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Function of non-coding RNAs in the cardiovascular system
The progress in annotation of the mammalian genome has identified non-coding RNAs (ncRNAs) to be an important class of molecules encoded in the genome. The research of our group focuses on two subclasses of ncRNAs, the microRNAs (miRNAs) and the long non-coding RNAs (lncRNAs). We are interested to understand the function of these molecules in the cardiovascular system and skeletal muscle and to get insight into general principles of ncRNA function.
Until now, we identified important physiological functions of miRNAs miR-143/145, miR-22, miR-206/133b and miR-1/133a (Boettger et al., 2009, Boettger & Braun 2012, Wystub et al., 2013, Schweisgut et al., 2017, Wüst et al., 2018, Valussi et al., 2021 and Klockner et al., 2022). In addition we have identified physiological functions and molecular mechanisms of long non-coding RNAs (Schweisgut et al., 2017, Schutt et al., 2020) in the cardiovascular system and skeletal muscle. Some of our findings regarding the functions of ncRNAs are summarized below.
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