Publikationen von Stefan Offermanns

Rombach, A.; Geissler, M.; Xiao, L.; Qasem, L.-E.; Stange, L.; Prinz, V.; Jussen, D.; Landolsi, S.; Kokkaliaris, K. D.; Medyouf, H. et al.; Sevenich, L.; Zeiner, P.; Reiss, Y.; Cakmak, P.; Armbrust, M.; Weber, K. J.; Plate, K. H.; Offermanns, S.; Broggini, T.; Czabanka, M.: Impact of preoperative clinical patient parameters on surgically obtained brain metastasis samples for translational research. MOLECULAR AND CELLULAR PROBES 84, 102055 (2025)

Roquid, K. A.; Vucetic, A.; Dyukova, E.; Hanssen , M. J.; Cho, H.; Bonnavion, R.; Mattonet, K.; Looso, M.; Sanda, M.; Strilic, B. et al.; Offermanns, S.: Lung endothelial PEAR1 induces tumor cell dormancy. MOLECULAR CANCER 24 (1), 278 (2025)

Mahmoud, W.; Perniss, A.; Poharkar, K.; Keshavarz, M.; Gartner, U.; Oberwinkler, J.; Schutz, B.; Worzfeld, T.; Offermanns, S.; Kummer, W.: Differential expression of villin and advillin by neuroendocrine and tuft cells in the murine lower airways. CELL AND TISSUE RESEARCH 402 (1), S. 1 - 20 (2025)

Franck, L.; Hahnefeld, L.; Valek, L.; Klatt-Schreiner, K.; Wilken-Schmitz, A.; Alnouri, M. W.; Trautmann, S.; Weyer, M.-P.; Thomas, D.; Gurke, R. et al.; Offermanns, S.; Geisslinger, G.; Tegeder, I.: Elevated hexosylceramides in Parkinson's disease cause gene upregulations in neurons mimicking responses to pathogens. NPJ PARKINSONS DISEASE 11 (1), 268 (2025)

Dutzmann, J.; Daniel, J.-M.; Korte, L.; Kloss, F. J.; Knoepp, K.; Kalies, K.; Croce, K. J.; Herbst, T. J.; Huibregtse, B.; Vogt, F. J. et al.; Offermanns, S.; Bauersachs, J.; Sedding, D. G.: Adventitial Fibroblasts Release Interleukin 6 After Vascular Injury and Induce Smooth Muscle Cell Proliferation and Neointima Formation. JOURNAL OF THE AMERICAN HEART ASSOCIATION 14 (14), e040143 (2025)

Shao, J.; Kwon, J.; Wang, T.; Guenther, S.; Tombor, L. S.; Warwick, T.; Shaheryar, Z.; Brandes, R. P.; Dimmeler, S.; Wenzel, J. et al.; Offermanns, S.; Schwaninger, M.; Wettschureck, N.: Orphan receptor GPR153 facilitates vascular damage responses by modulating cAMP levels, YAP/TAZ signaling, and NF-κB activation. NATURE COMMUNICATIONS 16 (1), 6232 (2025)

Xu, L.; Li, T.; Cao, Y.; He, Y.; Shao, Z.; Liu, S.; Wang, B.; Su, A.; Tian, H.; Li, Y. et al.; Liang, G.; Wang, C.; Shyy, J.; Xiong, Y.; Chen, F.; Yuan, J. X.J.; Liu, J.; Zhou, B.; Wettschureck, N.; Offermanns, S.; Yan, Y.; Yuan, Z.; Wang, S.: PIEZO1 mediates periostin myofibroblast activation and pulmonary fibrosis in mice. JOURNAL OF CLINICAL INVESTIGATION 135 (11), e184158 (2025)

Leko, L.; Simic, D.; Martins, T. V.; da Silva, G. V. L.; Maillet, I.; Savigny, F.; Vuksan, L.; Rodrigues, D. d. M.; Le Bert, M.; Offermanns, S. et al.; Riteau, N.; Togbe, D.; Quesniaux, V. F.; Russo, R. C.; Alves-Filho, J. C.; Ryffel, B.: Butyrate receptor HCAR2/GPR109A controls imiquimod-induced psoriasis-like skin inflammation. JOURNAL OF IMMUNOLOGY (2025)

Kosinska, J.; Assmann, J. C.; Inderhees, J.; Mueller-Fielitz, H.; Haendler, K.; Geisler, S.; Kuenstner, A.; Busch, H.; Worthmann, A.; Heeren, J. et al.; Sadik, C. D.; Gunzer, M.; Prevot, V.; Nogueiras, R.; Hirose, M.; Spielmann, M.; Offermanns, S.; Wettschureck, N.; Schwaninger, M.: Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR2. ELIFE 14, e98970 (2025)

Chen, X.; Shao, J.; Brandenburger, I.; Qian, W.; Hahnefeld, L.; Bonnavion, R.; Cho, H.; Wang, S.; Hidalgo, J.; Wettschureck, N. et al.; Geisslinger, G.; Gurke, R.; Wang, Z.; Offermanns, S.: FFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes. NATURE COMMUNICATIONS 16 (1), 3422 (2025)

Sun, L.; Leng, R.; Liu, M.; Su, M.; He, Q.; Zhang, Z.; Liu, Z.; Wang, Z.; Jiang, H.; Wang, L. et al.; Guo, S.; Xu, Y.; Huo, Y.; Miller, C. L.; Banach, M.; Huang, Y.; Evans, P. C.; Pelisek, J.; Camici, G. G.; Berk, B. C.; Offermanns, S.; Ge, J.; Xu, S.; Weng, J.: Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake. JOURNAL OF CLINICAL INVESTIGATION 135 (7), e181928 (2025)

Xu, S.; Liu, Z.; Tian, T.; Zhao, W.; Wang, Z.; Liu, M.; Xu, M.; Zhang, F.; Zhang, Z.; Chen, M. et al.; Yin, Y.; Su, M.; Fang, W.; Pan, W.; Liu, S.; Li, M.-d.; Little, P. J.; Kamato, D.; Zhang, S.; Wang, D.; Offermanns, S.; Speakman, J. R.; Weng, J.: The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21. SCIENCE ADVANCES 11 (13), eadt3142 (2025)

Cho, H.; Lai, C.-C.; Bonnavion, R.; Alnouri, M. W.; Wang, S.; Roquid, K. A.; Kawase, H.; Campos, D.; Chen, M.; Weinstein, L. S. et al.; Martinez, A.; Looso, M.; Sanda, M.; Offermanns, S.: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. SCIENCE 387 (6734), S. 674 - 682 (2025)

Cho, H.; Lai, C.-C.; Bonnavion, R.; Alnouri, M. W.; Wang, S.; Roquid, K. A.; Kawase, H.; Campos, D.; Chen, M.; Weinstein, L. S. et al.; Martinez, A.; Looso, M.; Sanda, M.; Offermanns, S.: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. SCIENCE 387 (6734), S. 674 - 682 (2025)

Kwon, J.; Haruya, K.; Mattonet, K.; Guenther, S.; Hahnefeld, L.; Shamsara, J.; Heering, J.; Kurz, M.; Kirchhofer, S.; Krasel, C. et al.; Ulrich, M.; Persechino, M.; Murthy, S.; Orlandi, C.; Sadik, C. D.; Geisslinger, G.; Buenemann, M.; Kolb, P.; Offermanns, S.; Wettschureck, N.: Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling. NATURE COMMUNICATIONS 16 (1), 1448 (2025)

Jin, Y.-J.; Liang, G.; Li, R.; Wang, S.; Alnouri, M. W.; Bentsen, M.; Kuenne, C.; Guenther, S.; Yan, Y.; Li, Y. et al.; Wettschureck, N.; Offermanns, S.: Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression. NATURE CARDIOVASCULAR RESEARCH 4 (2) (2025)

Su, M.; Zhao, W.; Jiang, H.; Zhao, Y.; Liao, Z.; Liu, Z.; Xu, M.; Jiang, S.; Wu, L.; Yang, Y. et al.; Wang, Z.; Zeng, Z.; Fang, Y.; Tang, C.; Miller, C. L.; Evans, P. C.; Wang, L.; Banach, M.; Jo, H.; Berk, B. C.; Offermanns, S.; Huang, Y.; Ge, J.; Xu, S.; Weng, J.: Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis. NATURE CARDIOVASCULAR RESEARCH 4 (2) (2025)

Hernandez-Olmos, V.; Heering, J.; Ildefeld, N.; Ehrler, J. H. M.; Kaps, A.; Rajkumar, R.; Marinescu, B.; Kaiser, A.; Macinkovic, I.; Elewa, M. A. F. et al.; Alnouri, M. W.; Elson, L.; Schubert-Zsilavecz, M.; Kallenborn-Gerhardt, W.; Schmidtko, A.; Mueller, S.; Offermanns, S.; Steinhilber, D.; Weigert, A.; Proschak, E.: Identification of a Chemical Probe for BLT2 Activation by Scaffold Hopping. JOURNAL OF MEDICINAL CHEMISTRY 68 (2), S. 1195 - 1221 (2025)

Yoshida, T.; Yoshida, S.; Inukai, K.; Kato, K.; Yura, Y.; Hattori, T.; Taki, K.; Enomoto, A.; Ohashi, K.; Okumura, T. et al.; Ouchi, N.; Kawase, H.; Wettschureck, N.; Offermanns, S.; Murohara, T.; Takefuji, M.: ALPK2 prevents cardiac diastolic dysfunction in heart failure with preserved ejection fraction. FASEB JOURNAL 38 (22), e70192 (2024)

Alnouri, M. W.; Roquid, K. A.; Bonnavion, R.; Cho, H.; Heering, J.; Kwon, J.; Jaeger, Y.; Wang, S.; Guenther, S.; Wettschureck, N. et al.; Geisslingerb, G.; Gurke, R.; Mueller, C. E.; Proschak, E.; Offermanns, S.: SPMs exert anti- inflammatory and pro- resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (41), e2407130121 (2024)