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Entwicklung und Umbau des Herzens (Abt. I)

Diese Informationen sind derzeit nur in englischer Sprache verfügbar.

 

Department Director:

Prof. Dr. med. Dr. rer. nat. habil. Thomas Braun

 

 

Publikationen

2019

2018

2017

2016

 

 

Publications (2008-2015)

 
2015
Nitzki, F.,  Cuvelier, N., Dräger, J., Schneider, A., Braun, T., Hahn, H.:
Hedgehog/Patched-associated rhabdomyosarcoma formation from Delta1-expressing mesodermal cells.
Oncogene. 2015 Sep 21. doi: 10.1038/onc.2015.346.

Ntokou, A., Klein, F., Dontireddy, D., Becker, S., Bellusci, S., Richardson, W. D., Szibor, M., Braun, T., Morty, R., Seeger, W., Voswinckel, R., Ahlbrecht, K.:
Characterization of the platelet-derived growth factor receptor a-positive cell lineage during murine late lung development.
Am. J. Physiol. Lung Cell. Mol. Physiol. Aug 28:ajplung.00272.2014. doi: 10.1152/ajplung.00272.2014.

Caputo, L., Witzel, H. R., Kolovos, P., Cheedipudi, S., Looso, M. Mylona, A., van Ijcken, W. F., Laugwitz, K.-L., Evans, S. M., Braun, T., Soler, E., Grosveld, F., Dobreva, G.:

The Isl1/Ldb1 complex orchestrates heart-specific chromatin organization and transcriptional regulation.

Cell Stem Cell 17, 287-299

 

Zebrowski, D. C., Vergarajauregui, S., Wu, C.-C., Piatkowski, T., Robert Becker, R., Leone, M., Hirth, S., Ricciardi, F., Falk, N., Giessl, A., Just, S., Braun, T., Weidinger, G., Engel, F. B:

Centrosome disassembly promotes a post-mitotic state in mammalian cardiomyocytes.
Elife. Aug 6;4. doi: 10.7554/eLife.05563.

Araki, S., Izumiya, Y., Rokutanda, T., Hanatani, S., Kimura, Y., Senokuchi, T., Yoshizawa, T., Yasuda, O., Jinnin, M., Kadomatsu, T., End, M., Izumi, Y., Ihn, H., Oike, Y., Asada, Y., Braun, T., Bober, E., Yamagata, K., Ogawa, H:
Sirt7 Contributes to Wound Healing Processes by Inhibiting PICK1-mediated TGF-ß Receptor Degradation.
Circulation, pii: CIRCULATIONAHA.114.014821.

 

Buyandelger, B., Mansfield, C., Kostin, S., Choi, O., Roberts, A. M., Ware, J. S., Mazzarotto, F., Pesce, F., Buchan, R., Isaacson, R. L., Vouffo, J., Gunkel, S., Knöll, G., McSweeney, S. J., Wie, H., Perrot, A., Pfeiffer, C., Toliat, M. R., Ilieva, K., Krysztofinska, E., López-Olañeta, M. M., Gómez-Salinero, J. M., Schmidt, A., Ng, K. E., Teucher, N., Chen, J., Teichmann, M., Eilers, M., Haverkamp, W., Regitz-Zagrosek, V., Hasenfuss, G., Braun, T., Pennell, D. J., Gould, I., Barton, P. J., Lara-Pezzi, E., Schafer. S., Hübner, N., Felkin, L. E., O'Regan, D. P., Petretto, E., Brand, T., Milting, H., Nürnberg, P., Schneider, M. D., Prasad, S., Knöll, R:

ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure.
Circ Cardiovasc Genet. 2015 Jul 14. pii: CIRCGENETICS.113.000690.

Bhattachariya, A., Dahan, D., Ekman, M., Boettger, T., Braun, T., Swärd, K., Hellstrand, P., Albinson: 
Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice.
Acta Physiologica doi: 10.1111/apha.12536.

Al-Furoukh, N., Ianni, A., Nolte, H., Hölper, S., Krüger, M., Wanrooij, M., Braun, T:
ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells. Biochem. Biophys.
Acta, Biochim Biophys Acta. doi: 10.1016/j.bbamcr.2015.06.016.

Singh, I., Ozturk, N., Cordero, J., Mehta, A., Hasan, D., Cosentino, C., Sebastian, C., Krüger, M. Looso, M., Carraro, G., Saverio Bellusci, S., Seeger, W., Braun, T., Mostoslavsky, R., Barreto, G.:

High mobility group protein-mediated transcription requires DNA damage marker Gamma-H2AX.
Cell Research. DOI: 10.1038/cr.2015.67

Zhang, T., Krüger, M., Kim, J. Zhou, Y., Braun, T:
Functional analysis of the satellite cell proteome identifies Prmt5 as a crucial regulator of muscle stem cell expansion in adult mice.
Nature Comm. 6, 7140. DOI:10.1038/ncomms8140.

Biesemann, N., Braun T:
Response to letter regarding "myostatin regulates energy homeostasis in the heart and prevents heart failure".
Circ Res. 116:e97-98.

Schild, M., Ruhs, A., Beiter, T., Zuegel, M., Hudemann, J., Schmidt, A., Krumholz, I., Wagner, C., Keller, J., Eder, K., Krüger, K., Krüger, M., Braun, T. Andreas Nieß, A. Steinacker, J.,  Mooren, F. C:
Basal and exercise induced label-free quantitative protein profiling of m. vastus lateralis in trained and untrained individuals.
J. Proteome Res. 122:119-132. doi: 10.1016/j.jprot.2015.03.028.

Mehta, A., Dobersch, S., Dammann, R. H., Bellusci, S., Ilinskaya, O. N., Braun, T., Barreto, G:
Validation of Tuba1a as Appropriate Internal Control for Normalization of Gene Expression Analysis during Mouse Lung Development.
Int J Mol Sci. 2015 Feb 25;16(3):4492-511. doi: 10.3390/ijms16034492.

Lörchner, H., Jochen Pöling, J., Gajawada, P., Hou, Y., Polyakova, V., Kostin, S., Böttger, T., Wietelmann, A., Warnecke, H., Kubin, T., Braun, T:

Myocardial healing requires Reg3ß-dependent accumulation of macrophages in the ischemic heart.

Nature Med.21, 353-362.


Biesemann, N., Luca Mendler, L., Kostin, S., Borchardt, T., Braun, T:
Myostatin induces interstitial fibrosis in the heart via TAK1 and p38.
Cell Tissue Res. PMID: 25725788

Piatkowski T, Braun T:
Long-term organ cultures of newt hearts.
Methods Mol Biol. 1290, 241-251. doi: 10.1007/978-1-4939-2495-0_19.

Looso M, Braun T:
Data mining in newt-omics, the repository for omics data from the newt.
Methods Mol Biol.1290, 337-351. doi: 10.1007/978-1-4939-2495-0_26.

Dobreva, G. Braun, T:
The transcriptional landscape of regenerating newborn mouse hearts.
Circ. Res. 116, 767-769.

Baán, J. A., V. Vargab, Z. V., Leszekc, P., Kusmierczykc, M., Duxa, L., Ferdinandy, P., Braun, T. Mendler, L:

Myostatin and IGF-I signaling in end-stage human heart failure: a qRT-PCR study. Journal of Translational Medicine, J. Transl. Med. 13(1), 1.


Kim, J., Braun, T:
Targeting the cellular origin of organ fibrosis.
Cell Stem Cell 16, 3-4

 


2014

Polyakova, V. Richter; M., Ganceva, N., Lautze, H.-J., Kamata, S., Pöling, J., Beiras-Fernandez, A., Heina, S., Szalay, Z., Braun, T., Walther, T., Kostin, S:

Distinct structural and molecular features of the myocardial extracellular matrix remodeling in compensated and decompensated cardiac hypertrophy due to aortic stenosis.

International J. Cardiology Heart and Vessels 4, 145-160.

 

Hoelper, S., Nolte, H., Bober, E. Braun, T., Krüger, M:

Dissection of metabolic pathways in the Db/Db mouse model by integrative proteome and acetylome analysis.

Mol. BioSyst., 11, 908-922.


Sousounis, K., Bhavsar, R., Looso, M., Krüger, M., Beebe, J., Braun, T., Tsonis, P. A:

Molecular signatures that correlate with induction of lens regeneration in newts: lessons from proteomic analysis.
Hum Genomics 11;8(1):22.

Boettger, T., Wüst, S., Nolte, H., Braun, T:
The miR-206/133b cluster is dispensable for Development, Survival and Regeneration of Skeletal Muscle.
Skeletal Muscle, 4, 23, DOI: 10.1186/s13395-014-0023-5

Nolte, H., Hölper, S., Housley, M. P., Islam, S., Piller, T., Konzer, A., Stainier, D. Y. R., Braun, T., Krüger, M:
Dynamics of Fin Regeneration in Zebrafish Using a Pulsed SILAC Approach.

Proteomics. 2014 Dec 15. doi: 10.1002/pmic.201400316.

 

Ogawa, R., Ma, Y., Yamaguchi, M., Ito, T., Watanabe, Y., Ohtani, T., Satoshi Murakami, S., Uchida, S., De Gaspari, P., Uezumi, A., Nakamura, M., Miyagoe-Suzuki, Y., Kazutake Tsujikawa, K., Hashimoto, N., Braun, T., Tanaka, T., Takeda, S., Yamamoto, H., Fukada, S:

Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration.

Development, pii: 112557. [Epub ahead of print]. PMID: 25480916. 


Besser, J., Malan, D., Wystub, K., Bachmann, A., Wietelmann, A., Sasse, P.,  Fleischmann, B. K., Braun,T.*, Boettger, T.*:
miR-1/133a clusters regulate adrenergic control of cardiac repolarization.
PlosOne 9, e113449. doi: 10.1371/journal.pone.0113449 (* joint senior authorship)

 


Nolte, H., Hölper, S., Selbach, M., Braun, T., Krüger, M.:
Assessment of serum protein dynamics by native SILAC flooding (SILflood).
Anal. Chem. 86(22):11033-7. doi: 10.1021/ac502883p.

Stubenvoll, A., Rice, M., Wietelmann, A., Wheeler, M., Braun, T.:
Attenuation of Wntß/-catenin activity reverses enhanced generation of cardiomyocytes and cardiac defects caused by the loss of emerin.
Human Mol. Genetics, 24, 802-813.

Dahan, D., Ekman, M., Larsson-Callerfelt, A.-K., Turczynska, K., Boettger, T., Braun, T., Swärd, K., Albinsson S.:
Induction of angiotensin converting enzyme after miR-1 143/145 deletion is critical for impaired smooth muscle contractility.
Am. J. Physiol.-Cell Physiol. doi: 10.1152/ajpcell.00250.2014.

Yang, J., Hung, L.-H., Licht, T., Kostin, S., Looso, M., Khrameeva, E., Bindereif, A., Schneider, A., Braun, T.: 
RBM24 is a major regulator of muscle-specific alternative splicing.
Dev. Cell, 31, 87–99.

Katsirntaki, K., Mauritz, C., Olmer, R., Schmeckebier,S., Sgodda, M., Puppe, V., Eggenschwiler R., Duerr, J., Schubert, S. C., Schmiedl, A., Ochs, M., Cantz, T., Salwig, I. Szibor, M., Braun, T. Rathert C., Martens A.,  Mall, M. A., Martin, U.:

Bronchoalveolar sublineage specification of pluripotent stem cells: effect of dexamethasone plus cAMP-elevating agents and keratinocyte growth factor.
Tissue Engineering A, Oct 15.

 

Haldar, M., Karan, G., Watanabe, S., Guenther, S., Braun, T., Capecchi, M. R.:

Contributions of the Myf5-independent lineage to myogenesis.
Dev. Cell 31, 539-541.

Kim, J., Braun, T.:
Skeletal Muscle Stem Cells for Muscle Regeneration.
Methods Mol Biol. 1213, 245-253.
 
Kuenne, C., Preussner, J., Herzog, M., Braun, T. Looso, M.:
MIRPIPE – quantification of microRNAs in niche model organisms.
Bioinformatics pii:btu573

 

Al-Furoukh, N., Kardon, J., Krüger, M., Szibor, M., Baker, T., Braun,T.:

TNOA1, a novel ClpXP substrate, requires nuclear shuttling prior to import into mitochondria.
PlosOne 2014; 9, (7) e103141. doi: 10.1371/journal.pone.0103141

 

Singh, I., Metha, A., Contreras, A., Carraro, G., Wheeler, M., Cabrera-Fuentes, H. A., Bellusci, S., Seeger, W., Braun, T., and Barreto, G.:
Hmga2 is required for canonical WNT signaling during lung development.
BMC Biol. 2014;12, 21. doi:10.1186/1741-7007-12-21

 

Nadine Biesemann, N., Mendler, L., Wietelmann, A., Boettger, T., Borchardt, T., Braun, T.:
Myostatin regulates energy homeostasis in the heart and prevents heart failure.
Circ. Res. 2014;doi: 10.1161/ CIRCRESAHA.115.304185

 

Yoshizawa, T., Karim, F., Senokuchi, T., Sato, Y., Fukuda, T., Go, C., Miyata, K., Tasaki, M., Smolka, C., Sawa, T., Takeya, M., Tomizawa, K., Ando, Y., Araki, E., Oike, Y, Akaike, T., Braun, T., Bober, E., Yamagata, K.:
SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.
Cell Metabolism 2014; 19, 712-721.

 

Hoffmann, J., Ospelt, M., Troidl, C., Voss, S., Liebetrau, C., Kim, W.-K., Rolf, A., Wietelmann, A., Braun, T., Troidl, K., Sadayappan, S., Barefield, D., Hamm, C., Nef, H., Möllmann, H.:

Sham Surgery and Inter-Individual Heterogeneity Are Major Determinants of Monocyte Subset Kinetics in a Mouse Model of Myocardial Infarction.

PlosOne 2014; 9 (6) e98456.

 

Michalik, K. M., You, X., Manavski, Y., Doddaballapur, A., Zörnig, M., Braun, T., John, D, Ponomareva, Y., Chen, W., Uchida, S., Boon, R. A., Dimmeler, S.:
The long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth.
Circ Res. 2014;114, 1389-1397.

 

Ozturk, N., Singh, N., Mehta, A., Braun, T.  Barreto, G.:
HMGA proteins as modulators of chromatin structure during transcriptional activation.

Frontiers in Cell and Dev. Biol.2014; doi: 10.3389/fcell.2014.00005.

 

Nolte, H., Konzer, A., Ruhs, A., Jungblut, B., Braun, T., Krüger, M.:

Global protein expression profiling of zebrafish organs based on in vivo incorporation of stable isotopes.

J Proteome Res. 2014;13, 2162-2174.

 

Szibor, M., Pöling, J., Warnecke, H., Kubin, T., Braun, T.:

Remodeling and dedifferentiation of adult cardiomyocytes during disease and regeneration.

Cell Mol. Life Sci.2014; 71, 1907-1916

 

Pöling, J., Gajawada, P., Richter, M., Lörchner, H., Polyakova, V., Kostin, S., Shin, J., Boettger, T., Walther, T., Rees, W., Wietelmann, A., Warnecke, H., Kubin, T., Braun, T.:

Therapeutic targeting of the oncostatin M receptor-ß prevents inflammatory heart failure.
Basic Res. Cardiology 2014;109, 396-419.

 

 

2013

Yuan X, Braun T:
An unexpected switch: Regulation of cardiomyocyte proliferation by the homeobox gene meis1.
Circ Res. 2013;113:245-248

Wystub K, Besser J, Bachmann A, Boettger T, Braun T:
Mir-1/133a clusters cooperatively specify the cardiomyogenic lineage by adjustment of myocardin levels during embryonic heart development.
PLoS genetics. 2013;9:e1003793

Uchida S, De Gaspari P, Kostin S, Jenniches K, Kilic A, Izumiya Y, Shiojima I, Grosse Kreymborg K, Renz H, Walsh K, Braun T:
Sca1-derived cells are a source of myocardial renewal in the murine adult heart.
Stem cell reports. 2013;1:397-410

Szibor M, Poling J, Warnecke H, Kubin T, Braun T:

Remodeling and dedifferentiation of adult cardiomyocytes during disease and regeneration.
Cellular and molecular life sciences : CMLS. 2013

Sousounis K, Michel CS, Bruckskotten M, Maki N, Borchardt T, Braun T, Looso M, Tsonis PA:
A microarray analysis of gene expression patterns during early phases of newt lens regeneration.
Molecular vision. 2013;19:135-145

Sousounis K, Looso M, Maki N, Ivester CJ, Braun T, Tsonis PA:
Transcriptome analysis of newt lens regeneration reveals distinct gradients in gene expression patterns.
PloS one. 2013;8:e61445

Schmid T, Gunther S, Mendler L, Braun T:
Loss of nscl-2 in gonadotropin releasing hormone neurons leads to reduction of pro-opiomelanocortin neurons in specific hypothalamic nuclei and causes visceral obesity.

The Journal of neuroscience. 2013;33:10459-10470

Saul VV, de la Vega L, Milanovic M, Kruger M, Braun T, Fritz-Wolf K, Becker K, Schmitz ML:
Hipk2 kinase activity depends on cis-autophosphorylation of its activation loop.

Journal of molecular cell biology. 2013;5:27-38

Ruhs A, Cemic F, Braun T, Kruger M:
Resa(3):A web tool for resampling analysis of arbitrary annotations.
PloS one. 2013;8:e53743

Richter M, Polyakova V, Gajawada P, Poeling J, Warnecke H, Braun T, Walther T, Kubin T:
Oncostatin m induces fgf23 expression in cardiomayocytes.
J Clin Exp Cardiolog. 2013;S9:003.doi:10.4172/2155-9880.S9-003

Pullamsetti SS, Banat GA, Schmall A, Szibor M, Pomagruk D, Hanze J, Kolosionek E, Wilhelm J, Braun T, Grimminger F, Seeger W, Schermuly RT, Savai R:

Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with hif. 

Oncogene. 2013;32:1121-1134

Pohjoismaki JLO, Krueger M, Al-Furoukh N, Lagerstedt A, Karhunen PJ, Braun T:

Postnatal cardiomyocyte growth and mitochondrial reorganization cause multiple changes in the proteome of human cardiomyocytes.
Mol BioSyst. 2013

Pohjoismaki JL, Williams SL, Boettger T, Goffart S, Kim J, Suomalainen A, Moraes CT, Braun T:
Overexpression of twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species.
Proc Natl Acad Sci U S A. 2013;110:19408-19413

Pohjoismaki JL, Kruger M, Al-Furoukh N, Lagerstedt A, Karhunen PJ, Braun T:

Postnatal cardiomyocyte growth and mitochondrial reorganization cause multiple changes in the proteome of human cardiomyocytes.
Mol Biosyst. 2013;9:1210-1219

 

Piatkowski T, Muhlfeld C, Borchardt T, Braun T:
Reconstitution of the myocardium in regenerating newt hearts is preceded by transient deposition of extracellular matrix components.
Stem cells and development. 2013;22:1921-1931

Ohtani K, Zhao C, Dobreva G, Manavski Y, Kluge B, Braun T, Rieger MA, Zeiher AM, Dimmeler S:

Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells.
Circ Res. 2013;113:856-862

Mukhametshina RT, Ruhs A, Singh I, Hasan D, Contreras A, Mehta A, Nikam VS, Ahlbrecht K, Carraro G, Cabrera-Fuentes HA, Jiang D, Voswinckel R, Seeger W, Bellusci S, Scharffetter-Kochanek K, Bagaeva TV, Preissner KT, Boettger T, Braun T, Kruger M, Barreto G:
Quantitative proteome analysis of alveolar type-ii cells reveals a connection of integrin receptor subunits beta 2/6 and wnt signaling.
Journal of proteome research. 2013;12:5598-5608

Looso M, Preussner J, Sousounis K, Bruckskotten M, Michel CS, Lignelli E, Reinhardt R, Hoffner S, Kruger M, Tsonis PA, Borchardt T, Braun T:
A de novo assembly of the newt transcriptome combined with proteomic validation identifies new protein families expressed during tissue regeneration.
Genome biology. 2013;14:R16

Konzer A, Ruhs A, Braun T, Kruger M:

Global protein quantification of mouse heart tissue based on the silac mouse.
Methods in molecular biology. 2013;1005:39-52

Konzer A, Ruhs A, Braun H, Jungblut B, Braun T, Kruger M:
Stable isotope labeling in zebrafish allows in vivo monitoring of cardiac morphogenesis.
Mol Cell Proteomics. 2013;12:1502-1512

Jedrusik-Bode M, Studencka M, Smolka C, Baumann T, Schmidt H, Kampf J, Paap F, Martin S, Tazi J, Muller KM, Kruger M, Braun T, Bober E:
The sirtuin sirt6 regulates stress granule formation in C. elegans and mammals. Journal of cell science. 2013;126:5166-5177

Gunther S, Kim J, Kostin S, Lepper C, Fan CM, Braun T:

Myf5-positive satellite cells contribute to pax7-dependent long-term maintenance of adult muscle stem cells.
Cell Stem Cell. 2013;13:590-601

Good DJ, Braun T:

Nhlh2: At the intersection of obesity and fertility.
Trends in endocrinology and metabolism: TEM. 2013;24:385-390

Gellert P, Ponomareva Y, Braun T, Uchida S:
Noncoder: A web interface for exon array-based detection of long non-coding rnas.

Nucleic Acids Res. 2013;41:e20

Ebelt H, Hillebrand I, Arlt S, Zhang Y, Kostin S, Neuhaus H, Muller-Werdan U, Schwarz E, Werdan K, Braun T:
Treatment with bone morphogenetic protein 2 limits infarct size after myocardial infarction in mice.
Shock. 2013;39:353-360

Danopoulos S, Parsa S, Al Alam D, Tabatabai R, Baptista S, Tiozzo C, Carraro G, Wheeler M, Barreto G, Braun T, Li X, Hajihosseini MK, Bellusci S:
Transient inhibition of fgfr2b-ligands signaling leads to irreversible loss of cellular beta-catenin organization and signaling in aer during mouse limb development.
PloS one. 2013;8:e76248

Al-Furoukh N, Goffart S, Szibor M, Wanrooij S, Braun T:
Binding to g-quadruplex rna activates the mitochondrial gtpase noa1.
Biochimica et biophysica acta. 2013;1833:2933-2942

 

 

2012

Yang J, Bucker S, Jungblut B, Bottger T, Cinnamon Y, Tchorz J, Muller M, Bettler B, Harvey R, Sun QY, Schneider A, Braun T:
Inhibition of notch2 by numb/numblike controls myocardial compaction in the heart.

Cardiovasc Res. 2012;96:276-285

Witzel HR, Jungblut B, Choe CP, Crump JG, Braun T, Dobreva G:
The lim protein ajuba restricts the second heart field progenitor pool by regulating isl1 activity.
Developmental cell. 2012;23:58-70

Taylor J, Rintisch C, Stefanovic S, Pohjoismaki JLO, Blanpain C, Gerhardt H, Adams RH:
Cardiovascular research funding: European molecular biology organization awards.

Circulation. 2012;125:F79-F83

Takefuji M, Wirth A, Lukasova M, Takefuji S, Boettger T, Braun T, Althoff T, Offermanns S, Wettschureck N:
G(13)-mediated signaling pathway is required for pressure overload-induced cardiac remodeling and heart failure.
Circulation. 2012;126:1972-1982

Pullamsetti SS, Banat GA, Schmall A, Szibor M, Pomagruk D, Hanze J, Kolosionek E, Wilhelm J, Braun T, Grimminger F, Seeger W, Schermuly RT, Savai R:

Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with hif.
Oncogene. 2012

Poling J, Gajawada P, Lorchner H, Polyakowa V, Szibor M, Bottger T, Warnecke H, Kubin T, Braun T:
The janus face of osm mediated cardiomyocyte dedifferentiation during cardiac repair and disease.
Cell Cycle. 2012;11

Pohjoismaki JLO, Boettger T, Liu ZP, Goffart S, Szibor M, Braun T:
Oxidative stress during mitochondrial biogenesis compromises mtdna integrity in growing hearts and induces a global DNA repair response.
Nucleic Acids Res. 2012;40:6595-6607

Pohjoismaki JLO:

Letter by Pohjoismaki regarding article, "impaired mitochondrial biogenesis precedes heart failure in right ventricular hypertrophy in congenital heart disease".
Circ-Heart Fail. 2012;5:E15-E15

Maier HJ, Schips TG, Wietelmann A, Kruger M, Brunner C, Sauter M, Klingel K, Bottger T, Braun T, Wirth T: 
Cardiomyocyte-specific ikappab kinase (ikk)/nf-kappab activation induces reversible inflammatory cardiomyopathy and heart failure.
Proc Natl Acad Sci U S A. 2012;109:11794-11799

Looso M, Michel CS, Konzer A, Bruckskotten M, Borchardt T, Kruger M, Braun T:

Spiked-in pulsed in vivo labeling identifies a new member of the ccn family in regenerating newt hearts. 

Journal of proteome research. 2012;11:4693-4704

 

Hergenreider E, Heydt S, Treguer K, Boettger T, Horrevoets AJ, Zeiher AM, Scheffer MP, Frangakis AS, Yin X, Mayr M, Braun T, Urbich C, Boon RA, Dimmeler S: Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs.
Nat Cell Biol. 2012;14:249-256

Groger N, Vitzthum H, Frohlich H, Kruger M, Ehmke H, Braun T, Boettger T:
Targeted mutation of slc4a5 induces arterial hypertension and renal metabolic acidosis.
Hum Mol Genet. 2012;21:1025-1036

Eissmann M, Gutschner T, Hammerle M, Gunther S, Caudron-Herger M, Gross M, Schirmacher P, Rippe K, Braun T, Zornig M, Diederichs S:
Loss of the abundant nuclear non-coding rna malat1 is compatible with life and development.
RNA biology. 2012;9:1076-1087

 

Drexler HC, Ruhs A, Konzer A, Mendler L, Bruckskotten M, Looso M, Gunther S, Boettger T, Kruger M, Braun T:
On marathons and sprints: An integrated quantitative proteomics and transcriptomics analysis of differences between slow and fast muscle fibers.
Mol Cell Proteomics. 2012;11:M111 010801

 

Dobreva G, Braun T:
When silence is broken: Polycomb group proteins in heart development.
Circ Res. 2012;110:372-374

de la Vega L, Grishina I, Moreno R, Kruger M, Braun T, Schmitz ML:

A redox-regulated sumo/acetylation switch of hipk2 controls the survival threshold to oxidative stress.
Molecular cell. 2012;46:472-483

Bruckskotten M, Looso M, Reinhardt R, Braun T, Borchardt T:
Newt-omics: A comprehensive repository for omics data from the newt notophthalmus viridescens.
Nucleic Acids Res. 2012;40:D895-900

Boonsanay V, Kim J, Braun T, Zhou Y:
The emerging role of epigenetic modifiers linking cellular metabolism and gene activity in cardiac progenitor cells.
Trends in cardiovascular medicine. 2012;22:77-81

Boettger T, Braun T:
A new level of complexity: The role of micrornas in cardiovascular development.
Circ Res. 2012;110:1000-1013



2011

Zhou Y, Kim J, Yuan X, Braun T:

Epigenetic modifications of stem cells: A paradigm for the control of cardiac progenitor cells.
Circ Res. 2011;109:1067-1081

Zhang Y, Kohler K, Xu J, Lu D, Braun T, Schlitt A, Buerke M, Muller-Werdan U, Werdan K, Ebert H:
Inhibition of p53 after acute myocardial infarction: Reduction of apoptosis is counteracted by disturbed scar formation and cardiac rupture.
J Mol Cell Cardiol. 2011;50:471-478

Uchida S, Gellert P, Braun T:
Deeply dissecting stemness: Making sense to non-coding rnas in stem cells.
Stem Cell Rev. 2011

Schips TG, Wietelmann A, Hohn K, Schimanski S, Walther P, Braun T, Wirth T, Maier HJ:
Foxo3 induces reversible cardiac atrophy and autophagy in a transgenic mouse model.
Cardiovasc Res. 2011;91:587-597

Poling J, Szibor M, Schimanski S, Ingelmann ME, Rees W, Gajawada P, Kochfar Z, Lorchner H, Salwig I, Shin JY, Wiebe K, Kubin T, Warnecke H, Braun T:
Induction of smooth muscle cell migration during arteriogenesis is mediated by rap2. Arterioscler Thromb Vasc Biol. 2011;31:2297-2305

Pohjoismaki JLO, Goffart S, Spelbrink JN:
Replication stalling by catalytically impaired twinkle induces mitochondrial DNA rearrangements in cultured cells. Mitochondrion. 2011;11:630-634

Pohjoismaki JLO, Goffart S:
Of circles, forks and humanity: Topological organisation and replication of mammalian mitochondrial DNA.
Bioessays. 2011;33:290-299

Nitzki F, Zibat A, Frommhold A, Schneider A, Schulz-Schaeffer W, Braun T, Hahn H:

Uncommitted precursor cells might contribute to increased incidence of embryonal rhabdomyosarcoma in heterozygous patched1-mutant mice.
Oncogene. 2011;30:4428-4436

Kubin T, Poling J, Kostin S, Gajawada P, Hein S, Rees W, Wietelmann A, Tanaka M, Lorchner H, Schimanski S, Szibor M, Warnecke H, Braun T:
Oncostatin m is a major mediator of cardiomyocyte dedifferentiation and remodeling. Cell Stem Cell. 2011;9:420-432

Kossler N, Stricker S, Rodelsperger C, Robinson PN, Kim J, Dietrich C, Osswald M, Kuhnisch J, Stevenson DA, Braun T, Mundlos S, Kolanczyk M:
Neurofibromin (nf1) is required for skeletal muscle development.
Hum Mol Genet. 2011;20:2697-2709

Jordan SD, Kruger M, Willmes DM, Redemann N, Wunderlich FT, Bronneke HS, Merkwirth C, Kashkar H, Olkkonen VM, Bottger T, Braun T, Seibler J, Bruning JC:

Obesity-induced overexpression of mirna-143 inhibits insulin-stimulated akt activation and impairs glucose metabolism.
Nat Cell Biol. 2011;13:434-446

Hoch M, Fischer P, Stapel B, Missol-Kolka E, Sekkali B, Scherr M, Favret F, Braun T, Eder M, Schuster-Gossler K, Gossler A, Hilfiker A, Balligand JL, Drexler H, Hilfiger-Kleiner D:
Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies.
Cell Stem Cell. 2011;9:131-143

 

Heidler J, Al-Furoukh N, Kukat C, Salwig I, Ingelmann ME, Seibel P, Kruger M, Holtz J, Wittig I, Braun T, Szibor M:
Nitric oxide-associated protein 1 (noa1) is necessary for oxygen-dependent regulation of mitochondrial respiratory complexes.
J Biol Chem. 2011;286:32086-32093

Guarani V, Deflorian G, Franco CA, Kruger M, Phng LK, Bentley K, Toussaint L, Dequiedt F, Mostoslavsky R, Schmidt MH, Zimmermann B, Brandes RP, Mione M, Westphal CH, Braun T, Zeiher AM, Gerhardt H, Dimmeler S, Potente M:
Acetylation-dependent regulation of endothelial notch signalling by the sirt1 deacetylase.
Nature. 2011;473:234-238

Groger N, Vitzthum H, Frohlich H, Kruger M, Ehmke H, Braun T, Boettger T:
Targeted mutation of slc4a5 induces arterial hypertension and renal metabolic acidosis.
Hum Mol Genet. 2011

Gellert P, Teranishi M, Jenniches K, De Gaspari P, John D, Grosse Kreymborg K, Braun T, Uchida S:
Gene array analyzer: Alternative usage of gene arrays to study alternative splicing events.
Nucleic Acids Res. 2011

Drexler HC, Ruhs A, Konzer A, Mendler L, Bruckskotten M, Looso M, Gunther S, Boettger T, Kruger M, Braun T:
On marathons and sprints: An integrated quantitative proteomics and transcriptomics analysis of differences between slow and fast muscle fibers.
Mol Cell Proteomics. 2011

Bruckskotten M, Looso M, Reinhardt R, Braun T, Borchardt T:
Newt-omics: A comprehensive repository for omics data from the newt notophthalmus viridescens.
Nucleic Acids Res. 2011;40:D895-900

Braun T, Gautel M:

Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis. 

Nat Rev Mol Cell Biol. 2011;12:349-361

Boeckel JN, Guarani V, Koyanagi M, Roexe T, Lengeling A, Schermuly RT, Gellert P, Braun T, Zeiher A, Dimmeler S:
Jumonji domain-containing protein 6 (jmjd6) is required for angiogenic sprouting and regulates splicing of vegf-receptor 1.
Proc Natl Acad Sci U S A. 2011;108:3276-3281
 


2010
Poeling J, Szibor M, Kubin T, Rees W, Loerchner H, Gajawada P, Warnecke H, Braun T:
The ras-related protein rap2 is part of the fibroblast growth factor-2 initiated arteriogenic program in growing collateral vessels.
Eur Heart J. 2010;31:621-622

Looso M, Borchardt T, Kruger M, Braun T:
Advanced identification of proteins in uncharacterized proteomes by pulsed in vivo stable isotope labeling-based mass spectrometry.
Mol Cell Proteomics. 2010;9:1157-1166

Liu ZP, Yue SJ, Chen XB, Kubin T, Braun T:
Regulation of cardiomyocyte polyploidy and multinucleation by cycling1.
Circ Res. 2010;106:1498-U1110

Kreymborg KG, Uchida S, Gellert P, Schneider A, Boettger T, Voswinckel R, Wietelmann A, Szibor M, Weissmann N, Ghofrani AH, Schermuly R, Schranz D, Seeger W, Braun T:
Identification of right heart-enriched genes in a murine model of chronic outflow tract obstruction.
J Mol Cell Cardiol. 2010;49:598-605

Kreymborg K, Uchida S, Gellert P, Schneider A, Boettger T, Voswinckel R, Wietelmann A, Szibor M, Weissmann N, Ghofrani AH, Schermuly R, Schranz D, Seeger W, Braun T:
Identification of right heart-enriched genes in a murine model of chronic outflow tract obstruction.
J Mol Cell Cardiol. 2010;49:598-605

Groger N, Frohlich H, Maier H, Olbrich A, Kostin S, Braun T, Boettger T:
Slc4a11 prevents osmotic imbalance leading to corneal endothelial dystrophy, deafness, and polyuria.
J Biol Chem. 2010;285:14467-14474

Gellert P, Jenniches K, Braun T, Uchida S:
C-it: A knowledge database for tissue-enriched genes.
Bioinformatics. 2010;26:2328-2333

Dobreva G, Braun T:
The yin and yang of polycomb repression in regenerating muscle.
Cell Stem Cell. 2010;7:422-424

Bruckskotten M, Looso M, Cemic F, Konzer A, Hemberger J, Kruger M, Braun T:

Pca2go: A new multivariate statistics based method to identify highly expressed go-terms.
Bmc Bioinformatics. 2010;11

Borchardt T, Looso M, Bruckskotten M, Weis P, Kruse J, Braun T:
Analysis of newly established est databases reveals similarities between heart regeneration in newt and fish.
Bmc Genomics. 2010;11
 


2009


Uchida S, Schneider A, Wiesnet M, Jungblut B, Zarjitskaya P, Jenniches K, Kreymborg KG, Seeger W, Braun T:

An integrated approach for the systematic identification and characterization of heart-enriched genes with unknown functions.
Bmc Genomics. 2009;10:100

Tuder RM, Abman SH, Braun T, Capron F, Stevens T, Thistlethwaite PA, Haworth SG:

Development and pathology of pulmonary hypertension.
Journal of the American College of Cardiology. 2009;54:S3-9

Ruschke K, Ebelt H, Kloting N, Boettger T, Raum K, Bluher M, Braun T:
Defective peripheral nerve development is linked to abnormal architecture and metabolic activity of adipose tissue in nscl-2 mutant mice.
PloS one. 2009;4:e5516

Mielcarek M, Piotrowska I, Schneider A, Gunther S, Braun T:
Vito-2, a new sid domain protein, is expressed in the myogenic lineage during early mouse embryonic development.
Gene expression patterns : GEP. 2009;9:129-137


Loch T, Vakhrusheva O, Piotrowska I, Ziolkowski W, Ebelt H, Braun T, Bober E:

Different extent of cardiac malfunction and resistance to oxidative stress in heterozygous and homozygous manganese-dependent superoxide dismutase-mutant mice.
Cardiovasc Res. 2009;82:448-457

Liu Z, Shen J, Pu K, Katus HA, Ploger F, Tiefenbacher CP, Chen X, Braun T:
Gdf5 and bmp2 inhibit apoptosis via activation of bmpr2 and subsequent stabilization of xiap.
Biochimica et biophysica acta. 2009;1793:1819-1827

Gellert P, Uchida S, Braun T:
Exon array analyzer: A web interface for affymetrix exon array analysis. Bioinformatics. 2009;25:3323-3324

Braun T, Preissner KT:
Cutting edge research for novel therapies of heart and lung diseases.
Thrombosis and haemostasis. 2009;101:610-612

Braun T, Dimmeler S:
Breaking the silence: Stimulating proliferation of adult cardiomyocytes. Developmental cell. 2009;17:151-153

Boettger T, Beetz N, Kostin S, Schneider J, Kruger M, Hein L, Braun T:
Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the mir143/145 gene cluster.
The Journal of clinical investigation. 2009;119:2634-2647

Barbosa-Sicard E, Fromel T, Keseru B, Brandes RP, Morisseau C, Hammock BD, Braun T, Kruger M, Fleming I:
Inhibition of the soluble epoxide hydrolase by tyrosine nitration.
J Biol Chem. 2009;284:28156-28163

 


2008
Ziebart T, Yoon CH, Trepels T, Wietelmann A, Braun T, Kiessling F, Stein S, Grez M, Ihling C, Muhly-Reinholz M, Carmona G, Urbich C, Zeiher AM, Dimmeler S:
Sustained persistence of transplanted proangiogenic cells contributes to neovascularization and cardiac function after ischemia.
Circ Res. 2008;103:1327-1334

Vakhrusheva O, Smolka C, Gajawada P, Kostin S, Boettger T, Kubin T, Braun T, Bober E:
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice.
Circ Res. 2008;102:703-710

Vakhrusheva O, Braeuer D, Liu Z, Braun T, Bober E: 
Sirt7-dependent inhibition of cell growth and proliferation might be instrumental to mediate tissue integrity during aging.

Journal of physiology and pharmacology. 2008;59 Suppl 9:201-212

Sweetman D, Goljanek K, Rathjen T, Oustanina S, Braun T, Dalmay T, Munsterberg A:
Specific requirements of mrfs for the expression of muscle specific micrornas, mir-1, mir-206 and mir-133.
Developmental biology. 2008;321:491-499

Gensch N, Borchardt T, Schneider A, Riethmacher D, Braun T:
Different autonomous myogenic cell populations revealed by ablation of myf5-expressing cells during mouse embryogenesis.
Development. 2008;135:1597-1604

Frank H, Groger N, Diener M, Becker C, Braun T, Boettger T:
Lactaturia and loss of sodium-dependent lactate uptake in the colon of slc5a8-deficient mice.
J Biol Chem. 2008;283:24729-24737

Ebelt H, Zhang Y, Kohler K, Xu J, Gajawada P, Boettger T, Hollemann T, Muller-Werdan U, Werdan K, Braun T:

Directed expression of dominant-negative p73 enables proliferation of cardiomyocytes in mice. 

J Mol Cell Cardiol. 2008;45:411-419

Ebelt H, Zhang Y, Kampke A, Xu J, Schlitt A, Buerke M, Muller-Werdan U, Werdan K, Braun T:
E2f2 expression induces proliferation of terminally differentiated cardiomyocytes in vivo.
Cardiovasc Res. 2008;80:219-226

Belema-Bedada F, Uchida S, Martire A, Kostin S, Braun T:
Efficient homing of multipotent adult mesenchymal stem cells depends on frount-mediated clustering of ccr2.
Cell Stem Cell. 2008;2:566-575

Bedada FB, Braun T:
Partial induction of the myogenic program in noncommitted adult stem cells. Cells, tissues, organs. 2008;188:189-201

 

 

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