Publications of Stefan Offermanns

Cartura, M.; Aliraj, B.; Szymanski, W.; Park, C.; Ferrario, G.; Rezende, F.; Guven, B.; Bleckwehl, T.; Sachs, N.; Magdefessel, L. et al.; Dimmeler, S.; Muller, O. J.; Jo, H.; Offermanns, S.; Hayat, S.; Brandes, R. P.; Munch, C.; Graumann, J.; Weigert, A.; Fleming, I.; Siragusa, M.: Immunomodulatory endothelial cells contribute to T-cell recruitment and activation via antigen presentation on MHC II. CARDIOVASCULAR RESEARCH 122 (12), pp. 1672 - 1687 (2026)

Ilyas, I.; Evans, P. C.; Berk, B. C.; Offermanns, S.; Xu, S.: Endothelial to mesenchymal transition (EndMT) in atherosclerosis: mechanisms, models, and therapies. CARDIOVASCULAR RESEARCH 122 (12), pp. 1555 - 1572 (2026)

Kwon, J.; Persechino, M.; Shao, J.; Shamsara, J.; Spitznagel, B.; Salwig, I.; Sanda, M.; Offermanns, S.; Kolb, P.; Wettschureck, N.: Small molecule inhibitor of orphan GPCR dimerization improves host defense and blood pressure control in mice. JOURNAL OF CLINICAL INVESTIGATION 136 (15), e203162 (2026)

Zhang, Y.; Sun, Y.; Xu, G.; Wu, Y.; Shi, Z.; Chang, Z.; Liu, J.; Pang, K.; Liu, S.; Wang, H. et al.; Rong, W.; Shao, Z.; Liu, X.; He, Y.; Yan, Y.; Zhou, B.; Yuan, Z.; Zhang, X.-F.; Offermanns, S.; Wang, S.: Zonated mechanosensing by PIEZO1 controls liver regeneration. SCIENCE 393 (6806), eaef0825 (2026)

Shiva, N.; Kawase, H.; Einsiedel, J.; Kwon, J.; Kumar, S.; Shao, J.; Du, Z.; Kubin, N.; Shimari, M.; Gunther, S. et al.; Li, T.; Dierickx, P.; Sossalla, S.; Offermanns, S.; Gmeiner, P.; Wettschureck, N.: Neurotensin receptor 2 agonism attenuates adverse cardiac remodeling in preclinical models. SCIENCE TRANSLATIONAL MEDICINE 18 (856), eaea9877 (2026)

Hernandez-Olmos, V.; Heering, J.; Lillich, F. F.; Marinescu, B.; Nevermann, S.; Ehrler, J. H. M.; Radchenko, D. S.; Moroz, Y. S.; Kaiser, A.; Kramer, A. et al.; Knapp, S.; Schubert-Zsilavecz, M.; Alnouri, M. W.; Offermanns, S.; Steinhilber, D.; Sisignano, M.; Proschak, E.: First Structure-Activity-Relationship Study of Potent G2A Antagonists. JOURNAL OF MEDICINAL CHEMISTRY 69 (12), pp. 14309 - 14332 (2026)

Spyropoulos, D.; Kleindienst, L.; Ehrich, P.; Ziemens, D.; Natsagdorj, R.; Noll, N.; Hansen, C. E.; Gutt, A.-S.; Menyhart, A.; Sedlacik, J. et al.; Ludewig, P.; Lembrich, B.; Ozorhan, U.; Kostenis, E.; Fiehler, J.; Huttmann, G.; Longden, T. A.; Nogueiras, R.; Prevot, V.; Muller-Fielitz, H.; Offermanns, S.; Wettschureck, N.; Farkas, E.; Schwaninger, M.; Wenzel, J.: Brain endothelial Gα q/11 signalling in cerebrovascular function and cognition of aged mice. EBIOMEDICINE 128, 106283 (2026)

Siragusa, M.; Graumann, J.; Kuenne, C.; Gunther, S.; Jeratsch, S.; Guven, B.; Susser, S.; Talyan, S.; Bezuneh, B.; Matthess, Y. et al.; Cartura, M.; Zhou, X.; Cho, H.; Sachs, N.; Maegdefessel, L.; Muller, O. J.; Troidl, C.; Nef, H. M.; Looso, M.; Kaulich, M.; Offermanns, S.; Fleming, I.: Identification of unannotated microproteins involved in endothelial cell homeostasis, dysfunction, and vascular disease. CARDIOVASCULAR RESEARCH (2026)

Kawase, H.; Liu, S.; Kurz, S.; Bengelsdorff, V.; Bonnavion, R.; Jin, Y.-J.; Roquid, K. A.; Cho, H.; Liang, G.; Banicevic, M. et al.; Shiva, N.; Yunes-Leites, P. S.; Gunther, S.; Tombor, L.; Dimmeler, S.; Looso, M.; Mattonet, K.; Wettschureck, N.; Muller, U. C.; Offermanns, S.: Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis. SCIENCE ADVANCES 12 (21), eaeh0301 (2026)

Cao, Y.; Xu, L.; Zhang, M.; Su, A.; Wang, S.; Li, T.; Liu, S.; Mao, Z.; He, Y.; Shao, Z. et al.; Zhang, J.; Wang, Y.; Tian, H.; Sun, Y.; Li, Y.; Yan, L.; Zhang, G.; Sun, S.; Mei, N.; Chen, F.; Xiong, Y.; Liang, G.; Offermanns, S.; Yan, Y.; Yuan, Z.; Wang, S.: PIEZO1 regulates smooth muscle cell plasticity by integrating mechanical stretch with glycolytic metabolism. CARDIOVASCULAR RESEARCH 122 (6), pp. 748 - 763 (2026)

Cheng, C. K.; Meng, S.; Li, T.; Ding, H.; Jiang, M.; Tian, Z.; Ng, C.-f.; Xia, Y.; Offermanns, S.; Huang, Y.: Spatially Characterized Aortic Proteome Reveals Novel Regional Signatures and Glucocorticoid Receptor/Dipeptidase 1 Axis in Diabetic Vasculopathy. MEDCOMM 7 (4), e70714 (2026)

Zhou, X.; Kuenne, C.; Gunther, S.; Wittig, I.; Guven, B.; Boutguetait, D.; Delgado Lagos, F.; Sachs, N.; Maegdefessel, L.; Muller, O. J. et al.; Munch, C.; Offermanns, S.; Fleming, I.; Siragusa, M.: Nuclear eNOS Interacts With and S-Nitrosates ADAR1 to Modulate Type I Interferon Signaling and Endothelial Function. CIRCULATION 152 (25) (2025)

Rombach, A.; Geissler, M.; Xiao, L.; Qasem, L.-E.; Stange, L.; Prinz, V.; Jussen, D.; Landolsi, S.; Kokkaliaris, K. D.; Medyouf, H. et al.; Sevenich, L.; Zeiner, P.; Reiss, Y.; Cakmak, P.; Armbrust, M.; Weber, K. J.; Plate, K. H.; Offermanns, S.; Broggini, T.; Czabanka, M.: Impact of preoperative clinical patient parameters on surgically obtained brain metastasis samples for translational research. MOLECULAR AND CELLULAR PROBES 84, 102055 (2025)

Roquid, K. A.; Vucetic, A.; Dyukova, E.; Hanssen , M. J.; Cho, H.; Bonnavion, R.; Mattonet, K.; Looso, M.; Sanda, M.; Strilic, B. et al.; Offermanns, S.: Lung endothelial PEAR1 induces tumor cell dormancy. MOLECULAR CANCER 24 (1), 278 (2025)

Mahmoud, W.; Perniss, A.; Poharkar, K.; Keshavarz, M.; Gartner, U.; Oberwinkler, J.; Schutz, B.; Worzfeld, T.; Offermanns, S.; Kummer, W.: Differential expression of villin and advillin by neuroendocrine and tuft cells in the murine lower airways. CELL AND TISSUE RESEARCH 402 (1), pp. 1 - 20 (2025)

Franck, L.; Hahnefeld, L.; Valek, L.; Klatt-Schreiner, K.; Wilken-Schmitz, A.; Alnouri, M. W.; Trautmann, S.; Weyer, M.-P.; Thomas, D.; Gurke, R. et al.; Offermanns, S.; Geisslinger, G.; Tegeder, I.: Elevated hexosylceramides in Parkinson's disease cause gene upregulations in neurons mimicking responses to pathogens. NPJ PARKINSONS DISEASE 11 (1), 268 (2025)

Dutzmann, J.; Daniel, J.-M.; Korte, L.; Kloss, F. J.; Knoepp, K.; Kalies, K.; Croce, K. J.; Herbst, T. J.; Huibregtse, B.; Vogt, F. J. et al.; Offermanns, S.; Bauersachs, J.; Sedding, D. G.: Adventitial Fibroblasts Release Interleukin 6 After Vascular Injury and Induce Smooth Muscle Cell Proliferation and Neointima Formation. JOURNAL OF THE AMERICAN HEART ASSOCIATION 14 (14), e040143 (2025)

Shao, J.; Kwon, J.; Wang, T.; Guenther, S.; Tombor, L. S.; Warwick, T.; Shaheryar, Z.; Brandes, R. P.; Dimmeler, S.; Wenzel, J. et al.; Offermanns, S.; Schwaninger, M.; Wettschureck, N.: Orphan receptor GPR153 facilitates vascular damage responses by modulating cAMP levels, YAP/TAZ signaling, and NF-κB activation. NATURE COMMUNICATIONS 16 (1), 6232 (2025)

Xu, L.; Li, T.; Cao, Y.; He, Y.; Shao, Z.; Liu, S.; Wang, B.; Su, A.; Tian, H.; Li, Y. et al.; Liang, G.; Wang, C.; Shyy, J.; Xiong, Y.; Chen, F.; Yuan, J. X.J.; Liu, J.; Zhou, B.; Wettschureck, N.; Offermanns, S.; Yan, Y.; Yuan, Z.; Wang, S.: PIEZO1 mediates periostin myofibroblast activation and pulmonary fibrosis in mice. JOURNAL OF CLINICAL INVESTIGATION 135 (11), e184158 (2025)

Leko, L.; Simic, D.; Martins, T. V.; da Silva, G. V. L.; Maillet, I.; Savigny, F.; Vuksan, L.; Rodrigues, D. d. M.; Le Bert, M.; Offermanns, S. et al.; Riteau, N.; Togbe, D.; Quesniaux, V. F.; Russo, R. C.; Alves-Filho, J. C.; Ryffel, B.: Butyrate receptor HCAR2/GPR109A controls imiquimod-induced psoriasis-like skin inflammation. JOURNAL OF IMMUNOLOGY (2025)