Postdoctoral positions (m/f/d) | Circadian regulation of Cardiometabolism

Max Planck Institute for Heart and Lung Research - W. G. Kerckhoff Institute, Bad Nauheim

Type of Job

Scientist

Developmental and Evolutionary Biology & Genetics Immunobiology and Infection Biology & Medicine Physiology

Job Code: Ref. 2022_29

Job offer from December 09, 2022

Postdoctoral positions (m/f/d) are available in the Dierickx lab (Independent Research Group)  on Circadian regulation of Cardiometabolism at the Max Planck Institute for Heart and Lung Research in Bad Nauheim, Germany.

The Dierickx lab is interested in how the circadian clock drives rhythmic processes in the heart. We make use of in vivo as well as in vitro systems to investigate how (disruption of) the clock contributes to normal cardiac functioning but also pathophysiology. We are looking for a Postdoc who is excited about circadian rhythms and interested in our recent findings:

  1. the circadian clock starts ticking (as indicated by rhythmic Per2::luciferase signal and circadian RNA-seq) during human embryonic stem cell-directed cardiomyocyte differentiation, which drives a rhythmic response to stress in vitro.
  2. clock protein (REV-ERB) disruption in cardiomyocytes leads to metabolic imbalance, dilated cardiomyopathy and premature death in mice.

For more detailed information, please see our recent publications: (Dierickx et al., EMBO Reports, 2017; Dierickx et al., EMBO Reports, 2018; Dierickx et al, PNAS, 2019; Dierickx et al., Nature Cardiovascular Research, 2021; Dierickx et al., Frontiers in Molecular medicine, 2022, Carpenter & Dierickx, Am. J. Phys-Cell. Phys, 2022).

For the in vitro project, previous experience with (human pluripotent) stem cell culture and 2D/3D cardiac models is a great plus. Different types of real-time tracking will be used to get an in depth understanding of clock development and deregulation in disease. We are excited to announce that a multiple-purpose automated high-throughput (fluorescence/bioluminescence) microscope will aid to develop this project.

For the in vivo project, previous experience with (cardiac) animal models and whole-body physiology are a great plus. Different genetically engineered models of multiple clock proteins combined with next-generation sequencing techniques will be deployed to tackle the mechanism by which clock protein disruption leads to metabolic defects.

The Max Planck Society strives for gender and diversity equality; we welcome applications from all backgrounds. Furthermore, the Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.

How to apply

Applications should include a cover letter and a list of 3 potential references and should send via our application portal by Jan. 31, 2023.

Inquiries are welcome and could be sent to .

Go to Editor View