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Full muscle power only with TAF4A: If the transcription factor is active in muscle stem cells, the cell nuclei are intact (top left), while the absence of TAF4A results in unstable cell nuclei (top right). As a result, the regenerative capacity of muscles (bottom row) without TAF4A (right) is severely impaired. In comparison, the muscle cells in the tissue section of control animals with TAF4A appear regular and intact.

Transcription factor TAF4A preserves nuclei in muscle stem cells and initiates muscle regeneration after injury
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Smooth muscle cells under a fluorescence microscope

GPR153 promotes inflammatory reactions in the vessel wall in response to acute damage more

Digital image of the heart in a human chest

RBPMS and RBPMS2 regulate cell division and function during heart development more

A team of researchers at the Max Planck Institute for Heart and Lung Research, led by Prof. Dr. Didier Y.R. Stainier, has been awarded a prestigious ERC Proof of Concept (PoC) grant to advance a groundbreaking RNA-based therapeutic strategy for Duchenne Muscular Dystrophy (DMD). more

Award ceremony, several people on stage

Foundation of the former German President and his wife honours innovative therapeutic approach for Duchenne muscular dystrophy more

The picture shows the logo of the CPI and the logos of the Institute, the University of Giessen and the University of Frankfurt around it

Max Planck Institute again successful together with Universities of Giessen and Frankfurt in Federal Excellence Initiative more

Timing is everything

March 26, 2025

On Sunday, March 30, 2025, the clocks in Germany will spring forward for daylight saving time. While we all adjust our watches, phones, and computers, what does this shift really do to our bodies? Experts from three different Max Planck Institutes shed light on this question. more

Microscopic view of stained cells with visible nuclei.

GPRC5B influences the Prostaglandin Receptor and affects the immune response more

Microscopic image of muscle tissue featuring pink-stained muscle fibers intertwined with blue-stained connective tissue, highlighting cellular detail.

Utrophin increase in muscle cells via transcriptional adaptation normalises cell function in Duchenne muscular dystrophy more

Fast Food in Restaurant

The hormone triggers insulin resistance in blood vessel endothelium in obesity more

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