Max Planck Institute for Heart and Lung Research - W. G. Kerckhoff Institute
Key Publications (since 2008)
Li R, Shao J, Jin YJ, Kawase H, Ong YT, Troidl K, Quan Q, Wang L, Bonnavion R, Wietelmann A, Helmbacher F, Potente M, Graumann J, Wettschureck N, Offermanns S. (2023) Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2. Nat. Commun. 14, 1980.
Nakayama A, Roquid KA, Iring A, Strilic B, Günther S, Chen M, Weinstein LS, Offermanns S. (2023) Suppression of CCL2 angiocrine function by adrenomedullin promotes tumor growth. J. Exp. Med. 220, e20211628.
Liang G, Wang S, Shao J, Jin Y, Xu L, Yan Y, Günther S, Wang L, Offermanns S. (2022) Tenascin-X Mediates Flow-Induced Suppression of EndMT and Atherosclerosis. Circ Res. 130, 1647-1659.
Wang S, Wang B, Shi Y, Möller T, Stegmeyer RI, Strilic B, Li T, Yuan Z, Wang C, Wettschureck N, Vestweber D, Offermanns S. (2022) Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis. Blood. 140, 171-183.
Gurusamy M, Tischner D, Shao J, Klatt S, Zukunft S, Bonnavion R, Günther S, Siebenbrodt K, Kestner RI, Kuhlmann T, Fleming I, Offermanns S, Wettschureck N. (2021) G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators. Nat Commun. 12, 6798
Jin YJ, Chennupati R, Li R, Liang G, Wang S, Iring A, Graumann J, Wettschureck N, Offermanns S. (2021) Protein kinase N2 mediates flow-induced eNOS activation and vascular tone regulation. J Clin Invest. 131, e145734
Le Mercier A, Bonnavion R, Yu W, Alnouri MW, Ramas S, Zhang Y, Jäger Y, Roquid KA, Jeong HW, Sivaraj KK, Cho H, Chen X, Strilic B, Sijmonsma T, Ralf Adams R, Schroeder T, Rieger MA, Offermanns S. (2021) GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis. Proc Natl Acad Sci USA. 118, e2021596118
Carvalho J, Chennupati R, Li R, Günther S, Kaur H, Zhao W, Tonack S, Kurz M, Mößlein N, Bünemann M, Offermanns S, Wettschureck N. (2020) Orphan G-Protein-Coupled Receptor GPRC5B Controls Smooth Muscle Contractility and Differentiation by Inhibiting Prostacyclin Receptor Signaling. Circulation. 141, 1168-1183
Wang L, Wang S, Shi Y, Li R, Günther S, Yuan Z, Liu E, Offermanns S (2020) YAP and TAZ protect against white adipocyte cell death during obesity. Nat Commun. 11, 5455
Wang S, Cao S, Arhatte M, Li D, Shi Y, Kurz S, Hu J, Wang L, Shao J, Atzberger A, Wang Z, Wang C, Zang W, Fleming I, Wettschureck N, Honoré E, Offermanns S. (2020) Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. Nat Commun. 11, 2303
Iring A, Jin YJ, Albarrán-Juárez J, Siragusa M, Wang S, Dancs PT, Nakayama A, Tonack S, Chen M, Künne C, Sokol AM, Günther S, Martínez A, Fleming I, Wettschureck N, Graumann J, Weinstein LS, Offermanns S. (2019) Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure. J Clin Invest. 129, 2775-2791
Wettschureck N, Strilic B, Offermanns S (2019) Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation. Physiol Rev. 99, 1467-1525
Albarrán-Juárez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, Wettschureck N, Althoff TF, Offermanns S. (2018) Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation. J Exp Med. 215, 2655-2672
Tunaru S, Bonnavion R, Brandenburger I, Preussner J, Thomas D, Scholich K, Offermanns S. (2018) 20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1. Nat Commun. 9, 177
Kaur H, Carvalho J, Looso M, Singh P, Chennupati R, Preussner J, Günther S, Albarrán-Juárez J, Tischner D, Classen S, Offermanns S, Wettschureck N. (2017) Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system. Nat Commun. 8,15700
Sassmann-Schweda A, Singh P, Tang C, Wietelmann A, Wettschureck N, Offermanns S (2016) Increased apoptosis and browning of TAK1-deficient adipocytes protects agains obesity. JCI Insight 1: e81175
Strilic B, Yang L, Albarrán-Juárez J, Wachsmuth L, Han K, Müller UC, Pasparakis M, Offermanns S. (2016) Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature. 536, 215-218
Wang SP, Chennupati R, Iring A, Kaur H, Wettschureck N, Offermanns S. (2016) Endothelial Piezo1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest. 126, 4527-4536
Offermanns S, Schwaninger M. (2015) Nutritional or pharmacological activation of HCA2 ameliorates neuroinflammation. Trends Mol. Med. 21, 245-255
Tang C, Ahmed K, Gille A, Lu S, Gröne HJ, Tunaru S, Offermanns S (2015). Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes. Nat. Med. 21, 173-177
Wang S, Iring A, Strilic B, Albarrán Juárez J, Kaur H, Troidl K, Tonack S, Burbiel JC, Müller CE, Fleming I, Lundberg JO, Wettschureck N, Offermanns S (2015). P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction. J. Clin. Invest. 125, 3077-3086
Chen H, Assmann JC, Krenz A, Rahman M, Grimm M, Karsten CM, Köhl J, Offermanns S, Wettschureck N, Schwaninger M. (2014) Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE. J Clin Invest. 124, 2188-2192
Offermanns S. (2014) Free Fatty Acid (FFA) and Hydroxy Carboxylic Acid (HCA) Receptors. Annu Rev Pharmacol Toxicol. 54, 407-34
Worzfeld T, Swiercz JM, Sentürk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chan AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S. (2014) Genetic dissection of plexin signaling in vivo. Proc Natl Acad Sci U S A. 111, 2194-2199
Schumacher D, Strilic B, Sivaraj KK, Wettschureck N, Offermanns S. (2013) Platelet-derived nucleoides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor. Cancer Cell 24, 130-137
Sivaraj KK, Takefuji M, Schmidt I, Adams R, Offermanns S, Wettschureck N. (2013) G13 controls angiogenesis through regulation of VEGFR-2 expression. Dev Cell 25, 427-34
Takefuji M Krüger M, Sivaraj KK, Kaibuchi K, Offermanns S, Wettschureck N. (2013) RhoGEF12 controls cardiac remodeling by integrating G-protein- and integrin-dependent signaling cascades. J Exp Med 210:665-73
Althoff TF, Albarrán Juárez J, Troidl K, Tang C, Wang S, Wirth A, Takefuji M, Wettschureck N, Offermanns S (2012) Procontractile G-protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling. J. Exp. Med. 209, 2277-90
Blad CC, Tang C, Offermanns S (2012) G protein-coupled receptors for energy metabolites as new therapeutic targets. Nat. Rev. Drug. Discov. 11, 601-619
Tunaru S, Althoff TF, Nusing RM, Diener M, Offermanns S (2012) Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. Proc Natl Acad Sci U S A 109, 9179-9184
Worzfeld T, Swiercz JM, Looso M, Straub BK, Sivaraj KK, Offermanns S (2012) ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis. J Clin Invest 122, 3296-2305
Lukasova M, Malaval C, Gille A, Kero J, Offermanns S (2011a) Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. J Clin Invest 121, 1163-1173
Lukasova M, Hanson J, Tunaru S, Offermanns S (2011b) Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potential. Trends Pharmacol Sci 32, 700-707
Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, Ijzerman AP (2011) International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B). Pharmacol Rev 63, 269-290
Ahmed, K., Tunaru, S., Tang, C., Müller, M., Gille, A., Sassmann, A., Hanson, J., and Offermanns, S. (2010) An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Cell Metab. 11, 311-19
Hanson J, Gille A, Zwykiel S, Lukasova M, Clausen BE, Ahmed K, Tunaru S, Wirth A, Offermanns S. (2010) Keratinocytes express GPR109A and mediate epidermal effects of nicotinic acid and mono-Methyl fumarate via COX-2-dependent prostanoid formation J. Clin. Invest. 120, 2910-2919
Sassmann A, Gier B, Gröne HJ, Drews G, Offermanns S, Wettschureck N. (2010) The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion J. Clin. Invest. 120, 2184-2193
Ahmed K, Tunaru S, Langhans CD, Hanson J, Michalski CW, Kölker S, Jones PM, Okun JG, Offermanns S. (2009) Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis. J Biol Chem. 284, 21928-33
Herroeder S, Reichardt P, Sassmann A, Zimmermann B, Jaeneke D, Hoeckner J, Hollmann MW, Fischer KD, Vogt S, Grosse R, Hogg N, Gunzer M, Offermanns S, Wettschureck N. (2009) Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility. Immunity 30, 708-720
Korhonen H, Fisslthaler B, Moers A, Wirth A, Habermehl D, Wieland T, Schütz G, Wettschureck N, Fleming I, Offermanns S. (2009) Anaphylactic shock depends on endothelial Gq/G11. J Exp Med, 206, 411-420
Gille A, Bodor ET, Ahmed K, Offermanns S. (2008) Nicotinic acid: Pharmacological effects and mechanisms of action. Annu Rev Pharmacol Toxicol 48, 79-106
Wirth A, Benyó Z, Lukasova M, Leutgeb B, Wettschureck N, Gorbey S, Őrsy P, Horváth B, Maser-Gluth C, Greiner E, Lemmer B, Schütz G, Gutkind S, Offermanns S. (2008) G12/G13-LARG-mediated signalling in vascular smooth muscle is required for salt-induced hypertension. Nat Med 14, 64-68
Worzfeld, T, Wettschureck, N, Offermanns S. (2008) G(12)/G(13)-mediated signalling in mammalian physiology and disease. Trends Pharmacol. Sci. 29, 582-589