Pullamsetti Lab

Pullamsetti Lab

Molecular Mechanisms of Pulmonary Vascular Diseases

Prof. Dr. Soni Savai Pullamsetti is a principle investigator at the Max Planck Institute for Heart and Lung Research, Bad Nauheim, and professor at the Department of Internal Medicine, Justus Liebig University Giessen, Germany. Prof. Dr. Pullamsetti received her undergraduate degree from Osmania University, and Master of Science in Biotechnology from Central University, India. After finishing her PhD and postdoctoral work at Justus Liebig University, from 2011, she is appointed as a Principal Investigator in the Department of Lung Development and Remodeling at the Max Planck Institute for Heart and Lung Research in Bad Nauheim.

Prof. Dr. Pullamsetti serves as a co-area leader in the “Excellence Cluster for Cardio Pulmonary System (ECCPS II)”, a program committee member of the American Thoracic Society (ATS), and as a project leader and member of German Lung Center (DZL), and collaborative research center on lung diseases (UGMLC). Prof. Dr. Pullamsetti published in well-renowned scientific journals such as Nature Medicine, Science Translational Medicine, Journal of Clinical Investigation, American Journal of Respiratory and Critical Care Medicine, Circulation, International Journal of Cardiology and Molecular Biology of the Cell (Publications list Pullamsetti). She serves as a reviewer for well-renowned scientific journals. Currently she is serving at the editorial board of Scientific Reports and Pulmonary Vascular Research Institute (PVRI).

 

Scientific Focus
Prof. Dr. Pullamsetti has long standing interest in understanding the molecular mechanisms underlying Pulmonary Hypertension and Pulmonary Fibrosis with the goal of developing novel therapeutic strategies.

Understanding the molecular mechanisms underlying Pulmonary Hypertension

Pulmonary Hypertension is a progressive disease of multifactorial etiology, which has a poor prognosis and results in right heart failure. Based on histopathological appearance and treatment modalities, five subclasses of chronic Pulmonary Hypertension have been defined. However, to date, current therapies provide symptomatic relief and improves prognosis, but falls short of re-establishing structural and functional lung vascular integrity, and thus, handicap-free long-term survival. 

Prof. Dr. Pullamsetti's group contributed to the discovery of tyrosine kinases and phosphodiesterases involvement in the neoplastic nature of the remodeled pulmonary vasculature of Pulmonary Hypertension and parenchymal remodeling underlying Pulmonary Fibrosis. She has studied these signaling pathways in great detail and explored their therapeutic potential for PH treatment successfully and forwarding therapeutic concepts from “Bench to Bedside”. 

 

Recently, Prof. Dr. Pullamsetti's group research has focused to delineate the role of central downstream molecules, with a major focus on transcription factors (FoxO, Beta-catenin, HIF) and epigenetic mechanisms to different forms of Pulmonary Hypertension and to develop novel therapeutic strategies to reverse this devastating disease.

 

Specific projects:

  • Forkhead box O (FoxO) transcription factors role in the pathogenesis of Pulmonary Hypertension and Right Ventricular Remodeling
  • Beta-Catenin role in the pathogenesis of Pulmonary Hypertension and Right Ventricular Remodeling
  • Hippo signaling family: Role and regulation in Pulmonary Hypertension
  • Genome-wide mapping of epigenetic landscape in human Pulmonary Hypertension
  • Role and regulation of class I and IIa HDACs in Pulmonary Hypertension
  • Role of Jumonji domain containing proteins in Pulmonary Hypertension
  • Histological and molecular characterization of distal vascular remodeling in Chronic Thromboembolic Pulmonary Hypertension

Understanding the molecular mechanisms underlying Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis (IPF) belongs to the family of Idiopathic Interstitial Pneumonias (IIPs), representing the most aggressive form of a diffuse parenchymal lung disease and affecting up to 500.000 patients in the western world. With the exception of Pirfenidone and Nintedanib, there are currently no approved therapies for IPF, and IPF is still a disease with significant morbidity and mortality. Unraveling the molecular basis behind the remodeling events in the lung parenchyma, resulting in the loss of gas exchange units and the deposition of scar tissue in lung fibrosis, is desirable. 

 

Specific projects:

  • Forkhead box O (FoxO) transcription factors role in the pathogenesis of Pulmonary Fibrosis
  • Role and regulation of class IIa HDACs in Pulmonary Fibrosis

Group Members

 

Post Docs:

Dr. Prakash Chelladurai
Dr. Anoop Cherian
Dr. Argen Mamazhakypov
Dr. Pouya Sarvari

Doctoral Students:

Edibe Avci
Golnaz Hesami
Dijana Iloska
Leili Jafari
Fatemeh Khassafi
Sreenath Nayakanti

Chanil Valasarajan

Research Assistants:

Ludmila Sperling

Technical Assistants:

Uta Eule
Jana Rostkovius

Natascha Wilker

 

Alumni:

Hamza Al-Tamari
Nina Bender
Swati Dabral
Elisabetta Gamen
Dijana Iloska
Christian Mücke
Jennifer Pott
Mario Schmoranzer
Sabrina Zydek

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