AG Böttger

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Function of non-coding RNAs in the cardiovascular system

Scientific focus

The progress in annotation of the mammalian genome has identified non-coding RNAs (ncRNAs) to be an important class of molecules. The research of our group focuses on a subclass of ncRNAs, the miRNA molecules, and we are specifically interested to understand the molecular functions of miRNAs in the cardiovascular system (see Boettger et al., 2009, Boettger & Braun 2012, Wystub et al., 2013, Schweisgut et al., 2017 and Wüst et al., 2018) Some of our findings regarding the miRNA function in the cardiovascular system are summarized below.

In addition to analysis of small non-coding RNAs we currently expand our work to molecular functions of other classes of non-coding RNAs in the cardiovascular system and skeletal muscle.


Ion transporters have essential functions in all biological processes. To understand the role of ion transporters in physiology and human disease we analyzed knock-out mouse models for specific transporters with functions in kidney, inner ear and eye (see Frank et al., 2008, Groeger et al., 2010 or Groeger et al, 2011).


Group members

Alix Kleine-Birkenheuer,Ina Klockner, Christian Schutt,Sylvia Thomas, Melissa Valussi,Maria Weiß


Applications for Master- and PhD-student positions are welcome.


Priv.-Doz. Dr. rer. nat. Thomas Böttger

Abt. I - Entwicklung und Umbau des Herzens

Max-Planck-Institut für Herz- und Lungenforschung

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61231 Bad Nauheim

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