A critical factor of patient survival and a potential treatment strategy for angiosarcoma

Cell polarity is a fundamental feature that is required for proper tissue function. Loss of polarity causes tissue disorganization and excessive cell growth. In highly malignant tumors, the polarity protein aPKCλ is often over-expressed and mislocalized  However, the molecular mechanisms connecting cell polarization to cell proliferation so far remained elusive. We identified a critical factor for patient prognosis and propose a novel therapeutic strategy.