Possible role of cell receptor P2Y10 for autoimmune diseases

Research report (imported) 2021 - Max Planck Institute for Heart and Lung Research - W. G. Kerckhoff Institute

Authors
Wettschureck, Nina
Departments
Abteilung Pharmakologie
Summary
An important part of the immune defense is the migration of leukocytes to the site of the inflammatory stimulus. This is mediated by chemical messengers whose counterparts are receptors on the surface of immune cells. Our Team from the ”G-protein signalling group” has now explored the role of a G protein-coupled receptor called P2Y10 in CD4 T cells. Mice lacking this receptor show less pronounced autoimmune responses in experiments. The study shows that P2Y10 may play a role in neurodegenerative diseases such as multiple sclerosis or other autoimmune diseases.
 

For the full text, see the German version.

Zur Redakteursansicht