Publications

Yuan X*., Qi, H., Fang, J., Bober, E., Dobreva, G., Zhou, Y., Braun, T^*. Disruption of spatiotemporal hypoxic signaling causes congenital heart disease via epigenetic changes Journal of Clinical Investigation in press, 2017 *: co-responding author

Boonsanay V., Zhang T., Georgieva A., Kostin S., Qi H., Yuan X., Zhou Y*. and Braun T*. (2016) Regulation of skeletal muscle stem cell quiescence by Suv4-20h1 dependent facultative heterochromatin formation. Cell Stem Cell, 18: 229-242 

Zhang, T., Braun, T. and Zhou, Y.  Prmt5 differentiates developmental vs regenerative myogenesis. (2015) Oncotarget, 6:35153-35154

Kuenne, C.*,Guenther, S.*, Looso, M.*, Zhang, T. Krueger, M.,  Zhou, Y., Braun, T. and Kim, J. (2015) “RNA-Seq analysis of isolated satellite cells in Prmt5 deficient mice”, Genomics Data. 

Zhang, T., Günther, S., Looso, M., Künne, C., Krüger, M., Kim, J.*, Zhou, Y.* and Braun, T.* (2015) Prmt5 is a crucial regulator of muscle stem cell expansion in adult mice. Nat. Communications 10.1038/ncomms8140. (Corresponding author)

Yuan X., Braun T. (2013) An unexpected switch: regulation of cardiomyocyte proliferation by the homeobox gene meis1. Circ Res. 113, 245-248.

Luo M, Ling T, Xie W, Sun H, Zhou Y, Zhu Q, Shen M, Zong L, Lyu G, Zhao Y, Ye T, Gu J, Tao W, Lu Z and Grummt I. (2013) NuRD Blocks reprogramming of mouse somatic cells into pluripotent stem cells. Stem Cells. 31, 1278-1286.

Boonsanay V., Kim J., Braun T.* and Zhou Y.* (2013) The emerging role of epigenetic modifiers linking cellular metabolism to gene activity in cardiac progenitor cells. Trends in Cardiovascular Medicine. 22(3), 77-81. (*Corresponding author).

Xie W*, Ling T*, Zhou Y*, Feng W, Zhu Q, Stunnenberg H, Grummt I and Tao W. (2012). The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions. PNAS 109, 8161-8166. (* Equal contribution).

Zhou Y*, Kim J, Yuan X, Braun T*. Epigenetic modifications of stem cells: a paradigm for the control of cardiac progenitor cells. Circ Res 109: 1067-1081, 2011 *corresponding author

Rieker C, Engblom D, Kreiner G, Domanskyi A, Schober A, Stotz S, Neumann M, Yuan X. Grummt I, Schütz G, Parlato R. (2011). Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling. J Neurosci. 31, 453-460.

Zhou, Y.*, Schmitz, K.*, Mayer, C., Yuan, X., Akhtar, A., and Grummt, I.: Reversible acetylation of the chromatin remodeling complex NoRC is required for non-coding RNA-dependent silencing. Nat Cell Biol., 2009; 11:1010-1016. (* Equal contribution).

Shen, C., Zhou, Y., Zhan, J., Reske, S.N. and Buck, A.K.: Chromosome instability and tumor lethality suppression in carcinogenesis. J Cell Biochem., 2008; 105:1327-1341

Liu, W., Zhou, Y., Reske, S.N and Shen, C.: PTEN mutation: many birds with one stone in tumorigenesis. Anticancer Res., 2008; 28:3613-3619

Yuan, X., Feng, W., Imhof, A., Grummt, I. and Zhou, Y.: Activation of RNA polymerase I transcription by Cockayne’s Syndrome group B (CSB) and histone methyltransferase G9a. Mol Cell. 2007; 27:585-595

Zhou, Y. and Grummt, I. (2005) The PHD finger/bromodomain of NoRC interacts with acetylated histone H4 K16 and is sufficient for rDNA silencing. Current Biol, 2005;15:1434-1438.

Yuan, X., Zhou, Y., Casanova, E., Chai, M., Kiss, E., Grone, H., Schultz., G and Grummt I. (2005) Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest and p53-mediated apoptosis. Mol Cell,19;77-87. 

Mayer C, Zhao J, Yuan X, Grummt I. (2004) mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes & Dev. 18; 423-434.

Zhao J, Yuan X, Frödin M, Grummt I. (2003). ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. Mol Cell. 11, 05-13.

Yuan X, Zhao J. Zentgraf H., Hoffmann-Rohrer U. and Grummt I. (2002). Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. EMBO Rep., 3, 1082-1087.

Zhou, Y., Santoro, R. and Grummt, I. (2002) The nucleolar chromatin remodeling complex targets HDAC1 to ribosomal gene and represses pol I transcription, Embo J., 21:4632-4640