During the lifetime of an organism the cardiovascular system undergoes various adaptive changes in response to physiological cues. These changes reflect the need of an organism to maintain sufficient circulation at all costs. Most often adaption guarantees proper functioning of the cardiovascular system but at certain occasion adaption derails and acquires pathological qualities. A circulus vitiosus might develop, which causes more harm than the original cause. Adaption in the myocardium secondary to myocardial infarction (MI) and/or arterial hypertension often leads to cardiac remodeling, a rearrangement of normally existing structures, which allows both the myocyte and the collagen network to adaptto new working conditions.