AG Yuan

Max-Planck-Institut für Herz- und Lungenforschung - W. G. Kerckhoff-Institut

Diese Informationen sind derzeit nur in englischer Sprache verfügbar.

Scientific focus

Mammals have more than 300 different cell types, which share the same genomic sequence but can be distinguished by their epigenetic signatures. Elucidating the molecular mechanisms controlling different epigenetic signature therefore would help to understand cellular differentiation, cell fate determination in normal development as well as in tissue regeneration. Deregulation of cell identity control often leads to human diseases in cardiopulmonary system and skeletal muscle. In my group we are focusing on understanding the epigenetic mechanisms underlying cell identity control in both physiological and pathophysiological conditions by applying multiply methods in biochemistry, molecular biology, cell biology and mouse genetics, and cutting edge technologies including next generation deep-sequencing, high throughput RNAi screening, quantitative proteomics and advanced microscopy.

Currently there are three major projects pursuing:

Epigenetic modifiers regulating adult muscle stem cell homeostasis and skeletal muscle regeneration in physiological and pathophysiological conditions.

Linking epigenetic regulation to metabolism in cardiopulmonary progenitor cells during development and in cardiomyocytes during adult heart regeneration.

Identification and characterization of novel epigenetic modifiers and modifications involved in regulating one type of lung stem cell called BASC cell during lung regeneration.

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Applicants for Master and PhD are welcome.

Group members:

Angelina Georgieva (post-doc)

Fan Wu (post-doc)

Xiang Li (post-doc)

Dong Ding (post-doc)

Hang Liu (PhD student)

Xinyue Guo (PhD student)

Andreea Bostean Olariu (PhD student)

Hannine Ahmad (PhD student)

Jiawen Chen (PhD student)

Barbara Zimmermann (Lab Manager/ Technical assistant)

Julia Klein (Technical assistant)

Ripandeep Kaur (Technical assistant)

Alumni:

Verawan Boonsanay (PhD, 2014)

Ting Zhang (post-doc)

Johanna Aoyama (Bachelor, 2015)

Hui Qi (post-doc)

Guangshuai Jia (post-doc)

Charbel Raad (Erasmus master student)

Hang Liu (PhD student)

Publications:

2025

Georgieva, A. M.; Sreenivasan, K.; Ding, D.; Villeneuve, C.; Wickstrom, S. A.; Gunther, S.; Kuenne, C.; Gartner, U.; Guo, X.; Zhou, Y. et al.; Yuan, X.; Braun, T.: Regulation of NSL by TAF4A is critical for genome stability and quiescence of muscle stem cells. NATURE COMMUNICATIONS 16 (1), 8726 (2025)

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2024

Yuan, X.; Braun, T.: Toward drug-induced heart regeneration. NATURE CARDIOVASCULAR RESEARCH (2024)

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Wu, F.; Li, X.; Looso, M.; Liu, H.; Ding, D.; Guenther, S.; Kuenne, C.; Liu, S.; Weissmann, N.; Boettger, T. et al.; Atzberger, A.; Kolahian, S.; Renz, H.; Offermanns, S.; Gaertner, U.; Potente, M.; Zhou, Y.; Yuan, X.; Braun, T.: Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine. NATURE GENETICS 55 (1), S. 100 - + (2024)

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2023

Li, X.; Wu, F.; Guenther, S.; Looso, M.; Kuenne, C.; Zhang, T.; Wiesnet, M.; Klatt, S.; Zukunft, S.; Fleming, I. et al.; Poschet, G.; Wietelmann, A.; Atzberger, A.; Potente, M.; Yuan, X.; Braun, T.: Inhibition of fatty acid oxidation enables heart regeneration in adult mice. NATURE (2023)

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Yuan, X.; Braun, T.: Amending the injured heart by in vivo reprogramming. CURRENT OPINION IN GENETICS & DEVELOPMENT 82, 102098 (2023)

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Wu, F.; Li, X.; Looso, M.; Liu, H.; Ding, D.; Guenther, S.; Kuenne, C.; Liu, S.; Weissmann, N.; Boettger, T. et al.; Atzberger, A.; Kolahian, S.; Renz, H.; Offermanns, S.; Gaertner, U.; Potente, M.; Zhou, Y.; Yuan, X.; Braun, T.: Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine. NATURE GENETICS (2023; 55(1)), S. 100 - 111 (2023)

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2022

Zhang, T.; Kuenne, C.; Ding, D.; Guenther, S.; Guo, X.; Zhou, Y.; Yuan, X.; Braun, T.: Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells. NATURE COMMUNICATIONS 13 (1), 6907 (2022)

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Garcia-Gonzalez, C.; Dieterich, C.; Maroli, G.; Wiesnet, M.; Wietelmann, A.; Li, X.; Yuan, X.; Graumann, J.; Stellos, K.; Kubin, T. et al.; Schneider, A.; Braun, T.: ADAR1 Prevents Autoinflammatory Processes in the Heart Mediated by IRF7. CIRCULATION RESEARCH 131 (7), S. 580 - 597 (2022)

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Georgieva, A. M.; Guo, X.; Bartkuhn, M.; Guenther, S.; Kuenne, C.; Smolka, C.; Atzberger, A.; Gaertner, U.; Mamchaoui, K.; Bober, E. et al.; Zhou, Y.; Yuan, X.; Braun, T.: Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression. NATURE COMMUNICATIONS 13 (1), 4184 (2022)

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2021

Qi, H.; Liu, H.; Pullamsetti, S. S.; Gunther, S.; Kuenne, C.; Atzberger, A.; Sommer, N.; Hadzic, S.; Gunther, A.; Weissmann, N. et al.; Zhou, Y.; Yuan, X.; Braun, T.: Epigenetic Regulation by Suv4-20h1 in Cardiopulmonary Progenitor Cells Is Required to Prevent Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease. CIRCULATION 144 (13), S. 1042 - 1058 (2021)

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2019

Gao, R.; Liang, X.; Cheedipudi, S.; Cordero, J.; Jiang, X.; Zhang, Q.; Caputo, L.; Guenther, S.; Kuenne, C.; Ren, Y. et al.; Bhattacharya, S.; Yuan, X.; Barreto, G.; Chen, Y.; Braun, T.; Evans, S. M.; Sun, Y.; Dobreva, G.: Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate. CELL RESEARCH 29 (6), S. 486 - 501 (2019)

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2018

Ianni, A.; Yuan, X.; Bober, E.; Braun, T.: Sirtuins in the Cardiovascular System: Potential Targets in Pediatric Cardiology. PEDIATRIC CARDIOLOGY 39 (5), S. 983 - 992 (2018)

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Jia, G.; Preussner, J.; Chen, X.; Guenther, S.; Yuan, X.; Yekelchyk, M.; Kuenne, C.; Looso, M.; Zhou, Y.; Teichmann, S. et al.; Braun, T.: Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement. NATURE COMMUNICATIONS 9, 4877 (2018)

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2017

Yuan, X.; Braun, T.: Multimodal Regulation of Cardiac Myocyte Proliferation. CIRCULATION RESEARCH 121 (3), S. 293 - 309 (2017)

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Yuan, X.; Qi, H.; Li, X.; Wu, F.; Fang, J.; Bober, E.; Dobreva, G.; Zhou, Y.; Braun, T.: Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice. JOURNAL OF CLINICAL INVESTIGATION 127 (6), S. 2235 - 2248 (2017)

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2016

Boonsanay, V.; Zhang, T.; Georgieva, A.; Kostin, S.; Qi, H.; Yuan, X.; Zhou, Y.; Braun, T.: Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation. CELL STEM CELL 18 (2), S. 229 - 242 (2016)

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