Publications

Li X, Wu F, Günther S, Looso M, Kuenne C, Zhang T, Klatt S, Zukunft S, Fleming I, Poschet G, Wietelmann A, Atzberger A, Potente M, Yuan X* and Braun T*.  (2023) Inhibition of fatty acid oxidation stimulates KDM5-mediated H3K4me3 demethylation and enables heart regeneration in adult mice. Nature, in press. doi: 10.1038/s41586-023-06585-5.*Co-corresponding author

Yuan X* & Thomas Braun*. (2023) Amending the injured heart by in vivo reprogramming. (2023)  Curr Opin Genet Dev. 82:102098. doi: 10.1016/j.gde.2023.102098. *Co-corresponding author

Wu F, Li X, Looso M, Liu H, Ding D, Günther S, Kuenne C, Liu S, Weissmann N, Böttger T, Atzberger A, Kolahian S, Renz H, Offermanns S, Gärtner U, Potente M, Zhou Y, Yuan X* and Thomas Braun*. (2022) Spurious transcription causing innate immune responses is prevented by 5hmC. Nat Genet 55:100-111. doi: 10.1038/s41588-022-01252-3. *Co-corresponding author

Zhang T, Künne C, Ding D, Günther S, Guo X, Zhou Y, Yuan X*, Braun T*. (2022) Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells. Nat Commun 13:6907. doi: 10.1038/s41467-022-34577-y. *Co-corresponding author

Georgieva A, Bober E, Smolka C, Zhou Y, Yuan X*, Braun T* (2022). Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression. Nat Commun 13:4184. doi: 10.1038/s41467-022-31798-z. *Co-corresponding author

Garcia-Gonzalez C, Dieterich C, Maroli G, Wiesnet M, Wietelmann A, Li X, Yuan X, Graumann J, Stellos K, Kubin T, Schneider A, Braun T. (2022)  ADAR1 prevents autoinflammatory processes in the heart mediated by IRF7. Circ Res 101161

Qi H, Liu H, Pullamsetti S, Günther S, Kuenne C, Atzberger A, Sommer N, Hadzic S, Günther A, Weissmann N, Zhou Y, Yuan X*, Braun T* (2021). Epigenetic regulation by Suv4-20h1 in cardiopulmonary progenitor cells is required to prevent pulmonary hypertension and COPD. Circulation 144:1042-1058. doi:10.1161/CIRCULATIONAHA.120.051680. *Co-corresponding author

Gao R, Liang X, Cheedipudi S, Cordero J, Jiang X,  Zhang Q, Caputo L, Günther S, Kuenne C, Ren Bhattacharya S, Yuan X., Barreto G, Chen Y, Braun T, Evans S, Sun Y and Dobreva G. (2019). Pioneering function of Isl1 in epigenetic control of cardiomyocyte cell fate. Cell research 29: 486-501

Jia, G., Preussner, J., Guenther, S., Yuan, X., Yekelchyk, M., Kuenne, C., Looso, M, Zhou, Y. and Braun, T. (2018). Single cell RNA-seq and ATAC-seq indicate critical roles of Isl1 and Nkx2-5 for cardiac progenitor cell transition states and lineage settlement. Nat Commun 9, 4877. doi: 10.1038/s41467-018-07307-6

Ianni A, Yuan X, Bober E, Braun T. Sirtuins in the Cardiovascular System: Potential Targets in Pediatric Cardiology. Pediatr Cardiol. (2018) Jun;39 (5):983-992

Yuan X, Braun T. Multimodal regulation of cardiomyocyte proliferation (2017). Circ Res 121:293-309, 2017. doi: 10.1161/CIRCRESAHA.117.308428

Yuan X*., Qi, H., Fang, J., Bober, E., Dobreva, G., Zhou, Y., Braun, T*. (2017). Disruption of spatiotemporal hypoxic signaling causes congenital heart disease via epigenetic changes. J of Clin Invest 127:2235-2248, doi: 10.1172/JCI88725. *: co-responding author

Boonsanay V., Zhang T., Georgieva A., Kostin S., Qi H., Yuan X., Zhou Y*. and Braun T*. (2016) Regulation of skeletal muscle stem cell quiescence by Suv4-20h1 dependent facultative heterochromatin formation. Cell Stem Cell, 18: 229-242

Zhang, T., Braun, T. and Zhou, Y.  (2015) Prmt5 differentiates developmental vs regenerative myogenesis. Oncotarget, 6:35153-35154

Kuenne, C.*,Guenther, S.*, Looso, M.*, Zhang, T. Krueger, M.,  Zhou, Y., Braun, T. and Kim, J. (2015) “RNA-Seq analysis of isolated satellite cells in Prmt5 deficient mice”, Genomics Data. 

Zhang, T., Günther, S., Looso, M., Künne, C., Krüger, M., Kim, J.*, Zhou, Y.* and Braun, T.* (2015) Prmt5 is a crucial regulator of muscle stem cell expansion in adult mice. Nat. Communications 10.1038/ncomms8140. (Corresponding author)

Yuan X., Braun T. (2013) An unexpected switch: regulation of cardiomyocyte proliferation by the homeobox gene meis1. Circ Res. 113, 245-248

Luo M, Ling T, Xie W, Sun H, Zhou Y, Zhu Q, Shen M, Zong L, Lyu G, Zhao Y, Ye T, Gu J, Tao W, Lu Z and Grummt I. (2013) NuRD Blocks reprogramming of mouse somatic cells into pluripotent stem cells. Stem Cells. 31, 1278-1286

Boonsanay V., Kim J., Braun T.* and Zhou Y.* (2013) The emerging role of epigenetic modifiers linking cellular metabolism to gene activity in cardiac progenitor cells. Trends in Cardiovascular Medicine. 22(3), 77-81. *Corresponding author

Xie W*, Ling T*, Zhou Y*, Feng W, Zhu Q, Stunnenberg H, Grummt I and Tao W. (2012). The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions. PNAS 109, 8161-8166. *Equal contribution

Zhou Y*, Kim J, Yuan X, Braun T*. Epigenetic modifications of stem cells: a paradigm for the control of cardiac progenitor cells. Circ Res 109: 1067-1081, 2011 *Corresponding author

Rieker C, Engblom D, Kreiner G, Domanskyi A, Schober A, Stotz S, Neumann M, Yuan X. Grummt I, Schütz G, Parlato R. (2011). Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling. J Neurosci. 31, 453-460

Zhou, Y.*, Schmitz, K.*, Mayer, C., Yuan, X., Akhtar, A., and Grummt, I.: Reversible acetylation of the chromatin remodeling complex NoRC is required for non-coding RNA-dependent silencing. Nat Cell Biol., 2009; 11:1010-1016. * Equal contribution

Shen, C., Zhou, Y., Zhan, J., Reske, S.N. and Buck, A.K.: Chromosome instability and tumor lethality suppression in carcinogenesis. J Cell Biochem., 2008; 105:1327-1341

Liu, W., Zhou, Y., Reske, S.N and Shen, C.: PTEN mutation: many birds with one stone in tumorigenesis. Anticancer Res., 2008; 28:3613-3619

Yuan, X., Feng, W., Imhof, A., Grummt, I. and Zhou, Y.: Activation of RNA polymerase I transcription by Cockayne’s Syndrome group B (CSB) and histone methyltransferase G9a. Mol Cell. 2007; 27:585-595

Zhou, Y. and Grummt, I. (2005) The PHD finger/bromodomain of NoRC interacts with acetylated histone H4 K16 and is sufficient for rDNA silencing. Current Biol, 2005;15:1434-1438

Yuan, X., Zhou, Y., Casanova, E., Chai, M., Kiss, E., Grone, H., Schultz., G and Grummt I. (2005) Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest and p53-mediated apoptosis. Mol Cell,19;77-87

Mayer C, Zhao J, Yuan X, Grummt I. (2004) mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes & Dev. 18; 423-434

Zhao J, Yuan X, Frödin M, Grummt I. (2003). ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. Mol Cell. 11, 05-13

Yuan X, Zhao J. Zentgraf H., Hoffmann-Rohrer U. and Grummt I. (2002). Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. EMBO Rep., 3, 1082-1087

Zhou, Y., Santoro, R. and Grummt, I. (2002) The nucleolar chromatin remodeling complex targets HDAC1 to ribosomal gene and represses pol I transcription, Embo J., 21:4632-4640