; Cho, H.; Sachs, N.; Maegdefessel, L.; Muller, O. J.; Troidl, C.; Nef, H. M.; Looso, M.; Kaulich, M.; Offermanns, S.; Fleming, I.: Identification of unannotated microproteins involved in endothelial cell homeostasis, dysfunction, and vascular disease. CARDIOVASCULAR RESEARCH (2026)

Kawase, H.; Liu, S.; Kurz, S.; Bengelsdorff, V.; Bonnavion, R.; Jin, Y.-J.; Roquid, K. A.; Cho, H.; Liang, G.; Banicevic, M. et al.; Shiva, N.; Yunes-Leites, P. S.; Gunther, S.; Tombor, L.; Dimmeler, S.; Looso, M.; Mattonet, K.; Wettschureck, N.; Muller, U. C.; Offermanns, S.: Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis. SCIENCE ADVANCES 12 (21), eaeh0301 (2026)

Wang, J.; Li, J.; Chin, A. W. H.; Luo, B.; Wei, J.; Qiu, J.; Ren, J.; Xia, Y.; Braun, T.; Poon, L. L. M. et al.; Feng, B.: Redirection of SARS-CoV-2 to phagocytes by intranasal sACE2-Fc as a universal decoy confers complete prophylactic protection. ELIFE 14, RP108883 (2026)

Kubin, N.; Gajawada, P.; Kortl, T.; Schneider, A.; Han, L.; Zelarayan, L. C.; Braun, T.; Sossalla, S.; Choi, Y.-H.; Richter, M.: Coordinated Developmental Remodeling of IGF/FGF-MAPK Signaling and Cytoskeletal Plasticity Coincides with the Loss of Cardiac Regenerative Capacity. CELLS 15 (10), 873 (2026)

Tarasco, M.; Juan, T.; Alayoubi, Y.; Kulkarni, R.; Schumann, A.; da Silva, A. R.; Albu, M.; Dwari, M.; Dlnija, M.; Gunther, S. et al.; Looso, M.; Stainier, D. Y. R.: Time-resolved single-cell transcriptomics maps zebrafish heart development. CELL REPORTS 45 (4), 117249 (2026)

Torigata, K.; Matsuura, R.; Nagatomo, F.; Thiha, M.; Hikita, T.; Iseoka, H.; Takagi, H.; Koshimizu, U.; Sakakima, H.; Izumi, S. et al.; Hatano, A.; Braun, T.; Sawa, Y.; Miyagawa, S.; Nakayama, M.: Human iPSC cardiomyocyte patch transplantation modifies extracellular matrix and fibroblast behavior after myocardial infarction. ISCIENCE 29 (4), 115341 (2026)