Publications of Rajkumar Savai

Sommer, N.; Theine, F. F.; Pak, O.; Tello, K.; Richter, M.; Gall, H.; Wilhelm, J.; Savai, R.; Weissmann, N.; Seeger, W. et al.; Ghofrani, H. A.; Hecker, M.: Mitochondrial Respiration in Peripheral Blood Mononuclear Cells Negatively Correlates with Disease Severity in Pulmonary Arterial Hypertension. JOURNAL OF CLINICAL MEDICINE 11 (14), 4132 (2022)

Kuhnert, S.; Mansouri, S.; Rieger, M. A.; Savai, R.; Avci, E.; Diaz-Pina, G.; Padmasekar, M.; Looso, M.; Hadzic, S.; Acker, T. et al.; Klatt, S.; Wilhelm, J.; Fleming, I.; Sommer, N.; Weissmann, N.; Vogelmeier, C.; Bals, R.; Zeiher, A.; Dimmeler, S.; Seeger, W.; Pullamsetti, S. S.: Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD. CELLS 11 (13), 2121 (2022)

Chelladurai, P.; Kuenne, C.; Bourgeois, A.; Guenther, S.; Valasarajan, C.; Cherian V, A.; Rottier, R. J.; Romanet, C.; Weigert, A.; Boucherat, O. et al.; Eichstaedt, C. A.; Ruppert, C.; Guenther, A.; Braun, T.; Looso, M.; Savai, R.; Seeger, W.; Bauer, U.-M.; Bonnet, S.; Pullamsetti, S. S.: Epigenetic reactivation of transcriptional programs orchestrating fetal lung development in human pulmonary hypertension. SCIENCE TRANSLATIONAL MEDICINE 14 (648), eabe5407 (2022)

Kandra, P.; Nandigama, R.; Eul, B.; Huber, M.; Kobold, S.; Seeger, W.; Grimminger, F.; Savai, R.: Utility and Drawbacks of Chimeric Antigen Receptor T Cell (CAR-T) Therapy in Lung Cancer. FRONTIERS IN IMMUNOLOGY 13, 903562 (2022)

Sekar, D.; Dillmann, C.; Sirait-Fischer, E.; Fink, A. F.; Zivkovic, A.; Baum, N.; Strack, E.; Klatt, S.; Zukunft, S.; Wallner, S. et al.; Descot, A.; Olesch, C.; da Silva, P.; von Knethen, A.; Schmid, T.; Groesch, S.; Savai, R.; Ferreiros, N.; Fleming, I.; Ghosh, S.; Rothlin V, C.; Stark, H.; Medyouf, H.; Bruene, B.; Weigert, A.: Phosphatidylserine Synthase PTDSS1 Shapes the Tumor Lipidome to Maintain Tumor-Promoting Inflammation. CANCER RESEARCH 82 (8), pp. 1617 - 1632 (2022)

Elwakeel, E.; Brueggemann, M.; Wagih, J.; Lityagina, O.; Elewa, M. A. F.; Han, Y.; Froemel, T.; Popp, R.; Nicolas, A. M.; Schreiber, Y. et al.; Gradhand, E.; Thomas, D.; Nuesing, R.; Steinmetz-Spaeh, J.; Savai, R.; Fokas, E.; Fleming, I.; Greten, F. R.; Zarnack, K.; Bruene, B.; Weigert, A.: Disruption of Prostaglandin E2 Signaling in Cancer-Associated Fibroblasts Limits Mammary Carcinoma Growth but Promotes Metastasis. CANCER RESEARCH 82 (7), pp. 1380 - 1395 (2022)

Gredic, M.; Wu, C.-Y.; Hadzic, S.; Pak, O.; Savai, R.; Kojonazarov, B.; Doswada, S.; Weiss, A.; Weigert, A.; Guenther, A. et al.; Brandes, R. P.; Schermuly, R. T.; Grimminger, F.; Seeger, W.; Sommer, N.; Kraut, S.; Weissmann, N.: Myeloid-cell-specific deletion of inducible nitric oxide synthase protects against smoke-induced pulmonary hypertension in mice. EUROPEAN RESPIRATORY JOURNAL 59 (4), 2101153 (2022)

Hirani, D.; Alvira, C. M.; Danopoulos, S.; Milla, C.; Donato, M.; Tian, L.; Mohr, J.; Dinger, K.; Vohlen, C.; Selle, J. et al.; Koningsbruggen-Rietschel V, S.; Barbarino, V.; Pallasch, C.; Rose-John, S.; Odenthal, M.; Pryhuber, G. S.; Mansouri, S.; Savai, R.; Seeger, W.; Khatri, P.; Al Alam, D.; Doetsch, J.; Alcazar, M. A. A.: Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia. EUROPEAN RESPIRATORY JOURNAL 59 (2), 2002248 (2022)

Olesch, C.; Brunn, D.; Aktay-Cetin, O.; Sirait-Fischer, E.; Pullamsetti, S. S.; Grimminger, F.; Seeger, W.; Bruene, B.; Weigert, A.; Savai, R.: Picturing of the Lung Tumor Cellular Composition by Multispectral Flow Cytometry. FRONTIERS IN IMMUNOLOGY 13, 827719 (2022)

Avci, E.; Sarvari, P.; Savai, R.; Seeger, W.; Pullamsetti, S. S.: Epigenetic Mechanisms in Parenchymal Lung Diseases: Bystanders or Therapeutic Targets? INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 (1), 546 (2022)

Rajpoot, S.; Solanki, K.; Kumar, A.; Zhang, K. Y. J.; Pullamsetti, S. S.; Savai, R.; Faisal, S. M.; Pan, Q.; Baig, M. S.: In-Silico Design of a Novel Tridecapeptide Targeting Spike Protein of SARS-CoV-2 Variants of Concern. INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS 28 (1), 28 (2021)

Berghausen, E. M.; Janssen, W.; Vantler, M.; Gnatzy-Feik, L. L.; Krause, M.; Behringer, A.; Joseph, C.; Zierden, M.; ten Freyhaus, H.; Klinke, A. et al.; Baldus, S.; Alcazar, M. A.; Savai, R.; Pullamsetti, S. S.; Wong, D. W. L.; Boor, P.; Zhao, J. J.; Schermuly, R. T.; Rosenkranz, S.: Disrupted PI3K subunit p110 alpha signaling protects against pulmonary hypertension and reverses established disease in rodents. JOURNAL OF CLINICAL INVESTIGATION 131 (19), e136939 (2021)

Donzelli, J.; Proestler, E.; Riedel, A.; Nevermann, S.; Hertel, B.; Guenther, A.; Gattenloehner, S.; Savai, R.; Larsson, K.; Saul, M. J.: Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer. JOURNAL OF EXTRACELLULAR VESICLES 10 (12), 12143 (2021)

Karger, A.; Nandigama, R.; Stenzinger, A.; Grimminger, F.; Pullamsetti, S. S.; Seeger, W.; Savai, R.: Hidden Treasures: Macrophage Long Non-Coding RNAs in Lung Cancer Progression. CANCERS 13 (16), 4127 (2021)

Padmasekar, M.; Savai, R.; Seeger, W.; Pullamsetti, S. S.: Exposomes to Exosomes: Exosomes as Tools to Study Epigenetic Adaptive Mechanisms in High-Altitude Humans. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 18 (16), 8280 (2021)

Eichhorn, F.; Klotz V, L.; Kriegsmann, M.; Bischoff, H.; Schneider, M. A.; Muley, T.; Kriegsmann, K.; Haberkorn, U.; Heussel, C. P.; Savai, R. et al.; Zoernig, I.; Jaeger, D.; Thomas, M.; Hoffmann, H.; Winter, H.; Eichhorn, M. E.: Neoadjuvant anti-programmed death-1 immunotherapy by pembrolizumab in resectable non-small cell lung cancer: First clinical experience. LUNG CANCER 153, pp. 150 - 157 (2021)

Brunn, D.; Turkowski, K.; Gunther, S.; Weigert, A.; Muley, T.; Kriegsmann, M.; Winter, H.; Dammann, R. H.; Stathopoulos, G. T.; Thomas, M. et al.; Guenther, A.; Grimminger, F.; Pullamsetti, S. S.; Seeger, W.; Savai, R.: Interferon Regulatory Factor 9 Promotes Lung Cancer Progression via Regulation of Versican. CANCERS 13 (2), 208 (2021)

Fink, C.; Baal, N.; Wilhelm, J.; Sarode, P.; Weigel, R.; Schumacher, V.; Nettersheim, D.; Schorle, H.; Schroeck, C.; Bergmann, M. et al.; Kliesch, S.; Kressin, M.; Savai, R.: On the origin of germ cell neoplasia in situ: Dedifferentiation of human adult Sertoli cells in cross talk with seminoma cells in vitro *. NEOPLASIA 23 (7), pp. 731 - 742 (2021)

Strack, E.; Rolfe, P. A.; Fink, A. F.; Bankov, K.; Schmid, T.; Solbach, C.; Savai, R.; Sha, W.; Pradel, L.; Hartmann, S. et al.; Bruene, B.; Weigert, A.: Identification of tumor-associated macrophage subsets that are associated with breast cancer prognosis. CLINICAL AND TRANSLATIONAL MEDICINE 10 (8), e239 (2020)

Kuester, M. M.; Schneider, M. A.; Richter, A. M.; Richtmann, S.; Winter, H.; Kriegsmann, M.; Pullamsetti, S. S.; Stiewe, T.; Savai, R.; Muley, T. et al.; Dammann, R. H.: Epigenetic Inactivation of the Tumor Suppressor IRX1 Occurs Frequently in Lung Adenocarcinoma and Its Silencing Is Associated with Impaired Prognosis. CANCERS 12 (12), 3528 (2020)