The Max Planck Institute for Heart and Lung Research (Dr. Karin Ziegler)  in Bad Nauheim (near Frankfurt, Germany) invites applications for a PhD Student (m/f/d) to study the molecular mechanisms of sympathetic dysfunction in disease ,Reference number 2026_07.

The Max Planck Institute for Heart and Lung Research in Bad Nauheim is an internationally renowned research institute. It conducts basic research primarily in the field of the cardiovascular system and organ biology. The institute currently comprises three departments, several independent research groups, and central scientific service groups. A total of approximately 380 people are currently employed at the institute.

Job Description

Sympathetic overactivity is a key driver of heart failure progression, yet the molecular mechanisms linking neuronal activation to pathological cardiac remodeling remain incompletely understood. This PhD project will investigate how sympathetic ganglia sense disease and reprogram themselves, initiating waves of inflammation and tissue remodeling in the heart. Specifically, you will use advanced molecular profiling (single-nucleus transcriptomics, proteomics), imaging, and functional assays in mouse models to identify key molecular nodes linking sympathetic overactivation, immune cell infiltration, and cardiac fibrosis. Your findings will point toward novel pharmacological targets for preventing maladaptive remodeling - work with genuine translational potential. You will lead your own research sub-project within this framework, with guidance from Dr. Karin Ziegler.

You will:

• Design and execute experiments investigating sympathetic remodeling mechanisms in (in vivo, in vitro and ex vivo) disease models
• Apply cutting-edge omics and imaging techniques to characterize cellular and molecular changes
• Analyze complex datasets and generate biological insights
• Contribute to group seminars, manuscript preparation, and lab discussions

Requirements

The ideal candidate has the following qualifications:

• Successfully completed scientific university studies (Master’s degree) in a relevant field such as biology, biochemistry or a related discipline with a strong focus on molecular biology, cell biology or biochemistry is preferred
• Demonstrated research independence and scientific curiosity
• Fluent English (written and oral)
• Previous experience working with mice or rats is an advantage but not required

Our Offer

• An opportunity to work in an international team
• Our researchers have the opportunity to work on various model systems by making use of the latest cutting-edge technologies
• Researchers are supported by state-of-the-art core facilities which offer services in next-generation sequencing, proteomics, bioinformatics, cytometry, microscopy, and small animal imaging

The Max Planck Society is committed to increase the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals. Furthermore, The Max Planck Society strives for gender and diversity equality. We welcome applications from all backgrounds.

Your Application

Are you interested? Then we look forward to receiving your application! Please provide the following documents via our applicant portal by 08.02.2026:

1. Curriculum Vitae (max 2 pages): Education, research experience (with brief description of each role and key findings), technical skills, publications/presentations, awards
2. Letter of Motivation (max 1 page):
   • Why you're interested in sympathetic dysfunction and cardiac remodeling
   • What attracted you to this project and Dr. Ziegler's group
   • How this PhD aligns with your career goals
   • Any research background or skills that make you a strong fit
3. Contact Information for 2–3 References: Names, titles, institutions, emails (ideally your Master's thesis advisor and 1–2 research supervisors)
4. Academic Transcripts