Semaphorin-plexin signaling 

Project leaders: Dr. Remy Bonnavion
Technical Assistants: Daniel Heil, Dagmar Magalei

Work in this research area has focused on plexins of the B-family. Currently, new cellular mechanisms of plexin signaling as well as cell-type specific in vivo functions of particular semaphorin plexin pairs are analyzed. Recently, a role of plexin-B1 in mediating the prometastatic effects of ErbB-2 (Worzfeld et al, 2012) and of B-family plexins in the regulation of epithelial polarity have been discovered (Xia et al, 2015).


  • Vogler M, Oleksy A, Schulze S, Fedorova M, Kojonazarov B, Nijjar S, Patel S, Jossi S, Sawmynaden K, Henry M, Brown R, Matthews D, Offermanns S, Worzfeld T. (2022) An antagonistic monoclonal anti-Plexin-B1 antibody exerts therapeutic effects in mouse models of postmenopausal osteoporosis and multiple sclerosis. J Biol Chem. 22 July 2022, 102265 [epub ahead of print]
  • Xia J, Swiercz JM, Bañón-Rodríguez I, Sun T, Frederico G, Matkovic I, Franz T, Brakebusch CH, Kumanogoh A, Friedel RH, Martín-Belmonte F, Gröne HJ, Offermanns S, Worzfeld T. (2015) Semaphorin-plexin signaling controls mitotic spindle orientation during epithelial morphogenesis and repair. Dev. Cell  33, 299-313
  • Worzfeld T, Offermanns S. (2014) Semaphorins and plexins as therapeutic targets. Nat. Rev. Drug Discov. 13, 603-21
  • Worzfeld T, Swiercz JM, Sentürk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chan AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S. (2014) Genetic dissection of plexin signaling in vivo. Proc. Natl. Acad. Sci. U. S. A. 111, 2194-9
  • Worzfeld T, Swiercz JM, Looso M, Straub BK, Sivaraj KK, Offermanns S. (2012) ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis. J. Clin. Invest. 122, 3296-2305
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