CPI Research Group Epigenetics
Gu lab at the MPI-HLR will combine bioinformatics, epigenomics, cancer biology, fly genetics and mass spectrum to further identify and investigate the possible roles of novel epigenetic modifications and their regulating enzymes in aging, development and diseases including cancer, and novel mechanisms in transgenerational epigenetics inheritance. Dr. Gu’s team is excited to be a part of the MPI-HLR and CPI. Its outstanding faculty and multi-disciplinary research environment would provide an ideal place for the team to pursue their research goals. Likewise, Gu lab will also be able to contribute to the MPI-HLR and CPI at multiple different levels.
Dr. Lei Gu obtained his Ph.D. in bioinformatics and cancer biology from the German Cancer Research Center and combined Faculties for Biosciences and Mathematics at Heidelberg University in Germany in December 2013. He then moved to Harvard Medical School and Boston Childrens Hospital for postdoc training in biochemistry. Since 2019, Dr. Gu was promoted as Instructor in Pediatrics at Boston Childrens Hospital and Harvard Medical School to investigate basic and applied epigenetics using both experimental and computational approaches. Dr.Gu published his research results in many prestige scientific journals including Nature, Cell, Nature Genetics, Cancer Cell, Nature Protocols and Bioinformatics. His published works have been cited for around 5000 times and the h-index reaches 25 in 2021. In April 2021, Dr. Gu officially joined in MPI-HLR and CPI as an independent group leader.
Lab members
I joined MPI-HLR as an independent group leader in 2021 and was an instructor in Pediatrics at Harvard Medical School and the Division of Newborn Medicine at Boston Childrens Hospital. I received my PhD from Heidelberg University in Germany, and postdoc training at Harvard Medical School in USA. My lab is interested in understanding how epigenetic information is inherited from generation to generation, and applying the identified fundamental epigenetic mechanisms to improve the health of human being and cure diseases.
Hobby: football, Texas hold'em, trading and investment
I am an evolutionary biologist and I am interested in the evolution of life-history, in particular in anything revolving around trade-offs and understanding the genetics unerpinning these correlations. Drosophila melanogaster is one of my favorite model organisms, and in particular I am interested in the symbiont Wolbachia, and the possible evolutionary consequences that this could have on population of D. melanogaster.
My hobbies mainly revolve around visiting new places, reading and the world of medieval texts and literature! I also enjoy trying creative new things, the recent ones being like emboidery and cross-stitching.
I have a MSc in biochemistry and molecular biology (2021) from Southwest University, China, and join IMPRS program as a doctoral student of Dr. Gu's group at MPI-HLR. I am interested in Wolbachia, evolution, epigenetics, and bioinformatics. My Ph.D. studies will work on the relationship between Wolbachia and epigenetic modification using Drosophila melanogaster as a model, which needs to be illustrated by the combination of multi-omics integration research, molecular works, and bioinformatic analysis. hobby: swimming, travel, badminton, drum sets
I am currently doing my Master's degree in Bioinformatics at the Justus Liebig University in Giessen. I am an intern and work under Gu Lei on epigenetic mechanisms in regulating responses of tumors to immune therapy. In my spare time, I am interested in 3D printing, the thickest fantasy
novels I can find, and all the creepy crawlers you can think of.
