A critical factor of patient survival and a potential treatment strategy for angiosarcoma
Research report (imported) 2019 - Max Planck Institute for Heart and Lung Research - W. G. Kerckhoff Institute
Cell polarity is a fundamental feature that is required for proper tissue function. Loss of polarity causes tissue disorganization and excessive cell growth. In highly malignant tumors, the polarity protein aPKCλ is often over-expressed and mislocalized However, the molecular mechanisms connecting cell polarization to cell proliferation so far remained elusive. We identified a critical factor for patient prognosis and propose a novel therapeutic strategy.