Publications

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*co-corresponding authors

 

Repression of Osmr and Fgfr1 by miR-1/133a prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart.
Valussi M, Besser J, Wystub-Lis K, Zukunft S, Richter M, Kubin T, Boettger T*, Braun T*.
Sci Adv. 2021 Oct 15;7(42):eabi6648. doi: 10.1126/sciadv.abi6648. Epub 2021 Oct 13.
 PMID: 34644107

BMP9 and BMP10 act directly on vascular smooth muscle cells for generation and maintenance of the contractile state.
Wang L, Rice M, Swist S, Kubin T, Wu F, Wang S, Kraut S, Weissmann N, Böttger T, Wheeler M, Schneider A, Braun T
Circulation. 2021 Apr 6;143(14):1394-1410. doi: 10.1161/CIRCULATIONAHA.120.047375. PMID: 33334130

Linc-MYH configures INO80 to regulate muscle stem cell numbers and skeletal muscle hypertrophy.
Schutt C, Hallmann A, Hachim S, Klockner I, Valussi M, Atzberger A, Graumann J, Braun T*, Boettger T*.
EMBO J. 2020 Nov 16;39(22):e105098. doi: 10.15252/embj.2020105098.
PMID: 32960481

Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome.
Li M, Nishio SY, Naruse C, Riddell M, Sapski S, Katsuno T, Hikita T, Mizapourshafiyi F, Smith FM, Cooper LT, Lee MG, Asano M, Boettger T, Krueger M, Wietelmann A, Graumann J, Day BW, Boyd AW, Offermanns S, Kitajiri SI, Usami SI, Nakayama M.
Nat Commun. 2020 Mar 12;11(1):1343. doi: 10.1038/s41467-020-15198-9. PMID: 32165640

RASSF10 Is Frequently Epigenetically Inactivated in Kidney Cancer and Its Knockout Promotes Neoplasia in Cancer Prone Mice.
Richter AM, Woods ML, Küster MM, Walesch SK, Braun T, Boettger T, Dammann RH.
Oncogene. 2020 Feb 11. doi: 10.1038/s41388-020-1195-6. [Epub ahead of print]. PMID: 32047266

Epigenetic therapy of novel tumour suppressor ZAR1 and its cancer biomarker function.
Deutschmeyer V, Breuer J, Walesch SK, Sokol AM, Graumann J, Bartkuhn M, Boettger T, Rossbach O, Richter AM.
Clin Epigenetics. 2019 Dec 4;11(1):182. doi: 10.1186/s13148-019-0774-2. PMID: 31801617

Exploration of physiological and pathophysiological implications of miRNA-143 and miRNA-145 in cerebral arteries.
Christensen ST, Johansson SE, Warfvinge K, Braun T, Boettger T, Edvinsson L, Haanes KA.
J Cardiovasc Pharmacol. 2019 Aug 13. doi: 10.1097/FJC.0000000000000735. PMID: 31425342

Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET.
Jia Y, Vong JS, Asafova A, Garvalov BK, Caputo L, Cordero J, Singh A, Boettger T, Günther S, Fink L, Acker T, Barreto G, Seeger W, Braun T, Savai R, Dobreva G.
J Exp Med. 2019 Jun 3;216(6):1377-1395. doi: 10.1084/jem.20181394.; PMID: 31015297

Deubiquitinase USP10 regulates Notch signaling in the endothelium.
Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JWD, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I, Potente M.
Science. 2019 Apr 12;364(6436):188-193. doi: 10.1126/science.aat0778. PMID: 30975888

Choice of binding sites for CTCFL compared to CTCF is driven by chromatin and by sequence preference.
Bergmaier P, Weth O, Dienstbach S, Boettger T, Galjart N, Mernberger M, Bartkuhn M, Renkawitz R.
Nucleic Acids Res. 2018 Aug 21;46(14):7097-7107. doi: 10.1093/nar/gky483. PMID: 29860503

Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster.
Wüst S, Dröse S, Heidler J, Wittig I, Klockner I, Franko A, Bonke E, Günther S, Gärtner U, Boettger T*, Braun T*.
Cell Metab. 2018 May 1;27(5):1026-1039.e6. doi: 10.1016/j.cmet.2018.02.022. Epub 2018 Apr 5.
PMID: 29606596

Loss of Vascular Myogenic Tone in miR-143/145 Knockout Mice Is Associated With Hypertension-Induced Vascular Lesions in Small Mesenteric Arteries.
Holmberg J, Bhattachariya A, Alajbegovic A, Rippe C, Ekman M, Dahan D, Hien TT, Boettger T, Braun T, Swärd K, Hellstrand P, Albinsson S.
Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):414-424. doi: 10.1161/ATVBAHA.117.310499. PMID: 29217510

The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells.
Kespohl M, Vachharajani N, Luu M, Harb H, Pautz S, Wolff S, Sillner N, Walker A, Schmitt-Kopplin P, Boettger T, Renz H, Offermanns S, Steinhoff U, Visekruna A.
Front Immunol. 2017 Aug 28;8:1036. doi: 10.3389/fimmu.2017.01036. eCollection 2017. PMID: 28894447

Factor VII activating protease (FSAP) regulates the expression of inflammatory genes in vascular smooth muscle and endothelial cells.
Byskov K, Boettger T, Ruehle PF, Nielsen NV, Etscheid M, Kanse SM.
Atherosclerosis. 2017 Aug 25;265:133-139. doi: 10.1016/j.atherosclerosis.2017.08.029. PMID: 28881271

MicroRNA-Dependent Control of Serotonin-Induced Pulmonary Arterial Contraction.
Dahan D, Hien TT, Tannenberg P, Ekman M, Rippe C, Boettger T, Braun T, Tran-Lundmark K, Tran PK, Swärd K, Albinsson S.
J Vasc Res. 2017 Aug 11;54(4):246-256. doi: 10.1159/000478013. PMID: 28796998

The tumor suppressor RASSF1A induces the YAP1 target gene ANKRD1 that is epigenetically inactivated in human cancers and inhibits tumor growth.
Jiménez AP, Traum A, Boettger T, Hackstein H, Richter AM, Dammann RH.
Oncotarget. 2017 May 23. doi: 10.18632/oncotarget.18177. PMID: 28596500

Sex-specific, reciprocal regulation of ERα and miR-22 controls muscle lipid metabolism in male mice.
Schweisgut J, Schutt C, Wüst S, Wietelmann A, Ghesquière B, Carmeliet P, Dröse S, Korach KS, Braun T*, Boettger T*.
EMBO J. 2017 May 2;36(9):1199-1214. doi: 10.15252/embj.201695988.
PMID: 28314781

tBRD-1 and tBRD-2 regulate expression of genes necessary for spermatid differentiation.
Theofel I, Bartkuhn M, Boettger T, Gartner SM, Kreher J, Brehm A, Rathke C.
Biol Open. 2017 Apr 15;6(4):439-448. doi: 10.1242/bio.022467. PMID: 28235844

Elevated glucose levels promote contractile and cytoskeletal gene expression in vascular smooth muscle via Rho/protein kinase C and actin polymerization.
Hien TT, Turczynska KM, Dahan D, Ekman M, Grossi M, Sjögren J, Nilsson J, Braun T, Boettger T, Garcia Vaz E, Stenkula K, Swärd K, Gomez MF, Albinsson S.
J Biol Chem. 2016 Feb 12;291(7):3552-68. doi: 10.1074/jbc.M115.654384.  PMID: 26683376

FOXO1 couples metabolic activity and growth state in the vascular endothelium.
Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich MF, Lim R, Zimmermann B, Aspalter IM, Franco CA, Boettger T, Braun T, Fruttiger M, Rajewsky K, Keller C, Brüning JC, Gerhardt H, Carmeliet P, Potente M.
Nature. 2016 Jan 14;529(7585):216-20. doi: 10.1038/nature16498.  PMID: 26735015

Cardiac-Specific Activation of IKK2 Leads to Defects in Heart Development and Embryonic Lethality.
Kraut B, Maier HJ, Kókai E, Fiedler K, Boettger T, Illing A, Kostin S, Walther P, Braun T, Wirth T.
PLoS One. 2015 Nov 5;10(11):e0141591. doi: 10.1371/journal.pone.0141591.  PMID: 26539991

Wystub K, Boettger T: miRNAs in Cardiovascular Development. in: Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Edited by Jagadeesh G, Balakumar P, Maung-U K: ADIS; 2015: 1331-1342. doi: 10.1007/978-3-319-15961-4.

Deficient acid handling with distal RTA in the NBCe2 knockout mouse.
Wen D, Yuan Y, Cornelius RJ, Li H, Warner PC, Wang B, Wang-France J, Boettger T, Sansom SC.
Am J Physiol Renal Physiol. 2015 Sep 15 309(6): F523-530. doi: 10.1152/ajprenal.00163.2015.  PMID: 26109087.

Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice.
Bhattachariya A, Dahan D, Ekman M, Boettger T, Braun T, Sward K, Hellstrand P, Albinsson S.
Acta Physiol (Oxf). 2015 Nov 215(3): 133-143. doi: 10.1111/apha.12536.  PMID: 26052659.

Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency.
Wen D, Yuan Y, Warner PC, Wang B, Cornelius RJ, Wang-France J, Li H, Boettger T, Sansom SC.
Hypertension. 2015 Jul 66(1): 68-74. doi: 10.1161/HYPERTENSIONAHA.115.05394.  PMID: 25941340.

Slc5a8, a Na + -coupled high-affinity transporter for short-chain fatty acids, is a conditional tumor suppressor in colon that protects against colitis and colon cancer under low-fiber dietary conditions.
Gurav A, Sivaprakasam S, Bhutia YD, Boettger T, Singh N, Ganapathy V.
Biochem J. 2015 Jul 15 469(2): 267-278. doi: 10.1042/BJ20150242.  PMID: 25984582.

Myocardial healing requires Reg3ß-dependent accumulation of macrophages in the ischemic heart.
Lörchner H, Pöling J, Gajawada P, Hou Y, Polyakova V, Kostin S, Adrian-Segarra JM, Boettger T, Wietelmann A, Warnecke H, Richter M, Kubin T, Braun T.
Nat Med. 2015 Apr 21(4): 353-362. doi: 10.1038/nm.3816.  PMID: 25751817

The miR-206/133b cluster is dispensable for development, survival and regeneration of skeletal muscle.
Boettger T*, Wüst S, Nolte H, Braun T*.
Skelet Muscle. 2014 4(1): 23. doi: 10.1186/s13395-014-0023-5
PMID: 25530839

MiRNA-1/133a Clusters Regulate Adrenergic Control of Cardiac Repolarization.
Besser J, Malan D, Wystub K, Bachmann A, Wietelmann A, Sasse P, Fleischmann BK, Braun T*, Boettger T*.
PLoS One. 2014 Nov 21;9(11):e113449. doi: 10.1371/journal.pone.0113449
PMID: 25415383

Induction of angiotensin converting enzyme after miR-143/145 deletion is critical for impaired smooth muscle contractility.
Dahan D, Ekman M, Larsson-Callerfelt AK, Turczynska K, Boettger T, Braun T, Swärd K, Albinsson S.
Am J Physiol Cell Physiol. 2014 Dec 15 307(12): C1093-1101. doi: 10.1152/ajpcell.00250.2014. PMID: 25273883

tBRD-1 Selectively Controls Gene Activity in the Drosophila Testis and Interacts with Two New Members of the Bromodomain and Extra-Terminal (BET) Family.
Theofel I, Bartkuhn M, Hundertmark T, Boettger T, Gärtner SM, Leser K, Awe S, Schipper M, Renkawitz-Pohl R, Rathke C.
PLoS ONE. 2014 9(9): e108267. doi: 10.1371/journal.pone.0108267.  PMID: 25251222

Myostatin regulates energy homeostasis in the heart and prevents heart failure.
Biesemann N, Mendler L, Wietelmann A, Hermann S, Schäfers M, Krüger M, Boettger T, Borchardt T, Braun T.
Circ Res. 2014 Jul 7 115(2): 296-310. doi: 10.1161/CIRCRESAHA.115.304185.  PMID: 24807786

Hmga2 is required for canonical WNT signaling during lung development.
Singh I, Mehta A, Contreras A, Boettger T, Carraro G, Wheeler M, Cabrera-Fuentes HA, Bellusci S, Seeger W, Braun T, Barreto G.
BMC Biol. 2014 12:21. doi: 10.1186/1741-7007-12-21. PMID: 24661562.

Therapeutic targeting of the oncostatin M receptor-ß prevents inflammatory heart failure.
Pöling J, Gajawada P, Richter M, Lörchner H, Polyakova V, Kostin S, Shin J, Boettger T, Walther T, Rees W, Wietelmann A, Warnecke H, Kubin T, Braun T.
Basic Res Cardiol. 2014 Jan 109(1): 396. doi: 10.1007/s00395-013-0396-3.  PMID: 24292852

Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species.
Pohjoismäki JL, Williams SL, Boettger T, Goffart S, Kim J, Suomalainen A, Moraes CT, Braun T.
Proc Natl Acad Sci U S A. 2013 Nov 26 110(48): 19408-19413. doi: 10.1073/pnas.1303046110. PMID: 24218554.

Quantitative proteome analysis of alveolar type II cells revealed a connection of integrin receptor subunits beta 2/6 and WNT signaling.
Mukhametshina RT, Ruhs A, Singh I, Hasan D, Contreras A, Mehta A, Nikam VS, Ahlbrecht K, Carraro G, Cabrera-Fuentes HA, Jiang D, Voswinckel R, Seeger W, Bellusci S, Scharffetter-Kochanek K, Bagaeva TV, Preissner KT, Boettger T, Braun T, Krüger M, Barreto G.
J Proteome Res. 2012 Oct 31 12(12):5598-608. doi: 10.1021/pr400573k.  PMID: 24175614

miR-1/133a clusters cooperatively specify the cardiomyogenic lineage by adjustment of myocardin levels during embryonic heart development.
Wystub K, Besser J, Bachmann A, Boettger T*, Braun T*.
PLoS Genet. 2013 Sep 9(9): e1003793. doi: 10.1371/journal.pgen.1003793.
  PMID: 24068960.

Molecular Mechanism of SLC5A8-Inactivation in Breast Cancer.
Elangovan S, Pathania R, Ramachandran S, Ananth S, Padia RN, Srinivas SR, Babu E, Hawthorn L, Schoenlein PV, Boettger T, Smith SB, Prasad PD, Ganapathy V, Thangaraju M.
Mol Cell Biol. 2013 Oct 33(19): 3920-3935. doi: 10.1128/MCB.01702-12.  PMID: 23918800.

AMP-Activated Protein Kinase Regulates Endothelial Cell Angiotensin-Converting Enzyme Expression via p53 and the Post-Transcriptional Regulation of microRNA-143/145.
Kohlstedt K, Trouvain C, Boettger T, Shi L, Fisslthaler B, Fleming I.
Circ Res. 2013 Apr 12 112(8): 1150-1158. doi: 10.1161/CIRCRESAHA.113.301282.  PMID: 23476055

Induction of the cystine/glutamate exchanger slc7a11 in retinal pigment epithelial cells by the anti-psoriatic drug monomethylfumarate.
Ananth S, Babu E, Veeranan-Karmegam R, Bozard Baldowski BR, Boettger T, Martin PM.
Invest Ophthalmol Vis Sci. 2013 Mar 54(3): 1592-1602. doi: 10.1167/iovs.12-11289.  PMID: 23404113

Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences.
Günther K, Rust M, Leers J, Boettger T, Scharfe M, Jarek M, Bartkuhn M, Renkawitz R.
Nucleic Acids Res. 2013 Mar 1 41(5): 3010-3021. doi: 10.1093/nar/gkt035. PMID: 2336146

A G13-Mediated Signaling Pathway is Required for Pressure Overload-Induced Cardiac Remodeling and Heart Failure.
Takefuji M, Wirth A, Lukasova M, Takefuji S, Boettger T, Braun T, Althoff T, Offermanns S, Wettschureck N.
Circulation. 2012 Oct 16 126(16): 1972-1982. doi: 10.1161/CIRCULATIONAHA.112.109256. PMID: 22972902

Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart.
Yang J, Bücker S, Jungblut B, Böttger T, Cinnamon Y, Tchorz J, Müller M, Bettler B, Harvey R, Sun QY, Schneider A, Braun T.
Cardiovasc Res. 2012 Nov 1 96(2): 276-285. doi: 10.1093/cvr/cvs250.  PMID: 22865640

Cardiomyocyte-specific IkappaB kinase (IKK)/NF-kappaB activation induces reversible inflammatory cardiomyopathy and heart failure.
Maier HJ, Schips TG, Wietelmann A, Krüger M, Brunner C, Sauter M, Klingel K, Böttger T, Braun T, Wirth T.
Proc Natl Acad Sci U S A. 2012 Jul 17 109(29): 11794-11799. doi: 10.1073/pnas.1116584109. PMID: 22753500

Oxidative stress during mitochondrial biogenesis compromises mtDNA integrity in growing hearts and induces a global DNA repair response.
Pohjoismäki JL, Boettger T, Liu Z, Goffart S, Szibor M, Braun T.
Nucleic Acids Res. 2012 Aug 1 40(14): 6595-6607. doi: 10.1093/nar/gks301.  PMID: 22508755

A New Level of Complexity: The Role of MicroRNAs in Cardiovascular Development.
Boettger T*, Braun T*.
Circ Res. 2012 Mar 30 110(7): 1000-1013. doi: 10.1161/CIRCRESAHA.111.247742.
  PMID: 22461364

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs.
Hergenreider E, Heydt S, Tréguer K, Boettger T, Horrevoets AJ, Zeiher AM, Scheffer MP, Frangakis AS, Yin X, Mayr M, Braun T, Urbich C, Boon RA, Dimmeler S.
Nat Cell Biol. 2012 14(3): 249-256. doi: 10.1038/ncb2441.  PMID: 22327366

The Janus face of OSM mediated cardiomyocyte dedifferentiation during cardiac repair and disease.
Pöling J, Gajawada P, Lörchner H, Polyakowa V, Szibor M, Böttger T, Warnecke H, Kubin T, Braun T.
Cell Cycle. 2012 Feb 1 11(3): 439-445. doi: 10.4161/cc.11.3.19024.  PMID: 22262173

On marathons and sprints: an integrated quantitative proteomics and transcriptomics analysis of differences between slow and fast muscle fibers.
Drexler HC, Ruhs A, Konzer A, Mendler L, Bruckskotten M, Looso M, Gunther S, Boettger T, Kruger M and Braun T.
Mol Cell Proteomics. 2012 Jun 11(6): M111 010801. doi: 10.1074/mcp.M111.010801.  PMID: 22210690

Targeted mutation of SLC4A5 induces arterial hypertension and renal metabolic acidosis.
Gröger N, Vitzthum H, Fröhlich H, Krüger M, Ehmke H, Braun T*, Boettger T*.
Hum Mol Genet. 2012 Mar 1 21(5): 1025-1036. doi: 10.1093/hmg/ddr533
PMID: 22082831

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism.
Jordan SD, Krüger M, Willmes DM, Redemann N, Wunderlich FT, Brönneke HS, Merkwirth C, Kashkar H, Olkkonen VM, Böttger T, Braun T, Seibler J, Brüning JC.
Nat Cell Biol. 2011 Apr 13(4): 434-446. doi: 10.1038/ncb2211.  PMID: 21441927

Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells.
Babu E, Ananth S, Veeranan-Karmegam R, Coothankandaswamy V, Smith SB, Boettger T, Ganapathy V, Martin PM.
Invest Ophthalmol Vis Sci. 2011 Jul 52(8): 5749-5757. doi: 10.1167/iovs.10-6825.  PMID: 21508099

Identification of right heart-enriched genes in a murine model of chronic outflow tract obstruction.
Kreymborg KG, Uchida S, Gellert P, Schneider A, Boettger T, Voswinckel R, Wietelmann A, Szibor M, Weissmann N, Ghofrani AH, Schermuly R, Schranz D, Seeger W, Braun T.
J Mol Cell Cardiol. 2010 Oct 49(4): 598-605. doi: 10.1016/j.yjmcc.2010.07.014.  PMID: 20673770

Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases.
Singh N, Thangaraju M, Prasad PD, Martin PM, Lambert NA, Boettger T, Offermanns S, Ganapathy V.
J Biol Chem. 2010 Sep 3 285(36): 27601-27608. doi: 10.1074/jbc.M110.102947.  PMID: 20601425

Cardiac deletion of smyd2 is dispensable for mouse heart development.
Diehl F, Brown MA, van Amerongen MJ, Novoyatleva T, Wietelmann A, Harriss J, Ferrazz, F, Bottger T, Harvey RP, Tucker PW and Engel FB.
PLoS One. 2010 5(3):e9748. doi: 10.1371/journal.pone.0009748.  PMID: 20305823

Slc4a11 prevents osmotic imbalance leading to corneal endothelial dystrophy, deafness, and polyuria.
Groeger N, Froehlich H, Maier H, Olbrich A, Kostin S, Braun T* and Boettger T*.
J Biol Chem. 2010 May 7 285(19):14467-74. doi: 10.1074/jbc.M109.094680
PMID: 20185830

Defective peripheral nerve development is linked to abnormal architecture and metabolic activity of adipose tissue in Nscl-2 mutant mice.
Ruschke K, Ebelt H, Kloting N, Boettger T, Raum K, Bluher M and Braun T.
PLoS ONE. 2009 4(5):e5516. doi: 10.1371/journal.pone.0005516.  PMID: 19436734

Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster.
Boettger T*, Beetz N, Kostin S, Schneider J, Kruger M, Hein L and Braun, T*.
J Clin Invest. 2009 Sep 119(9):2634-47. doi: 10.1172/JCI38864.
  PMID: 19690389

Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice.
Vakhrusheva O, Smolka C, Gajawada P, Kostin S, Boettger T, Kubin T, Braun T and Bober E.
Circ Res. 2008 Mar 28 102(6):703-10. doi: 10.1161/CIRCRESAHA.107.164558  PMID: 18239138

Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice.
Frank H, Groger N, Diener M, Becker C, Braun T* and Boettger T*.
J Biol Chem. 2008 Sep 5 283(36):24729-37. doi: 10.1074/jbc.M802681200
PMID: 18562324

Directed expression of dominant-negative p73 enables proliferation of cardiomyocytes in mice.
Ebelt H, Zhang Y, Kohler K, Xu J, Gajawada P, Boettger T, Hollemann T, Muller-Werdan U, Werdan K. and Braun T.
J Mol Cell Cardiol. 2008 Sep 45(3):411-9. doi: 10.1016/j.yjmcc.2008.06.006.  PMID: 18634800

Neurogenic mechanisms contribute to hypertension in mice with disruption of the K-Cl cotransporter KCC3.
Rust MB, Faulhaber J, Budack MK, Pfeffer C, Maritzen T, Didie M, Beck FX, Boettger T, Schubert R, Ehmke H, Jentsch TJ and Hubner CA.
Circ Res. 2006 Mar 39 8(4):549-56. doi: 10.1161/01.RES.0000204449.83861.22.
  PMID: 16424367

Comparative application of antibody and gene array for expression profiling in human squamous cell lung carcinoma.
Bartling B, Hofmann HS, Boettger T, Hansen G, Burdach S, Silber RE and Simm A (2005)
Lung Cancer. 2005 Aug 49(2):145-54. doi: 10.1016/j.lungcan.2005.02.006.  PMID: 16022908

Epithelial Ion Transport in Inner Ear and Kidney.
Boettger T.
Nova Acta Leopoldina N. F. 2004 89(336):153-8. ISBN: 3-8047-2169-9

Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold.
Boettger T, Rust MB, Maier H, Seidenbecher T, Schweizer M, Keating DJ, Faulhaber J, Ehmke H, Pfeffer C, Scheel O, Lemcke B, Horst J, Leuwer R, Pape HC, Volkl H, Hubner CA and Jentsch TJ.
Embo J. 2003 Oct 15 22(20):5422-34. doi: 10.1093/emboj/cdg519.
  PMID: 14532115

Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4.
Boettger T, Hubner CA, Maier H, Rust MB, Beck FX and Jentsch TJ.
Nature. 2002 Apr 25 416(6883):874-8. doi: 10.1038/416874a
PMID: 11976689

Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion.
Estevez R, Boettger T, Stein V, Birkenhager R, Otto E, Hildebrandt F and Jentsch TJ.
Nature. 2001 Nov 29 414(6863):558-61. doi 10.1038/35107099.
  PMID: 11734858

The avian organizer.
Boettger T, Knoetgen H, Wittler L and Kessel M.
Int J Dev Biol. 2001 45(1):281-7.
  PMID: 11291858

Transient cardiac expression of the tinman-family homeobox gene, XNkx2-10.
Newman CS, Reecy J, Grow MW, Ni K, Boettger T, Kessel M, Schwartz RJ and Krieg PA.
Mech Dev. 2000 Mar 1 91(1-2): 369-373. doi: 10.1016/s0925-4773(99)00291-9.  PMID: 10704867

FGF8 functions in the specification of the right body side of the chick.
Boettger T, Wittler L and Kessel M.
Curr Biol. 1999 Mar 11 9(5):277-80. doi: 10.1016/s0960-9822(99)80119-5.
  PMID: 0074453

The chicken NKX2.8 homeobox gene: A novel member of the NK-2 gene family.
Boettger T, Stein S and Kessel M.
Dev. Genes Evol. 1997 May 207(1): 65-70. doi: 10.1007/s004270050092.
  PMID: 20607481

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