Studying bronchiolar regeneration at three-dimensional spatial resolution

Regional stem cell niches

Regenerating Club cells emerge as patches at distinct anatomical positions (i.e. at airway bifurcations and bronchioalveolar duct junctions) during the initial recovery phase.

The animated movies were created from 3D reconstructions of endogenous mCherry fluorescence in cleared whole lung preparations isolated from non-injured (ctrl.) and toxin-challenged Scgb1a1-mCherry animals at 7 days post naphthalene (dpn).

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