Publications

Panza, P.; Kim, H.-T.; Lautenschlaeger, T.; Piesker, J.; Guenther, S.; Alayoubi, Y.; Cleaver, O.; Looso, M.; Stainier, D. Y. R.: The lung microvasculature promotes alveolar type 2 cell differentiation via secreted SPARCL1. STEM CELL REPORTS 20 (4), 102451 (2025)

Ianni, A.; Vaquero, A.; Braun, T.: Fibroblastic niches in action: CCL19⁺ reticular cells drive anti-tumor immunity in lung cancer. SIGNAL TRANSDUCTION AND TARGETED THERAPY 10 (1), 96 (2025)

Manickam, N.; Sultan, I.; Panthel, J.; Kujundzic, H.; Fischer, A.; Schmitz, K.; Jurado, M. R.; Morales, D. R.; John, D.; Glaser, S.-F. et al.; Stilz, K. A.; Malacarne, P. F.; Brandes, R. P.; Braun, T.; Lerchenmueller, C.; Betge, F.; Abplanalp, W. T.; Alitalo, K.; Dimmeler, S.; Wagner, J. U. G.: Beneficial effects of vascular endothelial growth factor B gene transfer in the aged heart. CARDIOVASCULAR RESEARCH (2025)

Falcucci, L.; Dooley, C. M.; Adamoski, D.; Juan, T.; Martinez, J.; Georgieva, A. M.; Mamchaoui, K.; Cirzi, C.; Stainier, D. Y. R.: Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy. NATURE (639(8054)), pp. 493 - 502 (2025)

Khadim, A.; Kiliaris, G.; Vazquez-Armendariz, A. I.; Procida-Kowalski, T.; Glaser, D.; Bartkuhn, M.; Malik, T.; Chu, X.; Moiseenko, A.; Kuznetsova, I. et al.; Ahmadvand, N.; Lingampally, A.; Hadzic, S.; Alexopoulos, I.; Chen, Y.; Gueunther, A.; Behr, J.; Neumann, J.; Schiller, H. B.; Li, X.; Weissmann, N.; Braun, T.; Seeger, W.; Wygrecka, M.; Morty, R. E.; Herold, S.; El Agha, E.: Myofibroblasts emerge during alveolar regeneration following influenza-virus-induced lung injury. CELL REPORTS 44 (2), 115248 (2025)

Gupta, S.; Bajwa, G. K.; El-Sammak, H.; Mattonet, K.; Guenther, S.; Looso, M.; Stainier, D. Y. R.; Marin-Juez, R.: The transmembrane glycoprotein Gpnmb is required for the immune and fibrotic responses during zebrafish heart regeneration. DEVELOPMENTAL BIOLOGY 521, pp. 153 - 162 (2025)

Kwon, J.; Haruya, K.; Mattonet, K.; Guenther, S.; Hahnefeld, L.; Shamsara, J.; Heering, J.; Kurz, M.; Kirchhofer, S.; Krasel, C. et al.; Ulrich, M.; Persechino, M.; Murthy, S.; Orlandi, C.; Sadik, C. D.; Geisslinger, G.; Buenemann, M.; Kolb, P.; Offermanns, S.; Wettschureck, N.: Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling. NATURE COMMUNICATIONS 16 (1), 1448 (2025)

Lingampally, A.; Truchi, M.; Mauduit, O.; Delcroix, V.; Vasquez-Pacheco, E.; Gautier-Isola, M.; Chu, X.; Khadim, A.; Chao, C.-M.; Zabihi, M. et al.; Taghizadeh, S.; Rivetti, S.; Marega, M.; Moiseenko, A.; Hadzic, S.; Vazquez-Armendariz, A. I.; Herold, S.; Guenther, S.; Millar-Buechner, P.; Koepke, J.; Samakovlis, C.; Wilhelm, J.; Bartkuhn, M.; Braun, T.; Weissmann, N.; Zhang, J.; Wygrecka, M.; Makarenkova, H. P.; Guenther, A.; Seeger, W.; Chen, C.; El Agha, E.; Mari, B.; Bellusci, S.: Evidence for a lipofibroblast-to-Cthrc1+ myofibroblast reversible switch during the development and resolution of lung fibrosis in young mice. EUROPEAN RESPIRATORY JOURNAL 65 (2), 2300482 (2025)

Jin, Y.-J.; Liang, G.; Li, R.; Wang, S.; Alnouri, M. W.; Bentsen, M.; Kuenne, C.; Guenther, S.; Yan, Y.; Li, Y. et al.; Wettschureck, N.; Offermanns, S.: Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression. NATURE CARDIOVASCULAR RESEARCH 4 (2) (2025)

Eibach, Y.; Kreher, S.; Poetsch, M. S.; Kho, A. L.; Gaertner, U.; Clemen, C. S.; Schroeder, R.; Guo, K.; Milting, H.; Meder, B. et al.; Potente, M.; Richter, M.; Schneider, A.; Meiners, S.; Gaute, M.; Braun, T.: The deubiquitinase USP5 prevents accumulation of protein aggregates in cardiomyocytes. SCIENCE ADVANCES 11 (4), eado3852 (2025)

Xie, L.; Jakutis, G.; Dooley, C. M.; Guenther, S.; Kontarakis, Z.; Howard, S.; Juan, T.; Stainier, D. Y. R.: Induction of a transcriptional adaptation response by RNA destabilization events. EMBO REPORTS (2025)

Cordero, J.; Swaminathan, G.; Rogel-Ayala, D. G.; Rubio, K.; Elsherbiny, A.; Mahmood, S.; Szymanski, W.; Graumann, J.; Braun, T.; Guenther, S. et al.; Dobreva, G.; Barreto, G.: Nuclear microRNA 9 mediates G-quadruplex formation and 3D genome organization during TGF-β-induced transcription. NATURE COMMUNICATIONS 15 (1), 10711 (2024)

Kothalawala, S. D.; Guenther, S.; Schuppe, H.-C.; Pilatz, A.; Wagenlehner, F.; Kliesch, S.; O'Donnell, L.; Fietz, D.: Identification of differentially expressed genes in human testis biopsies with defective spermatogenesis. REPRODUCTIVE MEDICINE AND BIOLOGY 23 (1), e12616 (2024)

Xu, Y.; Gehlot, R.; Capon, S. J.; Albu, P. M.; Gretz, J.; Bloomekatz, J.; Mattonet, K.; Vucicevic, D.; Talyan, S.; Kikhi, K. et al.; Guenther, S.; Looso, M.; Firulli, B. A.; Sanda, M.; Firulli, A. B.; Lacadie, S. A.; Yelon, D.; Stainier, D. Y. R.: PDGFRA is a conserved HAND2 effector during early cardiac development. NATURE CARDIOVASCULAR RESEARCH 3 (12) (2024)

Xu, Y.; Gehlot, R.; Capon, S. J.; Albu, M.; Gretz, J.; Bloomekatz, J.; Mattonet, K.; Vucicevic, D.; Talyan, S.; Kikhi, K. et al.; Guenther, S.; Looso, M.; Firulli, B. A.; Sanda, M.; Firulli, A. B.; Lacadie, S. A.; Yelon, D.; Stainier, D. Y. R.: PDGFRA is a conserved HAND2 effector during early cardiac development. NATURE CARDIOVASCULAR RESEARCH 3 (12) (2024)

Wang, Z.-Y.; Mehra, A.; Wang, Q.-C.; Gupta, S.; da Silva, A. R.; Juan, T.; Guenther, S.; Looso, M.; Detleffsen, J.; Stainier, D. Y. R. et al.; Marin-Juez, R.: flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response. DEVELOPMENT 151 (23), dev203028 (2024)

Teichmann, T.; Pflueger-Mueller, B.; Gimenez, V. M. M.; Sailer, F.; Dirks, H.; Zehr, S.; Warwick, T.; Brettner, F.; Munoz-Tello, P.; Zimmer, A. et al.; Tegeder, I.; Thomas, D.; Gurke, R.; Guenther, S.; Heering, J.; Proschak, E.; Geisslinger, G.; Bibli, I.-S.; zu Heringdorf, D. M.; Manucha, W.; Windbergs, M.; Knapp, S.; Weigert, A.; Leisegang, M. S.; Kojetin, D.; Brandes, R. P.: The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors. BRITISH JOURNAL OF PHARMACOLOGY (2024)

Gamez-Garcia, A.; Espinosa-Alcantud, M.; Bueno-Costa, A.; Alari-Pahissa, E.; Marazuela-Duque, A.; Thackray, J. K.; Ray, C.; Berenguer, C.; Kumari, P.; Bech, J. J. et al.; Braun, T.; Ianni, A.; Tischfield, J. A.; Serrano, L.; Esteller, M.; Sardina, J. L.; de la Torre, C.; Sigvardsson, M.; Vazquez, B. N.; Vaquero, A.: A SIRT7-dependent acetylation switch regulates early B cell differentiation and lineage commitment through Pax5. NATURE IMMUNOLOGY (2024)

Li, X.; Kempf, S.; Lagos, F. D.; Ukan, U.; Popp, R.; Hu, J.; Froemel, T.; Guenther, S.; Weigert, A.; Fleming, I.: A regulatory loop involving the cytochrome P450-soluble epoxide hydrolase axis and TGF-β signaling. ISCIENCE 27 (10), 110938 (2024)

Alnouri, M. W.; Roquid, K. A.; Bonnavion, R.; Cho, H.; Heering, J.; Kwon, J.; Jaeger, Y.; Wang, S.; Guenther, S.; Wettschureck, N. et al.; Geisslingerb, G.; Gurke, R.; Mueller, C. E.; Proschak, E.; Offermanns, S.: SPMs exert anti- inflammatory and pro- resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (41), e2407130121 (2024)