In vitro and ex vivo culture systems to model distinct aspects of lung (patho-) physiology

2D air-liquid interface cultures (ALI), complex 3D organoid models or precision-cut lung slices (PCLS) mimic to varying degrees the cellular and structural complexity of the lung. In vitro/ex vivo cultures are used to e.g. model the bronchiolar niche and study the characteristics of airway epithelial cells, to test the capacity of different mesenchymal stem cell subsets in promoting the growth, maintenance and differentiation of epithelial progenitor cells or to screen the properties of potential therapeutic molecules.
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