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Illustration of genetics: plants and DNA structures, a human silhouette, cityscape, sun, and animals.

Renowned scientists, including Didier Stainier from the Max Planck Institute for Heart and Lung Research in Bad Nauheim, argue in the journal Genetics for a paradigm shift in the field of genetics. In their view, classical Mendelian genetics is not sufficient to explain complex gene effects in interaction with the environment and genetic background. more

Laser confocal microscope image of a ‘sleeping’ tumour cell (green) in the vicinity of a blood vessel (red/blue).

Membrane protein PEAR1 prevents the development of metastases
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Full muscle power only with TAF4A: If the transcription factor is active in muscle stem cells, the cell nuclei are intact (top left), while the absence of TAF4A results in unstable cell nuclei (top right). As a result, the regenerative capacity of muscles (bottom row) without TAF4A (right) is severely impaired. In comparison, the muscle cells in the tissue section of control animals with TAF4A appear regular and intact.

Transcription factor TAF4A preserves nuclei in muscle stem cells and initiates muscle regeneration after injury
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Smooth muscle cells under a fluorescence microscope

GPR153 promotes inflammatory reactions in the vessel wall in response to acute damage more

Digital image of the heart in a human chest

RBPMS and RBPMS2 regulate cell division and function during heart development more

3 people in formal dress

A team of researchers at the Max Planck Institute for Heart and Lung Research, led by Prof. Dr. Didier Y.R. Stainier, has been awarded a prestigious ERC Proof of Concept (PoC) grant to advance a groundbreaking RNA-based therapeutic strategy for Duchenne Muscular Dystrophy (DMD). more

Award ceremony, several people on stage

Foundation of the former German President and his wife honours innovative therapeutic approach for Duchenne muscular dystrophy more

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