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Journal Article (45)

2021
Journal Article
Brunn, D.; Turkowski, K.; Gunther, S.; Weigert, A.; Muley, T.; Kriegsmann, M.; Winter, H.; Dammann, R. H.; Stathopoulos, G. T.; Thomas, M. et al.; Guenther, A.; Grimminger, F.; Pullamsetti, S. S.; Seeger, W.; Savai, R.: Interferon Regulatory Factor 9 Promotes Lung Cancer Progression via Regulation of Versican. CANCERS 13 (2), 208 (2021)
2020
Journal Article
Strack, E.; Rolfe, P. A.; Fink, A. F.; Bankov, K.; Schmid, T.; Solbach, C.; Savai, R.; Sha, W.; Pradel, L.; Hartmann, S. et al.; Bruene, B.; Weigert, A.: Identification of tumor-associated macrophage subsets that are associated with breast cancer prognosis. CLINICAL AND TRANSLATIONAL MEDICINE 10 (8), e239 (2020)
Journal Article
Kuester, M. M.; Schneider, M. A.; Richter, A. M.; Richtmann, S.; Winter, H.; Kriegsmann, M.; Pullamsetti, S. S.; Stiewe, T.; Savai, R.; Muley, T. et al.; Dammann, R. H.: Epigenetic Inactivation of the Tumor Suppressor IRX1 Occurs Frequently in Lung Adenocarcinoma and Its Silencing Is Associated with Impaired Prognosis. CANCERS 12 (12), 3528 (2020)
Journal Article
Olesch, C.; Sirait-Fischer, E.; Berkefeld, M.; Fink, A. F.; Susen, R. M.; Ritter, B.; Michels, B. E.; Steinhilber, D.; Greten, F. R.; Savai, R. et al.; Takeda, K.; Bruene, B.; Weigert, A.: S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8(+) T cell expansion. JOURNAL OF CLINICAL INVESTIGATION 130 (10), pp. 5461 - 5476 (2020)
Journal Article
Zheng, X.; Mansouri, S.; Krager, A.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Wheelock, C. E.; Savai, R.: Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment. EUROPEAN RESPIRATORY REVIEW 29 (157), 200134 (2020)
Journal Article
Baig, M. S.; Roy, A.; Rajpoot, S.; Liu, D.; Savai, R.; Banerjee, S.; Kawada, M.; Faisal, S. M.; Saluja, R.; Saqib, U. et al.; Ohishi, T.; Wary, K. K.: Tumor-derived exosomes in the regulation of macrophage polarization. INFLAMMATION RESEARCH 69 (5), pp. 435 - 451 (2020)
Journal Article
El-Nikhely, N.; Karger, A.; Sarode, P.; Singh, I.; Weigert, A.; Wietelmann, A.; Stiewe, T.; Dammann, R.; Fink, L.; Grimminger, F. et al.; Barreto, G.; Seeger, W.; Pullamsetti, S. S.; Rapp, U. R.; Savai, R.: Metastasis-Associated Protein 2 Represses NF-kappa B to Reduce Lung Tumor Growth and Inflammation. CANCER RESEARCH 80 (19), pp. 4199 - 4211 (2020)
Journal Article
Pullamsetti, S. S.; Mamazhakypov, A.; Weissmann, N.; Seeger, W.; Savai, R.: Hypoxia-inducible factor signaling in pulmonary hypertension. JOURNAL OF CLINICAL INVESTIGATION 130 (11), pp. 5638 - 5651 (2020)
Journal Article
Salazar, Y.; Zheng, X.; Brunn, D.; Raifer, H.; Picard, F.; Zhang, Y.; Winter, H.; Guenther, S.; Weigert, A.; Weigmann, B. et al.; Dumoutier, L.; Renauld, J.-C.; Waisman, A.; Schmall, A.; Tufman, A.; Fink, L.; Bruene, B.; Bopp, T.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Huber, M.; Savai, R.: Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer. JOURNAL OF CLINICAL INVESTIGATION 130 (7), pp. 3560 - 3575 (2020)
Journal Article
Sarode, P.; Mansouri, S.; Karger, A.; Schaefer, M. B.; Grimminger, F.; Seeger, W.; Savai, R.: Epithelial cell plasticity defines heterogeneity in lung cancer. CELLULAR SIGNALLING 65, 109463 (2020)
Journal Article
Sarode, P.; Zheng, X.; Giotopoulou, G. A.; Weigert, A.; Kuenne, C.; Guenther, S.; Friedrich, A.; Gattenloehner, S.; Stiewe, T.; Bruene, B. et al.; Grimminger, F.; Stathopoulos, G. T.; Pullamsetti, S. S.; Seeger, W.; Savai, R.: Reprogramming of tumor-associated macrophages by targeting beta-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer. SCIENCE ADVANCES 6 (23), eaaz6105 (2020)
Journal Article
Sarode, P.; Schaefer, M. B.; Grimminger, F.; Seeger, W.; Savai, R.: Macrophage and Tumor Cell Cross-Talk Is Fundamental for Lung Tumor Progression: We Need to Talk. FRONTIERS IN ONCOLOGY 10, 324 (2020)
Journal Article
Turkowski, K.; Herzberg, F.; Guenther, S.; Brunn, D.; Weigert, A.; Meister, M.; Muley, T.; Kriegsmann, M.; Schneider, M. A.; Winter, H. et al.; Thomas, M.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Savai, R.: Fibroblast Growth Factor-14 Acts as Tumor Suppressor in Lung Adenocarcinomas. CELLS 9 (8), 1755 (2020)
Journal Article
Zheng, X.; Weigert, A.; Reu, S.; Guenther, S.; Mansouri, S.; Bassaly, B.; Gattenlohner, S.; Grimminger, F.; Pullamsetti, S. S.; Seeger, W. et al.; Winter, H.; Savai, R.: Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non-Small Cell Lung Carcinoma. CANCER RESEARCH 80 (20), pp. 4414 - 4425 (2020)
2019
Journal Article
Dabral, S.; Muecke, C.; Valasarajan, C.; Schmoranzer, M.; Wietelmann, A.; Semenza, G. L.; Meister, M.; Muley, T.; Seeger-Nukpezah, T.; Samakovlis, C. et al.; Weissmann, N.; Grimminger, F.; Seeger, W.; Savai, R.; Pullamsetti, S. S.: A RASSF1A-HIF1 alpha loop drives Warburg effect in cancer and pulmonary hypertension. NATURE COMMUNICATIONS 10, 2130 (2019)
Journal Article
Elwakeel, E.; Brueggemann, M.; Fink, A. F.; Schulz, M. H.; Schmid, T.; Savai, R.; Bruene, B.; Zarnack, K.; Weigert, A.: Phenotypic Plasticity of Fibroblasts during Mammary Carcinoma Development. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20 (18), 4438 (2019)
Journal Article
Hempel, F.; Roderfeld, M.; Savai, R.; Sydykov, A.; Irungbam, K.; Schermuly, R.; Voswinckel, R.; Koehler, K.; Churin, Y.; Kiss, L. et al.; Bier, J.; Pons-Kuehnemann, J.; Roeb, E.: Depletion of Bone Marrow-Derived Fibrocytes Attenuates TAA-Induced Liver Fibrosis in Mice. CELLS 8 (10), 1210 (2019)
Journal Article
Jia, Y.; Vong, J. S.-L.; Asafova, A.; Garvalov, B. K.; Caputo, L.; Cordero, J.; Singh, A.; Boettger, T.; Guenther, S.; Fink, L. et al.; Acker, T.; Barreto, G.; Seeger, W.; Braun, T.; Savai, R.; Dobreva, G.: Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET. JOURNAL OF EXPERIMENTAL MEDICINE 216 (6), pp. 1377 - 1395 (2019)
Journal Article
Rubio, K.; Singh, I.; Dobersch, S.; Sarvari, P.; Guenther, S.; Cordero, J.; Mehta, A.; Wujak, L.; Cabrera-Fuentes, H.; Chao, C.-M. et al.; Braubach, P.; Bellusci, S.; Seeger, W.; Guenther, A.; Preissner, K. T.; Wygrecka, M.; Savai, R.; Papy-Garcia, D.; Dobreva, G.; Heikenwalder, M.; Savai-Pullamsetti, S.; Braun, T.; Barreto, G.: Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis. NATURE COMMUNICATIONS 10, 2229 (2019)
Journal Article
Saqib, U.; Savai, R.; Liu, D.; Banerjee, S.; Baig, M. S.: Drug repositioning as an effective therapy for protease-activated receptor 2 inhibition. JOURNAL OF CELLULAR BIOCHEMISTRY 120 (2), pp. 1522 - 1526 (2019)
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