Publikationen von Mario Looso

Hofmann, T.; Hettrich, S.; Idrissou, B. M. G.; Waechter, C.; Weiss, M.; Hachim, S.; Kreher, S.; Staps, M.; Canes Esteve, L.; Pankuweit, S. et al.; Milting, H.; Looso, M.; Marty, I.; Engelhardt, S.; Braun, T.; Boettger, T.: Trdn-as directs m6A-dependent transcriptional termination for accurate triadin isoform switching, preventing aberrant dyads and cardiomyopathy cardiomyopathy. NATURE COMMUNICATIONS 17 (1), 7269 (2026)

Walter, J.; Kuenne, C.; Knoppik, N.; Goymann, P.; Looso, M.: FRED enables standardized FAIR metadata generation and management for omics research. SCIENTIFIC REPORTS 16 (1), 23202 (2026)

Schultheis, H.; Detleffsen, J.; Wiegandt, R.; Bentsen, M.; Alayoubi, Y.; Valente, G.; Kessler, M. F.; Bruns, B.; Mirza, D.; Usanayo, A. et al.; Mueller, K.; Walter, J.; Goymann, P.; Hobein, M.; Kuenne, C.; Looso, M.: SC-framework: A robust and FAIR semi-interactive environment for single-cell resolution datasets. ISCIENCE 29 (7), 116631 (2026)

Candlish, M.; Hofmann, J.; Brosamle, D.; Haessler, A.; DeMeglio, M.; Skodras, A.; Tushev, G.; De Biasi, E. S.; Gunther, S.; Wiegandt, R. et al.; Theis, H.; De Domenico, E.; Hermann, N. S.; Breunig, P.; Sauerland, C.; Nilsson, K. P. R.; Beyer, M. D.; Looso, M.; Windbergs, M.; Roeber, S.; Herms, J.; Neher, J. J.; Chiocchetti, A. G.; Hefendehl, J. K.: Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology. JOURNAL OF NEUROINFLAMMATION 23 (1), 213 (2026)

Siragusa, M.; Graumann, J.; Kuenne, C.; Gunther, S.; Jeratsch, S.; Guven, B.; Susser, S.; Talyan, S.; Bezuneh, B.; Matthess, Y. et al.; Cartura, M.; Zhou, X.; Cho, H.; Sachs, N.; Maegdefessel, L.; Muller, O. J.; Troidl, C.; Nef, H. M.; Looso, M.; Kaulich, M.; Offermanns, S.; Fleming, I.: Identification of unannotated microproteins involved in endothelial cell homeostasis, dysfunction, and vascular disease. CARDIOVASCULAR RESEARCH (2026)

Thurner, L.; Fadle, N.; Thurner, B.; Kos, I. A.; Bewarder, M.; Regitz, E.; Bette, B.; Fischer, Y.; Lesan, V.; Rixecker, T. et al.; Hoffmann, M.-C.; Preuss, K.-D.; Schormann, C.; Kaddu-Mulindwa, D.; Roemer, K.; Cetin, O.; Mang, S.; Becker, A.; Seiler, F.; Herr, C.; Lensch, C.; Lehmann, J.; Thiel-Bodenstaff, A.; Link, A.; Werner, C.; Wuchter, P.; Korper, S.; Pfuhl, T.; Lohse, S.; Rissland, J.; Thieser, K.; Pilch, J.; Papan, C.; Roth, S.; Vehreschild, J. J.; Scherer, M.; Brohl, I.; Wagner, P.; Witzenrath, M.; Thibeault, C.; Haack, I. a.; Mitrov, L.; Putz, S. M.; Reese, J.-P.; Krawczak, M.; Hamelmann, E.; Kopfnagel, V.; Fiedler, K.; Geisler, R.; Valentin, H.; Stahl, D.; Hanss, S.; Ameling, S.; Volker, U.; Hansch, S.; Dorr, M.; Blaschke, S.; Braunsteiner, J.; Dahl, E.; Pape, D.; Petersmann, A.; Stilgenbauer, S.; Bloos, F.; Schrezenmeier, H.; Langer, F.; Gabelein, G.; Friesenhahn-Ochs, B.; Pfeifer, J.; Bauer, M.; Becker, S. L.; Neumann, F.; Bohm, M.; Anton, G.; Kuenne, C.; Pullamsetti, S. S.; Looso, M.; Bals, R.; Smola, S.; Meybohm, P.; Krawczyk, M.; Lepper, P. M.; Kessel, C.: Autoantibodies to IL-1Ra and PGRN in severe COVID-19 are associated with inflammation-induced hyperphosphorylated antigen isoforms. NATURE COMMUNICATIONS 17 (1), 4768 (2026)

Kawase, H.; Liu, S.; Kurz, S.; Bengelsdorff, V.; Bonnavion, R.; Jin, Y.-J.; Roquid, K. A.; Cho, H.; Liang, G.; Banicevic, M. et al.; Shiva, N.; Yunes-Leites, P. S.; Gunther, S.; Tombor, L.; Dimmeler, S.; Looso, M.; Mattonet, K.; Wettschureck, N.; Muller, U. C.; Offermanns, S.: Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis. SCIENCE ADVANCES 12 (21), eaeh0301 (2026)

Tarasco, M.; Juan, T.; Alayoubi, Y.; Kulkarni, R.; Schumann, A.; da Silva, A. R.; Albu, M.; Dwari, M.; Dlnija, M.; Gunther, S. et al.; Looso, M.; Stainier, D. Y. R.: Time-resolved single-cell transcriptomics maps zebrafish heart development. CELL REPORTS 45 (4), 117249 (2026)

Malainou, C.; Peteranderl, C.; Ferrero, M. R.; Vazquez-Armendariz, A. I.; Alexopoulos, I.; Franz, K.; Knippenberg, K.; Better, J.; Estiri, M.; Wu, C.-Y. et al.; Schultheis, H.; Bushe, J.; del Rio, M.-L.; Rodriguez-Barbosa, J. I.; Pfeffer, K.; Gunther, S.; Looso, M.; Gruber, A. D.; Vadasz, I.; Matt, U.; Herold, S.: TNF superfamily member 14 drives post-influenza depletion of alveolar macrophages, enabling secondary pneumococcal pneumonia. JOURNAL OF CLINICAL INVESTIGATION 136 (2), e185390 (2026)

Leberzammer, J.; Abplanalp, W. T.; Grikscheit, K.; Solomonidis, E. G.; Glaser, S.-F.; Schuhmacher, B.; Merten, M.; Jeremijev, G.; Wilken-Schmitz, A.; Korth, L. et al.; John, D.; Gunther, S.; Kuenne, C.; Looso, M.; Valasarajan, C.; Benes, V.; Jung, F.; Niehaus, V.; Anton, G.; Stellbrink, C.; Rommele, C.; Gopel, S.; Pullamsetti, S. S.; Vehreschild, J.; Vehreschild, M.; Ciesek, S.; Leistner, D. M.; Zeiher, A. M.; Dimmeler, S.; Cremer, S.: Atherosclerosis licenses for an exceeding immune response in COVID-19 disease by interferon priming in circulating myeloid cells. CARDIOVASCULAR RESEARCH (2026)

Dizdarevic, S.; Wiegandt, R.; Weigert, A.; Stiewe, T.; Eul, B.; Guenther, S.; Grimminger, F.; Seeger, W.; Pullamsetti, S. S.; Looso, M. et al.; Turkowski, K.; Savai, R.: Divergent CD45+ immune landscapes shape the lung tumor microenvironment. FRONTIERS IN IMMUNOLOGY 17, 1765833 (2026)

Drekolia, M.-K.; Mettner, J.; Wang, D.; Lagos, F. D.; Koch, C.; Hecker, D.; Eresch, J.; Mao, Y.; Bahr, M.; Weichenhan, D. et al.; Cordero, J.; Wittig, J.; Zhang, B.; Cui, H.; Li, X.; Oo, J. A.; Weigert, A.; Siragusa, M.; Klatt, S.; Fleming, I.; Gunther, S.; Looso, M.; Brandes, R. P.; Langer, H. F.; Papapetropoulos, A.; Singhal, M.; Schulz, M. H.; Plass, C.; Heineke, J.; Dobreva, G.; Hu, J.; Bibli, S.-I.: Cystine import and oxidative catabolism fuel vascular growth and repair via nutrient-responsive histone acetylation. CELL METABOLISM 38 (1) (2026)

Roquid, K. A.; Vucetic, A.; Dyukova, E.; Hanssen , M. J.; Cho, H.; Bonnavion, R.; Mattonet, K.; Looso, M.; Sanda, M.; Strilic, B. et al.; Offermanns, S.: Lung endothelial PEAR1 induces tumor cell dormancy. MOLECULAR CANCER 24 (1), 278 (2025)

Jan, D.; Brenton, B.; Bentsen, M.; Kuenne, C.; Looso, M.: PEAKQC: periodicity evaluation in single-cell ATAC-seq data for quality assessment. BRIEFINGS IN BIOINFORMATICS 26 (5), bbaf465 (2025)

Panza, P.; Kim, H.-T.; Lautenschlaeger, T.; Piesker, J.; Guenther, S.; Alayoubi, Y.; Cleaver, O.; Looso, M.; Stainier, D. Y. R.: The lung microvasculature promotes alveolar type 2 cell differentiation via secreted SPARCL1. STEM CELL REPORTS 20 (4), 102451 (2025)

Gupta, S.; Bajwa, G. K.; El-Sammak, H.; Mattonet, K.; Guenther, S.; Looso, M.; Stainier, D. Y. R.; Marin-Juez, R.: The transmembrane glycoprotein Gpnmb is required for the immune and fibrotic responses during zebrafish heart regeneration. DEVELOPMENTAL BIOLOGY 521, S. 153 - 162 (2025)

Cho, H.; Lai, C.-C.; Bonnavion, R.; Alnouri, M. W.; Wang, S.; Roquid, K. A.; Kawase, H.; Campos, D.; Chen, M.; Weinstein, L. S. et al.; Martinez, A.; Looso, M.; Sanda, M.; Offermanns, S.: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. SCIENCE 387 (6734), S. 674 - 682 (2025)

Cho, H.; Lai, C.-C.; Bonnavion, R.; Alnouri, M. W.; Wang, S.; Roquid, K. A.; Kawase, H.; Campos, D.; Chen, M.; Weinstein, L. S. et al.; Martinez, A.; Looso, M.; Sanda, M.; Offermanns, S.: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. SCIENCE 387 (6734), S. 674 - 682 (2025)

Xu, Y.; Gehlot, R.; Capon, S. J.; Albu, P. M.; Gretz, J.; Bloomekatz, J.; Mattonet, K.; Vucicevic, D.; Talyan, S.; Kikhi, K. et al.; Guenther, S.; Looso, M.; Firulli, B. A.; Sanda, M.; Firulli, A. B.; Lacadie, S. A.; Yelon, D.; Stainier, D. Y. R.: PDGFRA is a conserved HAND2 effector during early cardiac development. NATURE CARDIOVASCULAR RESEARCH 3 (12) (2024)

Xu, Y.; Gehlot, R.; Capon, S. J.; Albu, M.; Gretz, J.; Bloomekatz, J.; Mattonet, K.; Vucicevic, D.; Talyan, S.; Kikhi, K. et al.; Guenther, S.; Looso, M.; Firulli, B. A.; Sanda, M.; Firulli, A. B.; Lacadie, S. A.; Yelon, D.; Stainier, D. Y. R.: PDGFRA is a conserved HAND2 effector during early cardiac development. NATURE CARDIOVASCULAR RESEARCH 3 (12) (2024)