ATAC-seq footprinting identifies dynamic transcription factor binding

Research report (imported) 2020 - Max Planck Institute for Heart and Lung Research - W. G. Kerckhoff Institute

Looso, Mario
Max-Planck-Institut für Herz- und Lungenforschung, Bad Nauheim, IT-Abteilung
Transcription factors are key regulators of complex genetic programs such as cell maturation, differentiation, or proliferation. Due to their central role, the identification of transcription factor binding positions is crucial to understand and predict cellular fate decisions. We have developed a computational method that utilizes a chromatin-accessibility assay to survey which transcription factors are active, and which genes they activate. This approach aims to unravel transcription factors dynamics and networks.

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