Publications of Shengpeng Wang

Xu, L.; Li, T.; Cao, Y.; He, Y.; Shao, Z.; Liu, S.; Wang, B.; Su, A.; Tian, H.; Li, Y. et al.; Liang, G.; Wang, C.; Shyy, J.; Xiong, Y.; Chen, F.; Yuan, J. X.J.; Liu, J.; Zhou, B.; Wettschureck, N.; Offermanns, S.; Yan, Y.; Yuan, Z.; Wang, S.: PIEZO1 mediates periostin myofibroblast activation and pulmonary fibrosis in mice. JOURNAL OF CLINICAL INVESTIGATION 135 (11), e184158 (2025)

Chen, X.; Shao, J.; Brandenburger, I.; Qian, W.; Hahnefeld, L.; Bonnavion, R.; Cho, H.; Wang, S.; Hidalgo, J.; Wettschureck, N. et al.; Geisslinger, G.; Gurke, R.; Wang, Z.; Offermanns, S.: FFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes. NATURE COMMUNICATIONS 16 (1), 3422 (2025)

Cho, H.; Lai, C.-C.; Bonnavion, R.; Alnouri, M. W.; Wang, S.; Roquid, K. A.; Kawase, H.; Campos, D.; Chen, M.; Weinstein, L. S. et al.; Martinez, A.; Looso, M.; Sanda, M.; Offermanns, S.: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. SCIENCE 387 (6734), pp. 674 - 682 (2025)

Cho, H.; Lai, C.-C.; Bonnavion, R.; Alnouri, M. W.; Wang, S.; Roquid, K. A.; Kawase, H.; Campos, D.; Chen, M.; Weinstein, L. S. et al.; Martinez, A.; Looso, M.; Sanda, M.; Offermanns, S.: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. SCIENCE 387 (6734), pp. 674 - 682 (2025)

Jin, Y.-J.; Liang, G.; Li, R.; Wang, S.; Alnouri, M. W.; Bentsen, M.; Kuenne, C.; Guenther, S.; Yan, Y.; Li, Y. et al.; Wettschureck, N.; Offermanns, S.: Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression. NATURE CARDIOVASCULAR RESEARCH 4 (2) (2025)

Alnouri, M. W.; Roquid, K. A.; Bonnavion, R.; Cho, H.; Heering, J.; Kwon, J.; Jaeger, Y.; Wang, S.; Guenther, S.; Wettschureck, N. et al.; Geisslingerb, G.; Gurke, R.; Mueller, C. E.; Proschak, E.; Offermanns, S.: SPMs exert anti- inflammatory and pro- resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (41), e2407130121 (2024)

Wang, S.; Wang, B.; Shi, Y.; Moeller, T.; Stegmeyer I, R.; Strilic, B.; Li, T.; Yuan, Z.; Wang, C.; Wettschureck, N. et al.; Vestweber, D.; Offermanns, S.: Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis. BLOOD 140 (3), pp. 171 - 183 (2022)

Liang, G.; Wang, S.; Shao, J.; Jin, Y.-J.; Xu, L.; Yan, Y.; Guenther, S.; Wang, L.; Offermanns, S.: Tenascin-X Mediates Flow-Induced Suppression of EndMT and Atherosclerosis. CIRCULATION RESEARCH 130 (11), pp. 1647 - 1659 (2022)

Peng, Y.; Du, J.; Gunther, S.; Guo, X.; Wang, S.; Schneider, A.; Zhu, L.; Braun, T.: Mechano-signaling via Piezo1 prevents activation and p53-mediated senescence of muscle stem cells. REDOX BIOLOGY 52, 102309 (2022)

Wang, S.; Wang, B.; Shi, Y.; Moller, T.; Stegmeyer, R. I.; Strilic, B.; Li, T.; Yuan, Z.; Wang, C.; Wettschureck, N. et al.; Vestweber, D.; Offermanns, S.: Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis. Blood (2022)

Jin, Y.-J.; Chennupati, R.; Li, R.; Liang, G.; Wang, S.; Iring, A.; Graumann, J.; Wettschureck, N.; Offermanns, S.: Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation. JOURNAL OF CLINICAL INVESTIGATION 131 (21), e145734 (2021)

Xu, L.; Wettschureck, N.; Bai, Y.; Yuan, Z.; Wang, S.: Myofibroblast YAP/TAZ is dispensable for liver fibrosis in mice. JOURNAL OF HEPATOLOGY 75 (1), pp. 238 - 241 (2021)

Wang, L.; Rice, M.; Swist, S.; Kubin, T.; Wu, F.; Wang, S.; Kraut, S.; Weissmann, N.; Boettger, T.; Wheeler, M. et al.; Schneider, A.; Braun, T.: BMP9 and BMP10 Act Directly on Vascular Smooth Muscle Cells for Generation and Maintenance of the Contractile State. CIRCULATION 143 (14), pp. 1394 - 1410 (2021)

Wang, L.; Chennupati, R.; Jin, Y.-J.; Li, R.; Wang, S.; Guenther, S.; Offermanns, S.: YAP/TAZ Are Required to Suppress Osteogenic Differentiation of Vascular Smooth Muscle Cells. ISCIENCE 23 (12), 101860 (2020)

Wang, L.; Wang, S.; Shi, Y.; Li, R.; Guenther, S.; Ong, Y. T.; Potente, M.; Yuan, Z.; Liu, E.; Offermanns, S.: YAP and TAZ protect against white adipocyte cell death during obesity. NATURE COMMUNICATIONS 11 (1), 5455 (2020)

Stanicek, L.; Lozano-Vidal, N.; Bink, D. I.; Hooglugt, A.; Yao, W.; Wittig, I.; van Rijssel, J.; van Buul, J. D.; van Bergen, A.; Klems, A. et al.; Ramms, A. S.; Le Noble, F.; Hofmann, P.; Szulcek, R.; Wang, S.; Offermanns, S.; Ercanoglu, M. S.; Kwon, H.-B.; Stainier, D.; Huveneers, S.; Kurian, L.; Dimmeler, S.; Boon, R. A.: Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function. COMMUNICATIONS BIOLOGY 3 (1), 265 (2020)

Wang, S.; Cao, S.; Arhatte, M.; Li, D.; Shi, Y.; Kurz, S.; Hu, J.; Wang, L.; Shao, J.; Atzberger, A. et al.; Wang, Z.; Wang, C.; Zang, W.; Fleming, I.; Wettschureck, N.; Honore, E.; Offermanns, S.: Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. NATURE COMMUNICATIONS 11 (1) (2020)

Iring, A.; Jin, Y.-J.; Albarran-Juarez, J.; Siragusa, M.; Wang, S.; Dancs, P. T.; Nakayama, A.; Tonack, S.; Chen, M.; Kuenne, C. et al.; Sokol, A. M.; Guenther, S.; Martinez, A.; Fleming, I.; Wettschureck, N.; Graumann, J.; Weinstein, L. S.; Offermanns, S.: Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure. JOURNAL OF CLINICAL INVESTIGATION 129 (7), pp. 2775 - 2791 (2019)

Schuermann, C.; Dienst, F. L.; Palfi, K.; Vasconez, A. E.; Oo, J. A.; Wang, S.; Buchmann, G. K.; Offermanns, S.; van de Sluis, B.; Leisegang, M. S. et al.; Guenther, S.; Humbert, P. O.; Lee, E.; Zhu, J.; Weigert, A.; Mathoor, P.; Wittig, I.; Kruse, C.; Brandes, R. P.: The polarity protein Scrib limits atherosclerosis development in mice. CARDIOVASCULAR RESEARCH 115 (14), pp. 1963 - 1974 (2019)

Yin, W.; Kim, H.-T.; Wang, S.; Gunawan, F.; Li, R.; Buettner, C.; Grohmann, B.; Sengle, G.; Sinner, D.; Offermanns, S. et al.; Stainier, D. Y. R.: Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis. EUROPEAN RESPIRATORY JOURNAL 53 (3), 1800840 (2019)